DR --Biomarker Pathway List

841 biomarker pathways

Pathway ID	Term Description	Observed Gene Count	Background Gene Count	Strength	Biomarkers
GO:0005576	extracellular region	56	4166	0.59	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,PLA2G7,LCN9,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,AKR1B10,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TXN,THBD,EDN1,AVP,C1QTNF3,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,ENO2,FGF21,VEGFA,C19orf80
GO:0005615	extracellular space	50	3195	0.66	CEACAM6,TGFB1,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,KLKB1,ICAM1,SEMA3A,PLA2G7,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,MBL2,DKK1,TXN,THBD,EDN1,AVP,C1QTNF3,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,ENO2,FGF21,VEGFA
GO:0031982	vesicle	38	3879	0.46	CEACAM6,TGFB1,HGF,MPO,APOE,CHI3L1,FABP4,SORL1,LRP6,KLKB1,ICAM1,PML,WNT3A,ACE,ALB,PTX3,LRG1,IGF1,MMP14,HBA1,APOA2,NGF,ANGPTL3,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SOD3,SPP1,INS,ITGB2,MUC16,TNF,GPI,ENO2,VEGFA
GO:0031012	extracellular matrix	15	527	0.92	TGFB1,APOE,CHI3L1,ICAM1,PTX3,TNFRSF11B,ANGPTL4,MMP14,CTGF,ANGPTL3,MBL2,SOD3,LAMA1,ADIPOQ,VEGFA
GO:0031410	cytoplasmic vesicle	29	2386	0.55	CEACAM6,TGFB1,HGF,MPO,APOE,CHI3L1,SORL1,LRP6,PML,WNT3A,ACE,ALB,PTX3,LRG1,IGF1,MMP14,HBA1,APOA2,NGF,ANGPTL3,DKK1,TLR4,EDN1,AVP,INS,ITGB2,TNF,GPI,VEGFA
GO:0009986	cell surface	17	824	0.78	CEACAM6,TGFB1,SORL1,LRP6,ICAM1,WNT3A,ACE,IL6R,CD40LG,ANGPTL3,MBL2,TLR4,THBD,ITGB2,ADIPOQ,TNF,VEGFA
GO:0034774	secretory granule lumen	11	324	1	TGFB1,HGF,MPO,CHI3L1,ALB,PTX3,LRG1,IGF1,INS,GPI,VEGFA
GO:0012505	endomembrane system	36	4542	0.36	CEACAM6,TGFB1,HGF,MPO,APOE,CHI3L1,SORL1,LRP6,PML,WNT3A,ACE,ALB,PTX3,LRG1,IGF1,MMP14,NAGPA,CYP2D6,CTGF,APOA2,NGF,ANGPTL3,FNDC5,DKK1,TLR4,EDN1,AVP,SOD3,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,VEGFA
GO:0005796	Golgi lumen	7	101	1.31	TGFB1,WNT3A,MMP14,NGF,SOD3,INS,MUC16
GO:0030141	secretory granule	15	845	0.71	CEACAM6,TGFB1,HGF,MPO,CHI3L1,ALB,PTX3,LRG1,IGF1,EDN1,AVP,INS,ITGB2,GPI,VEGFA
GO:0099503	secretory vesicle	16	1010	0.67	CEACAM6,TGFB1,HGF,MPO,CHI3L1,ALB,PTX3,LRG1,IGF1,NGF,EDN1,AVP,INS,ITGB2,GPI,VEGFA
GO:0072562	blood microparticle	6	115	1.18	TGFB1,APOE,ALB,ANGPTL4,HBA1,APOA2
GO:0005768	endosome	14	959	0.63	APOE,SORL1,LRP6,PML,WNT3A,ACE,MMP14,APOA2,NGF,ANGPTL3,DKK1,TLR4,INS,TNF
GO:0070062	extracellular exosome	21	2099	0.47	MPO,APOE,CHI3L1,FABP4,SORL1,KLKB1,ICAM1,WNT3A,ACE,ALB,LRG1,HBA1,APOA2,TXN,C1QTNF3,SOD3,SPP1,ITGB2,MUC16,GPI,ENO2
GO:0031093	platelet alpha granule lumen	5	68	1.33	TGFB1,HGF,ALB,IGF1,VEGFA
GO:0005769	early endosome	9	375	0.85	APOE,SORL1,LRP6,PML,WNT3A,APOA2,ANGPTL3,DKK1,TLR4
GO:0062023	collagen-containing extracellular matrix	9	396	0.82	TGFB1,APOE,ICAM1,ANGPTL4,ANGPTL3,MBL2,SOD3,LAMA1,ADIPOQ
GO:0009897	external side of plasma membrane	8	331	0.85	ICAM1,ACE,IL6R,CD40LG,TLR4,THBD,ITGB2,TNF
GO:0071682	endocytic vesicle lumen	3	20	1.64	MPO,APOE,HBA1
GO:0005788	endoplasmic reticulum lumen	7	308	0.82	APOE,WNT3A,ALB,APOA2,EDN1,SPP1,INS
GO:0034364	high-density lipoprotein particle	3	29	1.48	APOE,PLA2G7,APOA2
GO:1990851	Wnt-Frizzled-LRP5/6 complex	2	4	2.16	LRP6,WNT3A
GO:0005794	Golgi apparatus	15	1584	0.44	TGFB1,APOE,SORL1,WNT3A,ALB,MMP14,NAGPA,CTGF,NGF,ANGPTL3,TLR4,SOD3,SPP1,INS,MUC16
GO:0031901	early endosome membrane	5	162	0.95	SORL1,LRP6,PML,WNT3A,DKK1
GO:0005783	endoplasmic reticulum	14	1438	0.45	APOE,CHI3L1,SORL1,LRP6,PML,WNT3A,ALB,CYP2D6,APOA2,FNDC5,EDN1,SPP1,INS,ADIPOQ
GO:0005102	signaling receptor binding	38	1581	0.85	TGFB1,HGF,CCL2,APOE,CRP,FABP4,LRP6,ICAM1,SEMA3A,WNT3A,ACE,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,APOA2,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,EDN1,AVP,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0048018	receptor ligand activity	24	490	1.16	TGFB1,HGF,CCL2,SEMA3A,WNT3A,TNFRSF11B,IGF1,CXCL8,CTGF,NGF,CD40LG,ANGPTL3,FNDC5,DKK1,EDN1,AVP,SPP1,INS,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0005125	cytokine activity	12	233	1.18	TGFB1,CCL2,WNT3A,TNFRSF11B,CXCL8,CD40LG,EDN1,SPP1,ADIPOQ,TNF,GPI,VEGFA
GO:0008083	growth factor activity	10	161	1.26	TGFB1,HGF,IGF1,CTGF,NGF,ANGPTL3,DKK1,GPI,FGF21,VEGFA
GO:0005515	protein binding	48	7026	0.3	CEACAM6,TGFB1,EPOR,HGF,CCL2,APOE,CRP,FABP4,SORL1,LRP6,DESI1,ICAM1,SEMA3A,PML,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0005178	integrin binding	8	147	1.2	ICAM1,IGF1,MMP14,CTGF,CD40LG,ANGPTL3,SPP1,ITGB2
GO:0098772	molecular function regulator	30	3422	0.41	TGFB1,HGF,CCL2,APOE,LRP6,SEMA3A,PML,WNT3A,TNFRSF11B,ANGPTL4,IGF1,CXCL8,CTGF,APOA2,NGF,CD40LG,ANGPTL3,FNDC5,DKK1,EDN1,AVP,SPP1,INS,ADIPOQ,TNF,GPI,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0005179	hormone activity	7	124	1.22	IGF1,FNDC5,EDN1,AVP,INS,ADIPOQ,C19orf80
GO:0042802	identical protein binding	21	1896	0.51	CEACAM6,TGFB1,EPOR,HGF,APOE,CRP,LRP6,DESI1,PML,ALB,PTX3,ANGPTL4,APOA2,IL6R,TLR4,TXN,C1QTNF3,INS,ADIPOQ,TNF,VEGFA
GO:0005488	binding	60	12516	0.15	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,ICAM1,SEMA3A,PML,PLA2G7,LCN9,WNT3A,ACE,ALB,PTX3,TNFRSF11B,NGB,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,CYP2D6,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SOD3,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,ENO2,FGF21,VEGFA,C19orf80
GO:0005126	cytokine receptor binding	8	264	0.95	TGFB1,CCL2,LRG1,CXCL8,NGF,CD40LG,TNF,VEGFA
GO:0070325	lipoprotein particle receptor binding	4	27	1.64	APOE,CRP,APOA2,DKK1
GO:0071813	lipoprotein particle binding	4	29	1.61	APOE,CRP,SORL1,APOA2
GO:0016209	antioxidant activity	5	74	1.3	MPO,APOE,ALB,TXN,SOD3
GO:0044877	protein-containing complex binding	15	1216	0.56	HGF,APOE,CRP,SORL1,ICAM1,PTX3,IGF1,MMP14,CTGF,APOA2,CD40LG,ANGPTL3,SPP1,INS,ITGB2
GO:0001846	opsonin binding	3	15	1.77	CRP,PTX3,ITGB2
GO:0008201	heparin binding	6	172	1.01	MPO,APOE,CTGF,ANGPTL3,SOD3,VEGFA
GO:0001664	G protein-coupled receptor binding	7	294	0.84	CCL2,LRP6,WNT3A,ACE,CXCL8,EDN1,AVP
GO:0001848	complement binding	3	21	1.62	CRP,PTX3,ITGB2
GO:0050750	low-density lipoprotein particle receptor binding	3	22	1.6	APOE,CRP,DKK1
GO:0001540	amyloid-beta binding	4	76	1.19	APOE,SORL1,TLR4,ITGB2
GO:0038191	neuropilin binding	2	5	2.07	SEMA3A,VEGFA
hsa05144	Malaria	9	46	1.76	TGFB1,HGF,CCL2,ICAM1,CXCL8,CD40LG,TLR4,ITGB2,TNF
hsa05323	Rheumatoid arthritis	8	85	1.44	TGFB1,CCL2,ICAM1,CXCL8,TLR4,ITGB2,TNF,VEGFA
hsa04933	AGE-RAGE signaling pathway in diabetic complications	8	98	1.38	TGFB1,CCL2,ICAM1,CXCL8,THBD,EDN1,TNF,VEGFA
hsa04979	Cholesterol metabolism	6	48	1.56	APOE,ENSG00000224916,ANGPTL4,APOA2,ANGPTL3,C19orf80
hsa05200	Pathways in cancer	13	517	0.87	TGFB1,EPOR,HGF,LRP6,PML,WNT3A,IGF1,CXCL8,IL6R,EDN1,LAMA1,FGF21,VEGFA
hsa04151	PI3K-Akt signaling pathway	11	350	0.96	EPOR,HGF,IGF1,IL6R,NGF,TLR4,LAMA1,SPP1,INS,FGF21,VEGFA
hsa04066	HIF-1 signaling pathway	7	106	1.29	IGF1,IL6R,TLR4,EDN1,INS,ENO2,VEGFA
hsa05418	Fluid shear stress and atherosclerosis	7	130	1.2	CCL2,ICAM1,TXN,THBD,EDN1,TNF,VEGFA
hsa04060	Cytokine-cytokine receptor interaction	9	282	0.97	TGFB1,EPOR,CCL2,TNFRSF11B,CXCL8,IL6R,NGF,CD40LG,TNF
hsa05410	Hypertrophic cardiomyopathy	6	89	1.29	TGFB1,ACE,IGF1,EDN1,LAMA1,TNF
hsa05142	Chagas disease	6	99	1.25	TGFB1,CCL2,ACE,CXCL8,TLR4,TNF
hsa05146	Amoebiasis	6	100	1.24	TGFB1,CXCL8,TLR4,LAMA1,ITGB2,TNF
hsa05205	Proteoglycans in cancer	7	196	1.02	TGFB1,HGF,WNT3A,IGF1,TLR4,TNF,VEGFA
hsa03320	PPAR signaling pathway	5	75	1.29	FABP4,UCP1,ANGPTL4,APOA2,ADIPOQ
hsa04010	MAPK signaling pathway	8	288	0.91	TGFB1,HGF,IGF1,NGF,INS,TNF,FGF21,VEGFA
hsa04015	Rap1 signaling pathway	7	202	1.01	HGF,IGF1,NGF,INS,ITGB2,FGF21,VEGFA
hsa04932	Non-alcoholic fatty liver disease	6	148	1.07	TGFB1,CXCL8,IL6R,INS,ADIPOQ,TNF
hsa05164	Influenza A	6	165	1.03	CCL2,ICAM1,PML,CXCL8,TLR4,TNF
hsa04064	NF-kappa B signaling pathway	5	101	1.16	ICAM1,CXCL8,CD40LG,TLR4,TNF
hsa05145	Toxoplasmosis	5	105	1.14	TGFB1,CD40LG,TLR4,LAMA1,TNF
hsa04668	TNF signaling pathway	5	112	1.12	CCL2,ICAM1,MMP14,EDN1,TNF
hsa05134	Legionellosis	4	55	1.33	CXCL8,TLR4,ITGB2,TNF
hsa05416	Viral myocarditis	4	55	1.33	ICAM1,CD40LG,LAMA1,ITGB2
hsa05140	Leishmaniasis	4	70	1.22	TGFB1,TLR4,ITGB2,TNF
hsa04014	Ras signaling pathway	6	226	0.89	HGF,IGF1,NGF,INS,FGF21,VEGFA
hsa05133	Pertussis	4	74	1.2	CXCL8,TLR4,ITGB2,TNF
hsa05226	Gastric cancer	5	144	1.01	TGFB1,HGF,LRP6,WNT3A,FGF21
hsa01521	EGFR tyrosine kinase inhibitor resistance	4	78	1.18	HGF,IGF1,IL6R,VEGFA
hsa04150	mTOR signaling pathway	5	151	0.99	LRP6,WNT3A,IGF1,INS,TNF
hsa04610	Complement and coagulation cascades	4	82	1.15	KLKB1,MBL2,THBD,ITGB2
hsa04061	Viral protein interaction with cytokine and cytokine receptor	4	96	1.09	CCL2,CXCL8,IL6R,TNF
hsa04621	NOD-like receptor signaling pathway	5	174	0.92	CCL2,CXCL8,TLR4,TXN,TNF
hsa05414	Dilated cardiomyopathy	4	95	1.09	TGFB1,IGF1,LAMA1,TNF
hsa04620	Toll-like receptor signaling pathway	4	101	1.06	CXCL8,TLR4,SPP1,TNF
hsa04510	Focal adhesion	5	198	0.87	HGF,IGF1,LAMA1,SPP1,VEGFA
hsa04930	Type II diabetes mellitus	3	46	1.28	INS,ADIPOQ,TNF
hsa05135	Yersinia infection	4	125	0.97	CCL2,CXCL8,TLR4,TNF
hsa05163	Human cytomegalovirus infection	5	218	0.83	CCL2,CXCL8,IL6R,TNF,VEGFA
hsa05321	Inflammatory bowel disease	3	60	1.16	TGFB1,TLR4,TNF
hsa05010	Alzheimer disease	6	355	0.69	APOE,LRP6,WNT3A,DKK1,INS,TNF
hsa04145	Phagosome	4	142	0.92	MPO,MBL2,TLR4,ITGB2
hsa05211	Renal cell carcinoma	3	66	1.12	TGFB1,HGF,VEGFA
hsa05224	Breast cancer	4	145	0.91	LRP6,WNT3A,IGF1,FGF21
hsa04390	Hippo signaling pathway	4	153	0.88	TGFB1,WNT3A,CTGF,ITGB2
hsa05218	Melanoma	3	72	1.09	HGF,IGF1,FGF21
hsa05161	Hepatitis B	4	159	0.87	TGFB1,CXCL8,TLR4,TNF
hsa05225	Hepatocellular carcinoma	4	160	0.86	TGFB1,HGF,LRP6,WNT3A
hsa05152	Tuberculosis	4	168	0.84	TGFB1,TLR4,ITGB2,TNF
hsa05202	Transcriptional misregulation in cancer	4	171	0.83	MPO,PML,IGF1,CXCL8
hsa05150	Staphylococcus aureus infection	3	86	1.01	ICAM1,MBL2,ITGB2
hsa04211	Longevity regulating pathway	3	87	1	IGF1,INS,ADIPOQ
hsa04640	Hematopoietic cell lineage	3	91	0.98	EPOR,IL6R,TNF
hsa04657	IL-17 signaling pathway	3	92	0.98	CCL2,CXCL8,TNF
hsa05310	Asthma	2	27	1.34	CD40LG,TNF
hsa05165	Human papillomavirus infection	5	325	0.65	WNT3A,LAMA1,SPP1,TNF,VEGFA
hsa05132	Salmonella infection	4	209	0.75	CXCL8,TLR4,TXN,TNF
hsa05166	Human T-cell leukemia virus 1 infection	4	211	0.74	TGFB1,ICAM1,ITGB2,TNF
GO:0051240	positive regulation of multicellular organismal process	37	1770	0.79	TGFB1,HGF,APOE,CHI3L1,FABP4,MTNR1B,SORL1,UCP1,ICAM1,SEMA3A,PML,WNT3A,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA
GO:0051239	regulation of multicellular organismal process	43	3227	0.59	TGFB1,HGF,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,THBD,EDN1,AVP,C1QTNF3,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA
GO:0032879	regulation of localization	38	2740	0.61	CEACAM6,TGFB1,HGF,CCL2,APOE,CRP,MTNR1B,SORL1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,PTX3,IGF1,CXCL8,MMP14,APOA2,IL6R,CD40LG,ANGPTL3,MBL2,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA
GO:0048584	positive regulation of response to stimulus	35	2257	0.66	TGFB1,EPOR,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,LRG1,IGF1,CXCL8,CTGF,IL6R,NGF,CD40LG,MBL2,DKK1,TLR4,TXN,THBD,EDN1,INS,ITGB2,MUC16,ADIPOQ,TNF,FGF21,VEGFA
GO:0001932	regulation of protein phosphorylation	29	1459	0.76	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0048518	positive regulation of biological process	53	6112	0.4	CEACAM6,TGFB1,EPOR,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,PTX3,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0060548	negative regulation of cell death	25	999	0.86	CEACAM6,HGF,MPO,CCL2,APOE,MTNR1B,SORL1,LRP6,ICAM1,WNT3A,ALB,ANGPTL4,IGF1,CTGF,NGF,CD40LG,DKK1,TXN,EDN1,AVP,INS,TNF,TNFAIP8,FGF21,VEGFA
GO:0010941	regulation of cell death	30	1696	0.71	CEACAM6,HGF,MPO,CCL2,APOE,MTNR1B,SORL1,LRP6,ICAM1,PML,WNT3A,ALB,ANGPTL4,IGF1,HBA1,CTGF,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA
GO:0001934	positive regulation of protein phosphorylation	24	1019	0.84	TGFB1,HGF,CCL2,APOE,CHI3L1,ICAM1,SEMA3A,WNT3A,ACE,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0065008	regulation of biological quality	43	4042	0.49	TGFB1,MPO,CCL2,APOE,CRP,FABP4,MTNR1B,SORL1,LRP6,UCP1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,ALB,TNFRSF11B,ANGPTL4,IGF1,AKR1B10,CYP2D6,CTGF,APOA2,NGF,CD40LG,ANGPTL3,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0043410	positive regulation of MAPK cascade	19	543	1.01	TGFB1,HGF,CCL2,APOE,CHI3L1,ICAM1,SEMA3A,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,EDN1,INS,TNF,FGF21,VEGFA
GO:0043408	regulation of MAPK cascade	21	725	0.93	TGFB1,HGF,CCL2,APOE,CHI3L1,SORL1,ICAM1,SEMA3A,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,EDN1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0030334	regulation of cell migration	22	865	0.87	CEACAM6,TGFB1,HGF,CCL2,APOE,SORL1,ICAM1,SEMA3A,PLA2G7,ACE,IGF1,CXCL8,MMP14,IL6R,ANGPTL3,EDN1,LAMA1,INS,ADIPOQ,TNF,GPI,VEGFA
GO:0040012	regulation of locomotion	23	969	0.84	CEACAM6,TGFB1,HGF,CCL2,APOE,SORL1,ICAM1,SEMA3A,PLA2G7,WNT3A,ACE,IGF1,CXCL8,MMP14,IL6R,ANGPTL3,EDN1,LAMA1,INS,ADIPOQ,TNF,GPI,VEGFA
GO:0051247	positive regulation of protein metabolic process	29	1715	0.69	TGFB1,HGF,CCL2,APOE,CHI3L1,SORL1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ADIPOQ,TNF,FGF21,VEGFA,C19orf80
GO:0032270	positive regulation of cellular protein metabolic process	28	1635	0.7	TGFB1,HGF,CCL2,APOE,CHI3L1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ADIPOQ,TNF,FGF21,VEGFA,C19orf80
GO:0050790	regulation of catalytic activity	33	2386	0.61	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,LRP6,ICAM1,PML,WNT3A,ACE,PTX3,ANGPTL4,IGF1,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,TXN,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,VEGFA,C19orf80
GO:0050896	response to stimulus	57	8046	0.32	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ALB,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,AKR1B10,CYP2D6,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0051270	regulation of cellular component movement	23	1009	0.82	CEACAM6,TGFB1,HGF,CCL2,APOE,SORL1,ICAM1,SEMA3A,PLA2G7,WNT3A,ACE,IGF1,CXCL8,MMP14,IL6R,ANGPTL3,EDN1,LAMA1,INS,ADIPOQ,TNF,GPI,VEGFA
GO:0031401	positive regulation of protein modification process	25	1252	0.77	TGFB1,HGF,CCL2,APOE,CHI3L1,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0042221	response to chemical	43	4333	0.46	TGFB1,EPOR,HGF,MPO,CCL2,APOE,CHI3L1,FABP4,LRP6,UCP1,ICAM1,SEMA3A,PML,WNT3A,ALB,TNFRSF11B,IGF1,CXCL8,MMP14,HBA1,AKR1B10,CYP2D6,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,TXN,THBD,EDN1,AVP,SOD3,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0048583	regulation of response to stimulus	42	4114	0.47	TGFB1,EPOR,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,LRG1,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,FGF21,VEGFA
GO:0045859	regulation of protein kinase activity	21	812	0.88	TGFB1,HGF,APOE,CHI3L1,FABP4,SORL1,LRP6,WNT3A,ACE,IGF1,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ADIPOQ,TNF,VEGFA
GO:0010647	positive regulation of cell communication	29	1823	0.67	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,ICAM1,SEMA3A,PML,WNT3A,LRG1,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,C1QTNF3,SPP1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0023056	positive regulation of signaling	29	1831	0.67	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,ICAM1,SEMA3A,PML,WNT3A,LRG1,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,C1QTNF3,SPP1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0048522	positive regulation of cellular process	48	5579	0.4	CEACAM6,TGFB1,EPOR,HGF,CCL2,APOE,CRP,CHI3L1,MTNR1B,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,PTX3,LRG1,IGF1,CXCL8,MMP14,HBA1,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0009605	response to external stimulus	32	2310	0.61	TGFB1,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,UCP1,ICAM1,SEMA3A,PML,WNT3A,ALB,PTX3,TNFRSF11B,LRG1,CXCL8,MMP14,IL6R,MBL2,TLR4,THBD,EDN1,LAMA1,SPP1,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0051246	regulation of protein metabolic process	35	2828	0.56	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,LRP6,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0032268	regulation of cellular protein metabolic process	34	2693	0.57	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,LRP6,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0070887	cellular response to chemical stimulus	35	2919	0.54	TGFB1,EPOR,HGF,MPO,CCL2,APOE,CHI3L1,FABP4,LRP6,UCP1,ICAM1,PML,WNT3A,ALB,TNFRSF11B,IGF1,CXCL8,HBA1,AKR1B10,CYP2D6,CTGF,IL6R,NGF,CD40LG,TLR4,TXN,EDN1,SOD3,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0043066	negative regulation of apoptotic process	21	893	0.84	CEACAM6,HGF,MPO,CCL2,APOE,MTNR1B,LRP6,ICAM1,ALB,ANGPTL4,IGF1,NGF,CD40LG,DKK1,EDN1,AVP,INS,TNF,TNFAIP8,FGF21,VEGFA
GO:0006954	inflammatory response	17	515	0.98	TGFB1,CCL2,CRP,CHI3L1,KLKB1,ICAM1,PTX3,CXCL8,APOA2,IL6R,CD40LG,MBL2,TLR4,SPP1,INS,ITGB2,TNF
GO:0032101	regulation of response to external stimulus	22	1013	0.8	TGFB1,HGF,CCL2,APOE,FABP4,KLKB1,SEMA3A,PML,PLA2G7,WNT3A,CXCL8,IL6R,TLR4,THBD,EDN1,C1QTNF3,SPP1,INS,MUC16,ADIPOQ,TNF,VEGFA
GO:0051094	positive regulation of developmental process	25	1389	0.72	TGFB1,HGF,APOE,CHI3L1,SORL1,SEMA3A,PML,WNT3A,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,IL6R,NGF,ANGPTL3,FNDC5,DKK1,EDN1,INS,ITGB2,ADIPOQ,TNF,VEGFA
GO:0051050	positive regulation of transport	21	923	0.82	TGFB1,CCL2,APOE,SORL1,WNT3A,PTX3,IGF1,APOA2,MBL2,TLR4,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA
GO:0051338	regulation of transferase activity	22	1036	0.79	TGFB1,HGF,APOE,CHI3L1,FABP4,SORL1,LRP6,PML,WNT3A,ACE,IGF1,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ADIPOQ,TNF,VEGFA
GO:0050793	regulation of developmental process	33	2648	0.56	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,SORL1,ICAM1,SEMA3A,PML,WNT3A,ACE,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,IL6R,NGF,ANGPTL3,FNDC5,DKK1,TLR4,EDN1,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,VEGFA
GO:1902533	positive regulation of intracellular signal transduction	22	1041	0.79	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,ICAM1,SEMA3A,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0010033	response to organic substance	35	3011	0.53	TGFB1,EPOR,HGF,MPO,CCL2,CHI3L1,FABP4,LRP6,UCP1,ICAM1,PML,WNT3A,TNFRSF11B,IGF1,CXCL8,MMP14,AKR1B10,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,THBD,EDN1,AVP,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0048519	negative regulation of biological process	46	5389	0.4	CEACAM6,TGFB1,HGF,MPO,CCL2,APOE,CRP,FABP4,MTNR1B,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,IGF1,CXCL8,MMP14,CYP2D6,CTGF,APOA2,IL6R,NGF,CD40LG,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA
GO:1901700	response to oxygen-containing compound	26	1567	0.69	TGFB1,MPO,CCL2,APOE,LRP6,UCP1,ICAM1,WNT3A,IGF1,CXCL8,HBA1,AKR1B10,CTGF,APOA2,DKK1,TLR4,TXN,THBD,EDN1,AVP,SOD3,SPP1,INS,ADIPOQ,TNF,FGF21
GO:0045860	positive regulation of protein kinase activity	17	550	0.96	TGFB1,HGF,CHI3L1,WNT3A,ACE,IGF1,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ADIPOQ,TNF,VEGFA
GO:0009893	positive regulation of metabolic process	39	3893	0.47	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA,C19orf80
GO:0022603	regulation of anatomical structure morphogenesis	22	1095	0.77	TGFB1,HGF,CCL2,APOE,CHI3L1,ICAM1,SEMA3A,PML,WNT3A,TNFRSF11B,ANGPTL4,LRG1,CXCL8,NGF,ANGPTL3,DKK1,EDN1,SPP1,ITGB2,ADIPOQ,TNF,VEGFA
GO:0043085	positive regulation of catalytic activity	25	1489	0.69	TGFB1,HGF,CCL2,APOE,CHI3L1,SORL1,ICAM1,PML,WNT3A,ACE,IGF1,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ITGB2,ADIPOQ,TNF,VEGFA
GO:0051049	regulation of transport	27	1776	0.65	TGFB1,CCL2,APOE,MTNR1B,SORL1,ICAM1,PML,WNT3A,PTX3,IGF1,APOA2,CD40LG,MBL2,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,FGF21,VEGFA
GO:0048585	negative regulation of response to stimulus	26	1636	0.67	TGFB1,HGF,CCL2,APOE,MTNR1B,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,WNT3A,IGF1,CXCL8,MMP14,APOA2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ADIPOQ,TNF
GO:0051241	negative regulation of multicellular organismal process	23	1231	0.74	TGFB1,HGF,APOE,MTNR1B,SORL1,KLKB1,SEMA3A,PML,WNT3A,TNFRSF11B,IGF1,APOA2,IL6R,DKK1,TLR4,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ADIPOQ,TNF
GO:0009967	positive regulation of signal transduction	26	1654	0.66	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,SORL1,ICAM1,SEMA3A,PML,WNT3A,LRG1,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0002682	regulation of immune system process	25	1514	0.68	TGFB1,CCL2,APOE,CRP,ICAM1,PML,PLA2G7,WNT3A,ACE,IGF1,CXCL8,MMP14,APOA2,IL6R,CD40LG,MBL2,TLR4,EDN1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,VEGFA
GO:0042981	regulation of apoptotic process	25	1550	0.67	CEACAM6,HGF,MPO,CCL2,APOE,MTNR1B,LRP6,ICAM1,PML,WNT3A,ALB,ANGPTL4,IGF1,CTGF,NGF,CD40LG,DKK1,EDN1,AVP,INS,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA
GO:0051347	positive regulation of transferase activity	18	705	0.87	TGFB1,HGF,CHI3L1,SORL1,WNT3A,ACE,IGF1,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ADIPOQ,TNF,VEGFA
GO:0030335	positive regulation of cell migration	16	522	0.95	CEACAM6,TGFB1,HGF,ICAM1,SEMA3A,PLA2G7,IGF1,CXCL8,MMP14,IL6R,ANGPTL3,EDN1,INS,TNF,GPI,VEGFA
GO:0006950	response to stress	36	3485	0.48	TGFB1,MPO,CCL2,APOE,CRP,CHI3L1,UCP1,KLKB1,ICAM1,PML,WNT3A,ALB,PTX3,ANGPTL4,IGF1,CXCL8,MMP14,HBA1,CTGF,APOA2,IL6R,CD40LG,MBL2,TLR4,TXN,THBD,EDN1,AVP,SOD3,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:2000026	regulation of multicellular organismal development	28	2096	0.59	TGFB1,HGF,APOE,CHI3L1,SORL1,SEMA3A,PML,WNT3A,ACE,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,IL6R,NGF,ANGPTL3,DKK1,TLR4,EDN1,LAMA1,SPP1,ITGB2,ADIPOQ,TNF,VEGFA
GO:0048523	negative regulation of cellular process	42	4874	0.4	CEACAM6,TGFB1,HGF,MPO,CCL2,APOE,CRP,FABP4,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,ALB,PTX3,ANGPTL4,IGF1,CXCL8,MMP14,CYP2D6,CTGF,APOA2,NGF,CD40LG,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA
GO:1902531	regulation of intracellular signal transduction	26	1807	0.62	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,ICAM1,SEMA3A,PML,IGF1,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,C1QTNF3,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0065009	regulation of molecular function	42	4913	0.4	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,TNFRSF11B,ANGPTL4,IGF1,CXCL8,CYP2D6,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,DKK1,TLR4,TXN,EDN1,AVP,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0044093	positive regulation of molecular function	26	1842	0.62	TGFB1,HGF,CCL2,APOE,CHI3L1,SORL1,LRP6,ICAM1,PML,WNT3A,ACE,IGF1,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,INS,ITGB2,ADIPOQ,TNF,VEGFA
GO:0051716	cellular response to stimulus	48	6489	0.33	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,ICAM1,SEMA3A,PML,WNT3A,ALB,TNFRSF11B,IGF1,CXCL8,HBA1,AKR1B10,CYP2D6,MOK,CTGF,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,DKK1,TLR4,TXN,EDN1,AVP,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0043405	regulation of MAP kinase activity	13	342	1.05	TGFB1,HGF,APOE,SORL1,IGF1,NGF,CD40LG,DKK1,TLR4,EDN1,ADIPOQ,TNF,VEGFA
GO:0044092	negative regulation of molecular function	21	1163	0.72	HGF,APOE,FABP4,MTNR1B,SORL1,LRP6,PML,ACE,PTX3,ANGPTL4,CYP2D6,APOA2,NGF,ANGPTL3,DKK1,AVP,INS,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0002684	positive regulation of immune system process	19	949	0.77	TGFB1,CCL2,CRP,ICAM1,PLA2G7,WNT3A,IGF1,CXCL8,MMP14,IL6R,CD40LG,MBL2,TLR4,EDN1,ITGB2,MUC16,TNF,GPI,VEGFA
GO:0050794	regulation of cellular process	61	10932	0.21	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,CYP2D6,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,TNFAIP8,ENO2,FGF21,VEGFA,C19orf80
GO:0051179	localization	44	5591	0.36	CEACAM6,TGFB1,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,ICAM1,SEMA3A,PML,WNT3A,ACE,ALB,PTX3,NGB,LRG1,IGF1,CXCL8,MMP14,NAGPA,HBA1,CTGF,APOA2,IL6R,CD40LG,ANGPTL3,MBL2,TLR4,TXN,THBD,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,GPI,VEGFA
GO:1903530	regulation of secretion by cell	16	630	0.87	TGFB1,APOE,MTNR1B,SORL1,IGF1,CD40LG,TLR4,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,GPI
GO:0032102	negative regulation of response to external stimulus	13	367	1.01	HGF,CCL2,APOE,KLKB1,SEMA3A,WNT3A,THBD,EDN1,C1QTNF3,SPP1,INS,ADIPOQ,TNF
GO:0042127	regulation of cell population proliferation	24	1642	0.63	CEACAM6,TGFB1,CCL2,APOE,CRP,LRP6,PML,WNT3A,ACE,LRG1,IGF1,CXCL8,CTGF,IL6R,NGF,CD40LG,TLR4,EDN1,AVP,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0033993	response to lipid	18	858	0.79	TGFB1,MPO,CCL2,LRP6,UCP1,ICAM1,WNT3A,CXCL8,CTGF,APOA2,DKK1,TLR4,THBD,EDN1,AVP,SPP1,ADIPOQ,TNF
GO:0031325	positive regulation of cellular metabolic process	34	3413	0.46	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,LRP6,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA,C19orf80
GO:0051173	positive regulation of nitrogen compound metabolic process	33	3239	0.47	TGFB1,HGF,CCL2,APOE,CHI3L1,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA,C19orf80
GO:1903532	positive regulation of secretion by cell	12	312	1.05	TGFB1,SORL1,IGF1,TLR4,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,TNF,GPI
GO:0003018	vascular process in circulatory system	10	185	1.2	TGFB1,APOE,CRP,MTNR1B,ICAM1,ACE,EDN1,AVP,INS,VEGFA
GO:0009966	regulation of signal transduction	32	3107	0.48	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,LRG1,IGF1,CXCL8,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:2000377	regulation of reactive oxygen species metabolic process	10	188	1.19	TGFB1,CRP,UCP1,ICAM1,PTX3,TLR4,EDN1,INS,ITGB2,TNF
GO:0009719	response to endogenous stimulus	22	1447	0.65	TGFB1,CCL2,LRP6,UCP1,ICAM1,PML,TNFRSF11B,IGF1,CXCL8,MMP14,CTGF,APOA2,NGF,ANGPTL3,TLR4,EDN1,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21
GO:0043086	negative regulation of catalytic activity	17	807	0.79	HGF,APOE,FABP4,SORL1,LRP6,PML,PTX3,ANGPTL4,APOA2,NGF,ANGPTL3,AVP,INS,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	11	258	1.1	TGFB1,HGF,ICAM1,WNT3A,ACE,IGF1,IL6R,ITGB2,ADIPOQ,TNF,VEGFA
GO:0032880	regulation of protein localization	18	934	0.75	TGFB1,APOE,MTNR1B,SORL1,PML,WNT3A,IGF1,MMP14,CD40LG,TLR4,TXN,C1QTNF3,INS,ITGB2,ADIPOQ,TNF,GPI,VEGFA
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10	196	1.17	TGFB1,HGF,ICAM1,WNT3A,ACE,IGF1,IL6R,ADIPOQ,TNF,VEGFA
GO:0030198	extracellular matrix organization	12	338	1.02	TGFB1,KLKB1,ICAM1,WNT3A,PTX3,TNFRSF11B,MMP14,CTGF,LAMA1,SPP1,ITGB2,TNF
GO:0051129	negative regulation of cellular component organization	16	713	0.82	TGFB1,HGF,APOE,SORL1,SEMA3A,PML,WNT3A,ACE,IGF1,MMP14,APOA2,DKK1,AVP,SPP1,TNF,VEGFA
GO:1903426	regulation of reactive oxygen species biosynthetic process	8	95	1.39	UCP1,ICAM1,PTX3,TLR4,EDN1,INS,ITGB2,TNF
GO:0001558	regulation of cell growth	13	423	0.95	TGFB1,APOE,SEMA3A,PML,WNT3A,IGF1,MMP14,NGF,EDN1,AVP,SPP1,INS,VEGFA
GO:0010604	positive regulation of macromolecule metabolic process	34	3600	0.44	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,SORL1,LRP6,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ADIPOQ,TNF,FGF21,VEGFA,C19orf80
GO:0033135	regulation of peptidyl-serine phosphorylation	9	146	1.26	TGFB1,HGF,WNT3A,NGF,DKK1,TXN,AVP,TNF,VEGFA
GO:0071900	regulation of protein serine/threonine kinase activity	14	521	0.89	TGFB1,HGF,APOE,SORL1,LRP6,IGF1,NGF,CD40LG,DKK1,TLR4,EDN1,ADIPOQ,TNF,VEGFA
GO:0051248	negative regulation of protein metabolic process	19	1096	0.7	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,PML,PTX3,IGF1,NGF,DKK1,TLR4,EDN1,AVP,INS,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0070374	positive regulation of ERK1 and ERK2 cascade	10	209	1.15	TGFB1,CCL2,APOE,CHI3L1,ICAM1,CTGF,TLR4,TNF,FGF21,VEGFA
GO:0009617	response to bacterium	15	634	0.84	TGFB1,MPO,CCL2,CRP,FABP4,ICAM1,LRG1,CXCL8,IL6R,MBL2,TLR4,THBD,EDN1,ADIPOQ,TNF
GO:0007166	cell surface receptor signaling pathway	27	2325	0.53	TGFB1,EPOR,HGF,CCL2,LRP6,ICAM1,SEMA3A,PML,WNT3A,TNFRSF11B,IGF1,CXCL8,CTGF,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,EDN1,LAMA1,INS,ITGB2,MUC16,TNF,FGF21,VEGFA
GO:0045834	positive regulation of lipid metabolic process	9	152	1.24	TGFB1,APOE,APOA2,ANGPTL3,AVP,INS,ADIPOQ,TNF,FGF21
GO:0042592	homeostatic process	23	1676	0.6	MPO,CCL2,APOE,FABP4,MTNR1B,LRP6,ICAM1,PML,ALB,ANGPTL4,CTGF,APOA2,ANGPTL3,TLR4,TXN,EDN1,AVP,C1QTNF3,INS,ADIPOQ,FGF21,VEGFA,C19orf80
GO:2000379	positive regulation of reactive oxygen species metabolic process	8	103	1.36	TGFB1,CRP,ICAM1,PTX3,TLR4,EDN1,ITGB2,TNF
GO:0030162	regulation of proteolysis	16	747	0.8	HGF,APOE,SORL1,DESI1,KLKB1,PML,WNT3A,MMP14,CTGF,NGF,AVP,INS,TNF,TNFAIP8,VEGFA,C19orf80
GO:0010628	positive regulation of gene expression	27	2337	0.53	TGFB1,HGF,APOE,CRP,SORL1,LRP6,KLKB1,PML,WNT3A,IGF1,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,EDN1,AVP,C1QTNF3,SPP1,INS,ADIPOQ,TNF,VEGFA,C19orf80
GO:0071310	cellular response to organic substance	27	2369	0.52	TGFB1,EPOR,HGF,CCL2,CHI3L1,FABP4,LRP6,UCP1,ICAM1,PML,WNT3A,TNFRSF11B,IGF1,CXCL8,CTGF,IL6R,NGF,CD40LG,TLR4,EDN1,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0010646	regulation of cell communication	33	3514	0.44	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,LRG1,IGF1,CXCL8,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0070372	regulation of ERK1 and ERK2 cascade	11	292	1.04	TGFB1,CCL2,APOE,CHI3L1,ICAM1,CTGF,TLR4,ADIPOQ,TNF,FGF21,VEGFA
GO:0023051	regulation of signaling	33	3553	0.43	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,LRG1,IGF1,CXCL8,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ADIPOQ,TNF,FGF21,VEGFA
GO:0007165	signal transduction	39	4876	0.37	CEACAM6,TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,TNFRSF11B,IGF1,CXCL8,MOK,CTGF,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,DKK1,TLR4,EDN1,AVP,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0080134	regulation of response to stress	21	1437	0.63	HGF,APOE,FABP4,KLKB1,SEMA3A,PML,PLA2G7,CTGF,CD40LG,DKK1,TLR4,TXN,THBD,EDN1,C1QTNF3,SPP1,INS,MUC16,ADIPOQ,TNF,VEGFA
GO:0006952	defense response	20	1296	0.65	TGFB1,MPO,CCL2,CRP,CHI3L1,KLKB1,ICAM1,PML,PTX3,CXCL8,APOA2,IL6R,CD40LG,MBL2,TLR4,EDN1,SPP1,INS,ITGB2,TNF
GO:0002526	acute inflammatory response	7	74	1.44	CRP,KLKB1,ICAM1,APOA2,IL6R,MBL2,INS
GO:1901701	cellular response to oxygen-containing compound	18	1055	0.7	TGFB1,MPO,CCL2,LRP6,UCP1,ICAM1,WNT3A,IGF1,CXCL8,AKR1B10,TLR4,EDN1,SOD3,SPP1,INS,ADIPOQ,TNF,FGF21
GO:1901214	regulation of neuron death	11	317	1.01	CCL2,APOE,MTNR1B,SORL1,WNT3A,NGF,DKK1,TLR4,ITGB2,TNF,FGF21
GO:0065007	biological regulation	62	12171	0.17	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,HBA1,AKR1B10,CYP2D6,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,TNFAIP8,ENO2,FGF21,VEGFA,C19orf80
GO:0030155	regulation of cell adhesion	15	712	0.79	CEACAM6,TGFB1,CCL2,ICAM1,PML,WNT3A,IGF1,CXCL8,MMP14,CD40LG,LAMA1,ITGB2,ADIPOQ,TNF,VEGFA
GO:0045429	positive regulation of nitric oxide biosynthetic process	6	44	1.6	ICAM1,PTX3,TLR4,EDN1,ITGB2,TNF
GO:0050708	regulation of protein secretion	11	333	0.98	TGFB1,APOE,MTNR1B,SORL1,IGF1,CD40LG,TLR4,C1QTNF3,INS,TNF,GPI
GO:0051223	regulation of protein transport	14	617	0.82	TGFB1,APOE,MTNR1B,SORL1,IGF1,CD40LG,TLR4,TXN,C1QTNF3,INS,ITGB2,ADIPOQ,TNF,GPI
GO:0034097	response to cytokine	18	1101	0.68	TGFB1,EPOR,HGF,CCL2,CHI3L1,FABP4,ICAM1,PML,TNFRSF11B,CXCL8,IL6R,CD40LG,TLR4,EDN1,ITGB2,ADIPOQ,TNF,VEGFA
GO:0090066	regulation of anatomical structure size	13	516	0.87	APOE,CRP,MTNR1B,ICAM1,SEMA3A,WNT3A,ACE,NGF,EDN1,AVP,SPP1,INS,VEGFA
GO:1904018	positive regulation of vasculature development	9	189	1.14	HGF,CHI3L1,ANGPTL4,LRG1,CXCL8,IL6R,ANGPTL3,ITGB2,VEGFA
GO:1901342	regulation of vasculature development	11	336	0.98	HGF,CHI3L1,PML,ANGPTL4,LRG1,CXCL8,IL6R,ANGPTL3,ITGB2,TNF,VEGFA
GO:0019216	regulation of lipid metabolic process	12	424	0.92	TGFB1,APOE,SORL1,ANGPTL4,APOA2,ANGPTL3,AVP,INS,ADIPOQ,TNF,FGF21,C19orf80
GO:0035295	tube development	16	851	0.74	TGFB1,CCL2,APOE,CHI3L1,LRP6,PML,WNT3A,ANGPTL4,CXCL8,MMP14,CTGF,ANGPTL3,EDN1,LAMA1,TNF,VEGFA
GO:0007154	cell communication	40	5320	0.34	CEACAM6,TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ALB,TNFRSF11B,IGF1,CXCL8,MOK,CTGF,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,DKK1,TLR4,EDN1,AVP,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,FGF21,VEGFA,C19orf80
GO:0001817	regulation of cytokine production	15	742	0.77	TGFB1,HGF,CRP,SORL1,PML,WNT3A,IGF1,APOA2,IL6R,CD40LG,TLR4,C1QTNF3,INS,ADIPOQ,TNF
GO:0032502	developmental process	42	5841	0.32	TGFB1,EPOR,HGF,MPO,CCL2,APOE,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,TNFRSF11B,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,MBL2,DKK1,TLR4,EDN1,C1QTNF3,LAMA1,SPP1,ITGB2,ADIPOQ,TNF,VEGFA,C19orf80
GO:0043406	positive regulation of MAP kinase activity	10	265	1.04	TGFB1,HGF,IGF1,NGF,CD40LG,DKK1,TLR4,EDN1,TNF,VEGFA
GO:0045597	positive regulation of cell differentiation	17	993	0.7	TGFB1,HGF,APOE,SEMA3A,WNT3A,IGF1,MMP14,CTGF,IL6R,NGF,FNDC5,DKK1,EDN1,INS,ADIPOQ,TNF,VEGFA
GO:0071902	positive regulation of protein serine/threonine kinase activity	11	348	0.97	TGFB1,HGF,IGF1,NGF,CD40LG,DKK1,TLR4,EDN1,ADIPOQ,TNF,VEGFA
GO:0032501	multicellular organismal process	46	6933	0.29	TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,ALB,PTX3,TNFRSF11B,ANGPTL4,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,MBL2,DKK1,TLR4,THBD,EDN1,AVP,LAMA1,SPP1,INS,ITGB2,ADIPOQ,TNF,VEGFA
GO:0034612	response to tumor necrosis factor	10	269	1.04	CCL2,CHI3L1,FABP4,ICAM1,TNFRSF11B,CXCL8,CD40LG,EDN1,ADIPOQ,TNF
GO:2000351	regulation of endothelial cell apoptotic process	6	50	1.54	CCL2,ICAM1,ANGPTL4,CD40LG,TNF,FGF21
GO:0097746	regulation of blood vessel diameter	8	139	1.23	APOE,CRP,MTNR1B,ICAM1,ACE,EDN1,AVP,INS
GO:0051091	positive regulation of DNA-binding transcription factor activity	10	271	1.03	LRP6,ICAM1,WNT3A,CD40LG,TLR4,EDN1,INS,ITGB2,TNF,VEGFA
GO:0009628	response to abiotic stimulus	18	1147	0.66	MPO,CHI3L1,UCP1,ICAM1,PML,ANGPTL4,IGF1,MMP14,CTGF,TLR4,TXN,THBD,EDN1,AVP,SOD3,ADIPOQ,TNF,VEGFA
GO:0055088	lipid homeostasis	8	142	1.22	APOE,FABP4,ANGPTL4,APOA2,ANGPTL3,C1QTNF3,INS,C19orf80
GO:0071345	cellular response to cytokine stimulus	17	1013	0.69	TGFB1,EPOR,HGF,CCL2,CHI3L1,FABP4,ICAM1,PML,TNFRSF11B,CXCL8,IL6R,CD40LG,TLR4,EDN1,ITGB2,TNF,VEGFA
GO:0035239	tube morphogenesis	14	656	0.79	TGFB1,CCL2,APOE,LRP6,PML,WNT3A,ANGPTL4,CXCL8,MMP14,CTGF,ANGPTL3,EDN1,LAMA1,VEGFA
GO:0002687	positive regulation of leukocyte migration	8	144	1.21	ICAM1,PLA2G7,CXCL8,MMP14,IL6R,EDN1,TNF,VEGFA
GO:0001818	negative regulation of cytokine production	10	280	1.02	TGFB1,HGF,PML,IGF1,APOA2,IL6R,TLR4,C1QTNF3,ADIPOQ,TNF
GO:0002685	regulation of leukocyte migration	9	209	1.1	CCL2,ICAM1,PLA2G7,CXCL8,MMP14,IL6R,EDN1,TNF,VEGFA
GO:0001819	positive regulation of cytokine production	12	461	0.88	TGFB1,HGF,SORL1,WNT3A,APOA2,IL6R,CD40LG,TLR4,C1QTNF3,INS,ADIPOQ,TNF
GO:0032269	negative regulation of cellular protein metabolic process	17	1043	0.68	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,PML,NGF,DKK1,TLR4,EDN1,AVP,INS,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0051098	regulation of binding	11	373	0.94	TGFB1,APOE,SORL1,WNT3A,ACE,IGF1,CYP2D6,NGF,DKK1,TXN,ADIPOQ
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	9	216	1.09	HGF,PML,WNT3A,CTGF,NGF,AVP,TNF,TNFAIP8,VEGFA
GO:0008284	positive regulation of cell population proliferation	16	919	0.71	CEACAM6,TGFB1,PML,WNT3A,LRG1,IGF1,CTGF,IL6R,CD40LG,TLR4,EDN1,AVP,INS,TNF,FGF21,VEGFA
GO:0016192	vesicle-mediated transport	22	1805	0.55	CEACAM6,TGFB1,HGF,MPO,APOE,CRP,CHI3L1,SORL1,LRP6,WNT3A,ALB,PTX3,LRG1,IGF1,CXCL8,HBA1,MBL2,TLR4,INS,ITGB2,GPI,VEGFA
GO:1990748	cellular detoxification	7	101	1.31	MPO,APOE,ALB,HBA1,AKR1B10,TXN,SOD3
GO:0030154	cell differentiation	32	3702	0.4	TGFB1,HGF,CCL2,APOE,FABP4,SORL1,LRP6,UCP1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,LRG1,IGF1,MMP14,CTGF,NGF,CD40LG,MBL2,DKK1,TLR4,EDN1,C1QTNF3,LAMA1,SPP1,ITGB2,ADIPOQ,TNF,VEGFA,C19orf80
GO:0050920	regulation of chemotaxis	9	223	1.07	TGFB1,CCL2,SEMA3A,PLA2G7,WNT3A,CXCL8,IL6R,EDN1,VEGFA
GO:0050994	regulation of lipid catabolic process	6	60	1.47	SORL1,APOA2,ANGPTL3,INS,TNF,FGF21
GO:0045765	regulation of angiogenesis	10	303	0.98	HGF,CHI3L1,PML,ANGPTL4,LRG1,CXCL8,ANGPTL3,ITGB2,TNF,VEGFA
GO:0032872	regulation of stress-activated MAPK cascade	9	228	1.06	HGF,SEMA3A,CTGF,CD40LG,DKK1,TLR4,EDN1,TNF,VEGFA
GO:0044057	regulation of system process	13	592	0.81	HGF,APOE,MTNR1B,ICAM1,SEMA3A,ACE,IGF1,CTGF,APOA2,EDN1,AVP,C1QTNF3,ADIPOQ
GO:0006979	response to oxidative stress	11	393	0.91	MPO,APOE,UCP1,PML,MMP14,HBA1,MBL2,TXN,EDN1,SOD3,ADIPOQ
GO:0008015	blood circulation	11	394	0.91	TGFB1,APOE,CRP,MTNR1B,ICAM1,ACE,EDN1,AVP,INS,ADIPOQ,VEGFA
GO:0034369	plasma lipoprotein particle remodeling	5	30	1.69	MPO,APOE,PLA2G7,ALB,APOA2
GO:0032874	positive regulation of stress-activated MAPK cascade	8	164	1.15	SEMA3A,CTGF,CD40LG,DKK1,TLR4,EDN1,TNF,VEGFA
GO:0046903	secretion	17	1097	0.66	CEACAM6,TGFB1,HGF,MPO,CHI3L1,ACE,ALB,PTX3,LRG1,IGF1,NAGPA,CTGF,CD40LG,EDN1,ITGB2,GPI,VEGFA
GO:0048731	system development	35	4426	0.36	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,TNFRSF11B,ANGPTL4,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,MBL2,DKK1,TLR4,EDN1,LAMA1,SPP1,ADIPOQ,TNF,VEGFA
GO:0010942	positive regulation of cell death	14	719	0.75	CCL2,APOE,PML,WNT3A,HBA1,CTGF,NGF,CD40LG,DKK1,TLR4,ITGB2,ADIPOQ,TNF,TNFAIP8
GO:0050714	positive regulation of protein secretion	8	167	1.15	TGFB1,SORL1,IGF1,TLR4,C1QTNF3,INS,TNF,GPI
GO:0050900	leukocyte migration	10	316	0.97	CEACAM6,TGFB1,CCL2,ICAM1,CXCL8,IL6R,THBD,ITGB2,TNF,VEGFA
GO:0045766	positive regulation of angiogenesis	8	169	1.14	HGF,CHI3L1,ANGPTL4,LRG1,CXCL8,ANGPTL3,ITGB2,VEGFA
GO:0009725	response to hormone	15	849	0.71	TGFB1,LRP6,UCP1,ICAM1,TNFRSF11B,MMP14,CTGF,APOA2,ANGPTL3,EDN1,SPP1,INS,ADIPOQ,TNF,FGF21
GO:0033138	positive regulation of peptidyl-serine phosphorylation	7	112	1.26	TGFB1,WNT3A,NGF,TXN,AVP,TNF,VEGFA
GO:0032940	secretion by cell	16	979	0.68	CEACAM6,TGFB1,HGF,MPO,CHI3L1,ALB,PTX3,LRG1,IGF1,NAGPA,CTGF,CD40LG,EDN1,ITGB2,GPI,VEGFA
GO:0030307	positive regulation of cell growth	8	171	1.14	WNT3A,IGF1,MMP14,NGF,EDN1,AVP,INS,VEGFA
GO:0048514	blood vessel morphogenesis	11	410	0.89	TGFB1,CCL2,APOE,ANGPTL4,CXCL8,MMP14,CTGF,ANGPTL3,EDN1,LAMA1,VEGFA
GO:0032103	positive regulation of response to external stimulus	12	511	0.84	TGFB1,FABP4,KLKB1,PLA2G7,CXCL8,IL6R,TLR4,THBD,EDN1,MUC16,TNF,VEGFA
GO:0048878	chemical homeostasis	17	1124	0.65	APOE,FABP4,MTNR1B,LRP6,ICAM1,PML,ANGPTL4,APOA2,ANGPTL3,EDN1,AVP,C1QTNF3,INS,ADIPOQ,FGF21,VEGFA,C19orf80
GO:0071356	cellular response to tumor necrosis factor	9	245	1.03	CCL2,CHI3L1,FABP4,ICAM1,TNFRSF11B,CXCL8,CD40LG,EDN1,TNF
GO:0022407	regulation of cell-cell adhesion	11	424	0.88	CEACAM6,TGFB1,CCL2,ICAM1,WNT3A,IGF1,CD40LG,ITGB2,ADIPOQ,TNF,VEGFA
GO:0070328	triglyceride homeostasis	5	35	1.62	APOE,ANGPTL4,ANGPTL3,C1QTNF3,C19orf80
GO:0002443	leukocyte mediated immunity	13	641	0.77	CEACAM6,MPO,CRP,CHI3L1,ICAM1,ACE,PTX3,LRG1,IL6R,CD40LG,MBL2,ITGB2,GPI
GO:2000725	regulation of cardiac muscle cell differentiation	5	36	1.61	TGFB1,WNT3A,IGF1,DKK1,EDN1
GO:1902947	regulation of tau-protein kinase activity	4	13	1.95	HGF,APOE,SORL1,DKK1
GO:0002376	immune system process	25	2481	0.47	CEACAM6,TGFB1,MPO,CCL2,CRP,CHI3L1,ICAM1,PML,WNT3A,ACE,PTX3,LRG1,CXCL8,IL6R,CD40LG,MBL2,TLR4,THBD,EDN1,INS,ITGB2,MUC16,TNF,GPI,VEGFA
GO:0080090	regulation of primary metabolic process	41	6032	0.3	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,ANGPTL4,IGF1,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0010827	regulation of glucose transmembrane transport	6	74	1.37	IGF1,EDN1,INS,ADIPOQ,TNF,FGF21
GO:0016477	cell migration	15	896	0.69	CEACAM6,TGFB1,HGF,CCL2,ICAM1,SEMA3A,PML,CXCL8,MMP14,CTGF,IL6R,THBD,ITGB2,TNF,VEGFA
GO:0006810	transport	34	4353	0.36	CEACAM6,TGFB1,HGF,MPO,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,PML,WNT3A,ACE,ALB,PTX3,NGB,LRG1,IGF1,CXCL8,NAGPA,HBA1,CTGF,APOA2,CD40LG,MBL2,TLR4,EDN1,AVP,INS,ITGB2,GPI,VEGFA
GO:0097006	regulation of plasma lipoprotein particle levels	6	75	1.37	MPO,APOE,PLA2G7,ALB,APOA2,ADIPOQ
GO:0032677	regulation of interleukin-8 production	6	76	1.36	CRP,APOA2,IL6R,TLR4,ADIPOQ,TNF
GO:0050727	regulation of inflammatory response	10	351	0.92	HGF,APOE,FABP4,KLKB1,PLA2G7,TLR4,C1QTNF3,INS,ADIPOQ,TNF
GO:0060627	regulation of vesicle-mediated transport	12	550	0.8	CCL2,APOE,SORL1,WNT3A,PTX3,APOA2,MBL2,DKK1,ITGB2,ADIPOQ,TNF,VEGFA
GO:0051346	negative regulation of hydrolase activity	11	450	0.85	HGF,SORL1,PTX3,ANGPTL4,APOA2,NGF,ANGPTL3,AVP,TNF,TNFAIP8,VEGFA
GO:0010720	positive regulation of cell development	12	556	0.8	TGFB1,HGF,APOE,SEMA3A,WNT3A,IGF1,NGF,DKK1,EDN1,ADIPOQ,TNF,VEGFA
GO:0006915	apoptotic process	15	918	0.68	CEACAM6,TGFB1,CHI3L1,SEMA3A,PML,TNFRSF11B,NGB,IL6R,NGF,TLR4,AVP,ITGB2,TNF,TNFAIP8,FGF21
GO:0034374	low-density lipoprotein particle remodeling	4	15	1.89	MPO,APOE,PLA2G7,APOA2
GO:0019221	cytokine-mediated signaling pathway	13	678	0.75	TGFB1,EPOR,HGF,CCL2,ICAM1,PML,TNFRSF11B,CXCL8,IL6R,CD40LG,ITGB2,TNF,VEGFA
GO:0019222	regulation of metabolic process	44	6948	0.27	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,ANGPTL4,IGF1,MMP14,CYP2D6,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0001775	cell activation	16	1075	0.64	CEACAM6,MPO,CHI3L1,ICAM1,WNT3A,PTX3,LRG1,IGF1,CXCL8,CD40LG,TLR4,EDN1,INS,ITGB2,TNF,GPI
GO:0046330	positive regulation of JNK cascade	7	137	1.17	SEMA3A,CTGF,CD40LG,DKK1,TLR4,EDN1,TNF
GO:0010648	negative regulation of cell communication	18	1382	0.58	TGFB1,HGF,APOE,MTNR1B,SORL1,LRP6,ICAM1,IGF1,CXCL8,MMP14,DKK1,TLR4,EDN1,AVP,C1QTNF3,INS,ADIPOQ,TNF
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	6	85	1.31	HGF,NGF,AVP,TNF,TNFAIP8,VEGFA
GO:1903035	negative regulation of response to wounding	6	85	1.31	APOE,KLKB1,THBD,EDN1,SPP1,TNF
GO:0023057	negative regulation of signaling	18	1385	0.58	TGFB1,HGF,APOE,MTNR1B,SORL1,LRP6,ICAM1,IGF1,CXCL8,MMP14,DKK1,TLR4,EDN1,AVP,C1QTNF3,INS,ADIPOQ,TNF
GO:0045595	regulation of cell differentiation	21	1874	0.51	TGFB1,HGF,APOE,CRP,SORL1,SEMA3A,WNT3A,IGF1,MMP14,CTGF,IL6R,NGF,FNDC5,DKK1,TLR4,EDN1,SPP1,INS,ADIPOQ,TNF,VEGFA
GO:0032147	activation of protein kinase activity	10	376	0.89	HGF,CHI3L1,IGF1,NGF,CD40LG,TLR4,TXN,INS,TNF,VEGFA
GO:0060284	regulation of cell development	15	956	0.66	TGFB1,HGF,APOE,SORL1,SEMA3A,WNT3A,IGF1,NGF,DKK1,EDN1,SPP1,INS,ADIPOQ,TNF,VEGFA
GO:0048513	animal organ development	28	3197	0.41	TGFB1,EPOR,HGF,CCL2,CHI3L1,MTNR1B,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,CD40LG,MBL2,DKK1,EDN1,LAMA1,SPP1,ADIPOQ,TNF,VEGFA
GO:0031323	regulation of cellular metabolic process	41	6239	0.28	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,CYP2D6,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0040011	locomotion	17	1251	0.6	CEACAM6,TGFB1,HGF,CCL2,ICAM1,SEMA3A,PML,WNT3A,CXCL8,MMP14,CTGF,IL6R,THBD,LAMA1,ITGB2,TNF,VEGFA
GO:0002252	immune effector process	15	969	0.66	CEACAM6,MPO,CRP,CHI3L1,ICAM1,PML,ACE,PTX3,LRG1,IL6R,CD40LG,MBL2,TLR4,ITGB2,GPI
GO:0051707	response to other organism	17	1256	0.6	TGFB1,MPO,CCL2,CRP,FABP4,ICAM1,PML,PTX3,LRG1,CXCL8,IL6R,MBL2,TLR4,THBD,EDN1,ADIPOQ,TNF
GO:0098869	cellular oxidant detoxification	6	90	1.29	MPO,APOE,ALB,HBA1,TXN,SOD3
GO:0007275	multicellular organism development	36	5023	0.32	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,TNFRSF11B,ANGPTL4,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,MBL2,DKK1,TLR4,EDN1,LAMA1,SPP1,ITGB2,ADIPOQ,TNF,VEGFA
GO:0009968	negative regulation of signal transduction	17	1271	0.59	TGFB1,HGF,APOE,MTNR1B,SORL1,LRP6,ICAM1,IGF1,CXCL8,MMP14,DKK1,TLR4,AVP,C1QTNF3,INS,ADIPOQ,TNF
GO:0051093	negative regulation of developmental process	15	983	0.65	TGFB1,APOE,CRP,SORL1,SEMA3A,PML,WNT3A,TNFRSF11B,IGF1,DKK1,TLR4,SPP1,ADIPOQ,TNF,VEGFA
GO:0050764	regulation of phagocytosis	6	92	1.28	CCL2,PTX3,APOA2,MBL2,ADIPOQ,TNF
GO:2000727	positive regulation of cardiac muscle cell differentiation	4	19	1.79	TGFB1,WNT3A,IGF1,EDN1
GO:0045596	negative regulation of cell differentiation	13	728	0.72	TGFB1,APOE,CRP,SORL1,SEMA3A,WNT3A,IGF1,DKK1,TLR4,SPP1,ADIPOQ,TNF,VEGFA
GO:1905952	regulation of lipid localization	7	151	1.13	APOE,CRP,APOA2,EDN1,SPP1,ADIPOQ,TNF
GO:0051336	regulation of hydrolase activity	17	1284	0.59	HGF,CCL2,SORL1,ICAM1,PML,WNT3A,PTX3,ANGPTL4,CTGF,APOA2,NGF,ANGPTL3,AVP,TNF,TNFAIP8,VEGFA,C19orf80
GO:0080135	regulation of cellular response to stress	13	739	0.71	HGF,SEMA3A,PML,CTGF,CD40LG,DKK1,TLR4,TXN,EDN1,SPP1,INS,TNF,VEGFA
GO:0072359	circulatory system development	14	872	0.67	TGFB1,EPOR,CCL2,APOE,LRP6,WNT3A,ANGPTL4,CXCL8,MMP14,CTGF,ANGPTL3,EDN1,LAMA1,VEGFA
GO:0032496	response to lipopolysaccharide	9	313	0.92	TGFB1,MPO,CCL2,ICAM1,CXCL8,TLR4,THBD,EDN1,TNF
GO:0022612	gland morphogenesis	6	99	1.25	TGFB1,LRP6,SEMA3A,PML,LAMA1,TNF
GO:0061138	morphogenesis of a branching epithelium	7	159	1.11	LRP6,SEMA3A,PML,MMP14,EDN1,LAMA1,VEGFA
GO:0009892	negative regulation of metabolic process	27	3124	0.4	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,PML,ACE,PTX3,IGF1,CYP2D6,CTGF,APOA2,IL6R,NGF,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0051235	maintenance of location	7	161	1.1	APOE,SORL1,PML,ALB,ANGPTL3,TXN,TNF
GO:0060255	regulation of macromolecule metabolic process	41	6407	0.27	TGFB1,HGF,CCL2,APOE,CRP,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0002697	regulation of immune effector process	10	418	0.84	TGFB1,ICAM1,PML,APOA2,CD40LG,TLR4,INS,ITGB2,TNF,GPI
GO:0010817	regulation of hormone levels	11	524	0.79	MTNR1B,ACE,AKR1B10,CYP2D6,NGF,EDN1,C1QTNF3,SPP1,INS,ADIPOQ,TNF
GO:0048856	anatomical structure development	37	5402	0.3	TGFB1,EPOR,HGF,CCL2,APOE,CHI3L1,MTNR1B,SORL1,LRP6,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,TNFRSF11B,ANGPTL4,IGF1,CXCL8,MMP14,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,MBL2,DKK1,TLR4,EDN1,LAMA1,SPP1,ITGB2,ADIPOQ,TNF,VEGFA,C19orf80
GO:0051153	regulation of striated muscle cell differentiation	6	102	1.23	TGFB1,WNT3A,IGF1,MMP14,DKK1,EDN1
GO:0052548	regulation of endopeptidase activity	10	418	0.84	HGF,SORL1,PML,WNT3A,CTGF,NGF,AVP,TNF,TNFAIP8,VEGFA
GO:0071396	cellular response to lipid	11	528	0.78	TGFB1,CCL2,LRP6,UCP1,ICAM1,WNT3A,CXCL8,TLR4,EDN1,SPP1,TNF
GO:0046324	regulation of glucose import	5	56	1.42	IGF1,INS,ADIPOQ,TNF,FGF21
GO:0010721	negative regulation of cell development	9	330	0.9	APOE,SORL1,SEMA3A,WNT3A,IGF1,DKK1,SPP1,TNF,VEGFA
GO:0045444	fat cell differentiation	6	106	1.22	FABP4,UCP1,LRG1,C1QTNF3,ADIPOQ,C19orf80
GO:1903034	regulation of response to wounding	7	169	1.08	APOE,KLKB1,TLR4,THBD,EDN1,SPP1,TNF
GO:0050995	negative regulation of lipid catabolic process	4	24	1.69	SORL1,APOA2,INS,TNF
GO:0007155	cell adhesion	14	925	0.65	CEACAM6,CCL2,LRP6,ICAM1,WNT3A,ANGPTL4,CTGF,CD40LG,ANGPTL3,LAMA1,SPP1,ITGB2,MUC16,TNF
GO:0043388	positive regulation of DNA binding	5	59	1.39	TGFB1,WNT3A,IGF1,NGF,TXN
GO:0050678	regulation of epithelial cell proliferation	9	339	0.89	TGFB1,CCL2,APOE,WNT3A,LRG1,IGF1,TLR4,TNF,VEGFA
GO:0051128	regulation of cellular component organization	23	2402	0.45	TGFB1,HGF,APOE,SORL1,ICAM1,SEMA3A,PML,WNT3A,ACE,IGF1,MMP14,CTGF,APOA2,NGF,DKK1,TLR4,EDN1,AVP,SPP1,INS,TNF,ENO2,VEGFA
GO:0051155	positive regulation of striated muscle cell differentiation	5	59	1.39	TGFB1,WNT3A,IGF1,MMP14,EDN1
GO:0045321	leukocyte activation	14	929	0.64	CEACAM6,MPO,CHI3L1,ICAM1,PTX3,LRG1,CXCL8,CD40LG,TLR4,EDN1,INS,ITGB2,TNF,GPI
GO:0051099	positive regulation of binding	7	175	1.07	TGFB1,APOE,WNT3A,ACE,IGF1,NGF,TXN
GO:0031347	regulation of defense response	12	674	0.72	HGF,APOE,FABP4,KLKB1,PML,PLA2G7,TLR4,C1QTNF3,INS,MUC16,ADIPOQ,TNF
GO:0050867	positive regulation of cell activation	9	346	0.88	TGFB1,CCL2,WNT3A,IGF1,MMP14,CTGF,CD40LG,TLR4,ITGB2
GO:0061387	regulation of extent of cell growth	6	113	1.19	APOE,SEMA3A,WNT3A,NGF,SPP1,VEGFA
GO:2000027	regulation of animal organ morphogenesis	8	257	0.96	HGF,PML,WNT3A,TNFRSF11B,DKK1,EDN1,TNF,VEGFA
GO:0031667	response to nutrient levels	10	449	0.81	MPO,APOE,SORL1,UCP1,ICAM1,ALB,TNFRSF11B,SPP1,ADIPOQ,FGF21
GO:0048729	tissue morphogenesis	11	561	0.76	TGFB1,LRP6,SEMA3A,PML,WNT3A,MMP14,MBL2,DKK1,EDN1,LAMA1,VEGFA
GO:0051222	positive regulation of protein transport	9	352	0.87	TGFB1,SORL1,IGF1,TLR4,C1QTNF3,INS,ITGB2,TNF,GPI
GO:0006898	receptor-mediated endocytosis	7	184	1.05	APOE,SORL1,LRP6,ALB,CXCL8,HBA1,ITGB2
GO:0008361	regulation of cell size	7	183	1.05	APOE,SEMA3A,WNT3A,NGF,EDN1,SPP1,VEGFA
GO:0010468	regulation of gene expression	34	4813	0.31	TGFB1,HGF,APOE,CRP,FABP4,SORL1,LRP6,UCP1,KLKB1,ICAM1,PML,WNT3A,ACE,IGF1,MMP14,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,VEGFA,C19orf80
GO:0036293	response to decreased oxygen levels	9	354	0.87	ICAM1,PML,ANGPTL4,MMP14,CTGF,EDN1,SOD3,ADIPOQ,VEGFA
GO:1903827	regulation of cellular protein localization	11	568	0.75	TGFB1,SORL1,PML,WNT3A,MMP14,TXN,INS,ITGB2,ADIPOQ,TNF,VEGFA
GO:0045861	negative regulation of proteolysis	9	356	0.87	HGF,SORL1,PML,NGF,AVP,INS,TNF,TNFAIP8,VEGFA
GO:0050865	regulation of cell activation	11	571	0.75	TGFB1,CCL2,APOE,WNT3A,IGF1,MMP14,CTGF,CD40LG,TLR4,THBD,ITGB2
GO:0045055	regulated exocytosis	12	697	0.7	CEACAM6,TGFB1,HGF,MPO,CHI3L1,ALB,PTX3,LRG1,IGF1,ITGB2,GPI,VEGFA
GO:0050766	positive regulation of phagocytosis	5	66	1.34	CCL2,PTX3,APOA2,MBL2,TNF
GO:0034392	negative regulation of smooth muscle cell apoptotic process	3	7	2.1	LRP6,IGF1,EDN1
GO:0006955	immune response	18	1588	0.52	CEACAM6,MPO,CCL2,CRP,CHI3L1,ICAM1,PML,PTX3,LRG1,CXCL8,IL6R,CD40LG,MBL2,TLR4,EDN1,ITGB2,TNF,GPI
GO:0009987	cellular process	65	15024	0.1	CEACAM6,TGFB1,EPOR,HGF,MPO,CCL2,APOE,CRP,CHI3L1,FABP4,MTNR1B,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,PLA2G7,WNT3A,ACE,ALB,PTX3,TNFRSF11B,NGB,ANGPTL4,LRG1,IGF1,CXCL8,MMP14,NAGPA,HBA1,AKR1B10,CYP2D6,MOK,CTGF,APOA2,IL6R,NGF,CD40LG,ANGPTL3,FNDC5,MBL2,DKK1,TLR4,TXN,THBD,EDN1,AVP,C1QTNF3,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,TNFAIP8,ENO2,FGF21,VEGFA,C19orf80
GO:0010605	negative regulation of macromolecule metabolic process	25	2875	0.4	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,PML,ACE,PTX3,IGF1,CTGF,APOA2,IL6R,NGF,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,INS,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0009888	tissue development	19	1760	0.5	TGFB1,EPOR,HGF,CHI3L1,LRP6,ICAM1,SEMA3A,PML,WNT3A,IGF1,MMP14,CTGF,MBL2,DKK1,EDN1,LAMA1,SPP1,ITGB2,VEGFA
GO:0022409	positive regulation of cell-cell adhesion	8	272	0.93	CEACAM6,CCL2,ICAM1,WNT3A,IGF1,CD40LG,ITGB2,TNF
GO:0002688	regulation of leukocyte chemotaxis	6	124	1.15	CCL2,PLA2G7,CXCL8,IL6R,EDN1,VEGFA
GO:0007435	salivary gland morphogenesis	4	30	1.59	TGFB1,SEMA3A,LAMA1,TNF
GO:0050715	positive regulation of cytokine secretion	4	30	1.59	SORL1,C1QTNF3,INS,TNF
GO:0050873	brown fat cell differentiation	4	30	1.59	FABP4,UCP1,LRG1,ADIPOQ
GO:0061045	negative regulation of wound healing	5	70	1.32	APOE,KLKB1,THBD,EDN1,TNF
GO:0030278	regulation of ossification	7	197	1.02	TGFB1,HGF,LRP6,IGF1,IL6R,DKK1,TNF
GO:0000302	response to reactive oxygen species	7	198	1.01	MPO,APOE,UCP1,HBA1,TXN,EDN1,SOD3
GO:0045862	positive regulation of proteolysis	9	377	0.84	APOE,KLKB1,PML,WNT3A,MMP14,CTGF,NGF,TNF,C19orf80
GO:1901889	negative regulation of cell junction assembly	4	32	1.56	ACE,MMP14,DKK1,TNF
GO:1902003	regulation of amyloid-beta formation	4	32	1.56	APOE,SORL1,IGF1,TNF
GO:0009653	anatomical structure morphogenesis	21	2165	0.45	TGFB1,HGF,CCL2,APOE,LRP6,SEMA3A,PML,WNT3A,ANGPTL4,CXCL8,MMP14,CTGF,NGF,ANGPTL3,MBL2,DKK1,EDN1,LAMA1,ITGB2,TNF,VEGFA
GO:0001101	response to acid chemical	6	131	1.13	ICAM1,CTGF,EDN1,TNF,FGF21,VEGFA
GO:0048754	branching morphogenesis of an epithelial tube	6	131	1.13	LRP6,PML,MMP14,EDN1,LAMA1,VEGFA
GO:0008283	cell population proliferation	10	493	0.77	HGF,LRP6,WNT3A,ACE,IGF1,MMP14,CTGF,CD40LG,TLR4,TNF
GO:0071363	cellular response to growth factor stimulus	10	494	0.77	TGFB1,HGF,CCL2,PML,CXCL8,CTGF,NGF,EDN1,FGF21,VEGFA
GO:0045598	regulation of fat cell differentiation	6	133	1.12	TGFB1,WNT3A,FNDC5,INS,ADIPOQ,TNF
GO:0008228	opsonization	3	9	1.99	CRP,PTX3,MBL2
GO:0016042	lipid catabolic process	8	294	0.9	APOE,FABP4,PLA2G7,AKR1B10,APOA2,ANGPTL3,SPP1,ADIPOQ
GO:0031663	lipopolysaccharide-mediated signaling pathway	4	34	1.54	TGFB1,CCL2,TLR4,TNF
GO:0048646	anatomical structure formation involved in morphogenesis	13	883	0.63	TGFB1,CCL2,LRP6,WNT3A,ANGPTL4,CXCL8,MMP14,CTGF,ANGPTL3,DKK1,EDN1,ITGB2,VEGFA
GO:0006928	movement of cell or subcellular component	17	1501	0.52	CEACAM6,TGFB1,HGF,CCL2,ICAM1,SEMA3A,PML,WNT3A,CXCL8,MMP14,CTGF,IL6R,THBD,LAMA1,ITGB2,TNF,VEGFA
GO:0071495	cellular response to endogenous stimulus	15	1181	0.57	TGFB1,CCL2,UCP1,ICAM1,PML,IGF1,CXCL8,CTGF,NGF,TLR4,EDN1,INS,ADIPOQ,TNF,FGF21
GO:1901215	negative regulation of neuron death	7	211	0.99	CCL2,APOE,MTNR1B,SORL1,WNT3A,NGF,FGF21
GO:0050878	regulation of body fluid levels	10	509	0.76	APOE,KLKB1,WNT3A,CD40LG,TLR4,THBD,EDN1,AVP,GPI,VEGFA
GO:0050792	regulation of viral process	7	215	0.98	APOE,CRP,PML,PTX3,CXCL8,MBL2,TNF
GO:0061041	regulation of wound healing	6	140	1.1	APOE,KLKB1,TLR4,THBD,EDN1,TNF
GO:0090322	regulation of superoxide metabolic process	4	36	1.51	TGFB1,CRP,ITGB2,TNF
GO:0009891	positive regulation of biosynthetic process	20	2040	0.46	TGFB1,HGF,CCL2,APOE,LRP6,ICAM1,PML,WNT3A,PTX3,IGF1,CTGF,TLR4,EDN1,AVP,SPP1,INS,ITGB2,TNF,FGF21,VEGFA
GO:0030193	regulation of blood coagulation	5	80	1.26	APOE,KLKB1,TLR4,THBD,EDN1
GO:1900407	regulation of cellular response to oxidative stress	5	81	1.26	HGF,TLR4,TXN,INS,TNF
GO:0060562	epithelial tube morphogenesis	8	307	0.88	TGFB1,LRP6,PML,WNT3A,MMP14,EDN1,LAMA1,VEGFA
GO:0001933	negative regulation of protein phosphorylation	9	411	0.81	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,DKK1,TLR4,ADIPOQ
GO:0014070	response to organic cyclic compound	13	911	0.62	TGFB1,CCL2,LRP6,ICAM1,MMP14,CTGF,APOA2,THBD,EDN1,AVP,SPP1,ADIPOQ,TNF
GO:0031324	negative regulation of cellular metabolic process	23	2630	0.41	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,PML,PTX3,IGF1,CYP2D6,NGF,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:0048732	gland development	9	410	0.81	TGFB1,HGF,LRP6,SEMA3A,PML,WNT3A,LAMA1,TNF,VEGFA
GO:0120161	regulation of cold-induced thermogenesis	6	144	1.09	FABP4,UCP1,TLR4,ADIPOQ,FGF21,VEGFA
GO:0043491	protein kinase B signaling	4	38	1.49	TGFB1,CCL2,IGF1,TNF
GO:0046326	positive regulation of glucose import	4	38	1.49	IGF1,INS,ADIPOQ,FGF21
GO:0097756	negative regulation of blood vessel diameter	4	38	1.49	CRP,EDN1,AVP,INS
GO:0032642	regulation of chemokine production	5	84	1.24	IL6R,TLR4,C1QTNF3,ADIPOQ,TNF
GO:0050921	positive regulation of chemotaxis	6	147	1.08	TGFB1,PLA2G7,CXCL8,IL6R,EDN1,VEGFA
GO:0051171	regulation of nitrogen compound metabolic process	37	5836	0.27	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,LRP6,UCP1,DESI1,KLKB1,ICAM1,SEMA3A,PML,WNT3A,ACE,PTX3,IGF1,MMP14,CTGF,IL6R,NGF,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,SPP1,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,FGF21,VEGFA,C19orf80
GO:0001525	angiogenesis	8	315	0.87	CCL2,ANGPTL4,CXCL8,MMP14,CTGF,ANGPTL3,EDN1,VEGFA
GO:0044419	interspecies interaction between organisms	19	1899	0.47	TGFB1,MPO,CCL2,APOE,CRP,FABP4,ICAM1,PML,PTX3,LRG1,CXCL8,APOA2,IL6R,MBL2,TLR4,THBD,EDN1,ADIPOQ,TNF
GO:0010632	regulation of epithelial cell migration	7	227	0.95	TGFB1,APOE,SEMA3A,EDN1,TNF,GPI,VEGFA
GO:0045785	positive regulation of cell adhesion	9	423	0.79	CEACAM6,CCL2,ICAM1,WNT3A,IGF1,CD40LG,ITGB2,TNF,VEGFA
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	5	87	1.22	EPOR,HGF,IGF1,INS,TNF
GO:0002700	regulation of production of molecular mediator of immune response	6	152	1.06	TGFB1,APOA2,CD40LG,TLR4,TNF,GPI
GO:0110110	positive regulation of animal organ morphogenesis	5	89	1.22	PML,WNT3A,DKK1,EDN1,VEGFA
GO:0045123	cellular extravasation	4	42	1.44	CCL2,ICAM1,ITGB2,TNF
GO:0048545	response to steroid hormone	8	328	0.85	TGFB1,ICAM1,CTGF,APOA2,EDN1,SPP1,ADIPOQ,TNF
GO:0002009	morphogenesis of an epithelium	9	435	0.78	TGFB1,LRP6,SEMA3A,PML,WNT3A,MMP14,EDN1,LAMA1,VEGFA
GO:0051651	maintenance of location in cell	5	91	1.21	APOE,SORL1,PML,ALB,TXN
GO:0002696	positive regulation of leukocyte activation	8	332	0.85	TGFB1,CCL2,WNT3A,IGF1,MMP14,CD40LG,TLR4,ITGB2
GO:0048638	regulation of developmental growth	8	333	0.85	APOE,SEMA3A,WNT3A,IGF1,NGF,EDN1,SPP1,VEGFA
GO:0051092	positive regulation of NF-kappaB transcription factor activity	6	158	1.04	ICAM1,CD40LG,TLR4,INS,ITGB2,TNF
GO:0006953	acute-phase response	4	44	1.42	CRP,IL6R,MBL2,INS
GO:0032715	negative regulation of interleukin-6 production	4	44	1.42	HGF,TLR4,C1QTNF3,TNF
GO:0051051	negative regulation of transport	9	443	0.77	APOE,MTNR1B,ICAM1,APOA2,TXN,EDN1,INS,ADIPOQ,TNF
GO:0045936	negative regulation of phosphate metabolic process	10	561	0.72	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,DKK1,TLR4,ADIPOQ,TNF
GO:0009887	animal organ morphogenesis	13	967	0.59	TGFB1,CCL2,LRP6,SEMA3A,PML,WNT3A,MMP14,CTGF,MBL2,EDN1,LAMA1,TNF,VEGFA
GO:0044087	regulation of cellular component biogenesis	13	971	0.59	TGFB1,APOE,SORL1,ICAM1,WNT3A,ACE,MMP14,CTGF,DKK1,TLR4,EDN1,TNF,VEGFA
GO:0045833	negative regulation of lipid metabolic process	5	95	1.19	APOE,SORL1,APOA2,INS,TNF
GO:0050804	modulation of chemical synaptic transmission	9	446	0.77	CCL2,APOE,WNT3A,NGF,DKK1,EDN1,INS,ADIPOQ,TNF
GO:0001666	response to hypoxia	8	342	0.83	ICAM1,PML,ANGPTL4,MMP14,EDN1,SOD3,ADIPOQ,VEGFA
GO:0002690	positive regulation of leukocyte chemotaxis	5	98	1.17	PLA2G7,CXCL8,IL6R,EDN1,VEGFA
GO:0010594	regulation of endothelial cell migration	6	164	1.03	TGFB1,APOE,EDN1,TNF,GPI,VEGFA
GO:0010951	negative regulation of endopeptidase activity	7	248	0.92	HGF,SORL1,NGF,AVP,TNF,TNFAIP8,VEGFA
GO:0031960	response to corticosteroid	6	164	1.03	ICAM1,CTGF,APOA2,EDN1,ADIPOQ,TNF
GO:0043255	regulation of carbohydrate biosynthetic process	5	97	1.18	TGFB1,IGF1,C1QTNF3,INS,ADIPOQ
GO:0120162	positive regulation of cold-induced thermogenesis	5	97	1.18	FABP4,UCP1,ADIPOQ,FGF21,VEGFA
GO:1901216	positive regulation of neuron death	5	98	1.17	APOE,DKK1,TLR4,ITGB2,TNF
GO:1902430	negative regulation of amyloid-beta formation	3	14	1.8	APOE,SORL1,IGF1
GO:1903829	positive regulation of cellular protein localization	8	342	0.83	TGFB1,SORL1,PML,WNT3A,INS,ITGB2,TNF,VEGFA
GO:1905953	negative regulation of lipid localization	4	46	1.4	APOE,CRP,APOA2,TNF
GO:0030195	negative regulation of blood coagulation	4	47	1.4	APOE,KLKB1,THBD,EDN1
GO:0045599	negative regulation of fat cell differentiation	4	48	1.39	TGFB1,WNT3A,ADIPOQ,TNF
GO:0097191	extrinsic apoptotic signaling pathway	5	100	1.16	TGFB1,PML,IL6R,NGF,TNF
GO:0002274	myeloid leukocyte activation	10	585	0.7	CEACAM6,MPO,CHI3L1,PTX3,LRG1,CXCL8,TLR4,ITGB2,TNF,GPI
GO:0031952	regulation of protein autophosphorylation	4	49	1.38	ACE,INS,ADIPOQ,VEGFA
GO:0051216	cartilage development	6	171	1.01	TGFB1,CHI3L1,LRP6,CTGF,MBL2,EDN1
GO:0051897	positive regulation of protein kinase B signaling	6	170	1.01	TGFB1,HGF,CHI3L1,TXN,INS,TNF
GO:0043117	positive regulation of vascular permeability	3	16	1.74	TGFB1,APOE,VEGFA
GO:0062014	negative regulation of small molecule metabolic process	5	104	1.15	TGFB1,APOE,C1QTNF3,INS,ADIPOQ
GO:1903076	regulation of protein localization to plasma membrane	5	104	1.15	TGFB1,WNT3A,MMP14,INS,TNF
GO:0043112	receptor metabolic process	5	105	1.14	TGFB1,SORL1,CXCL8,ITGB2,TNF
GO:0048525	negative regulation of viral process	5	105	1.14	CRP,PML,PTX3,MBL2,TNF
GO:1901652	response to peptide	9	476	0.74	LRP6,ICAM1,IGF1,CTGF,TLR4,EDN1,INS,ADIPOQ,FGF21
GO:0031400	negative regulation of protein modification process	10	602	0.69	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,DKK1,TLR4,ADIPOQ,TNF
GO:0044281	small molecule metabolic process	17	1684	0.47	TGFB1,HGF,MPO,APOE,PLA2G7,IGF1,AKR1B10,CYP2D6,APOA2,ANGPTL3,TXN,EDN1,INS,ADIPOQ,TNF,GPI,ENO2
GO:0050769	positive regulation of neurogenesis	9	479	0.74	TGFB1,HGF,APOE,SEMA3A,WNT3A,NGF,DKK1,TNF,VEGFA
GO:0051172	negative regulation of nitrogen compound metabolic process	21	2429	0.4	TGFB1,HGF,APOE,FABP4,SORL1,LRP6,PML,PTX3,IGF1,NGF,DKK1,TLR4,TXN,EDN1,AVP,INS,ITGB2,ADIPOQ,TNF,TNFAIP8,VEGFA
GO:1904705	regulation of vascular associated smooth muscle cell proliferation	4	52	1.35	IGF1,EDN1,ADIPOQ,TNF
GO:0000165	MAPK cascade	8	370	0.8	TGFB1,HGF,CCL2,IGF1,MOK,CD40LG,AVP,TNF
GO:0001541	ovarian follicle development	4	53	1.34	ICAM1,PTX3,MMP14,VEGFA
GO:0046883	regulation of hormone secretion	7	268	0.88	MTNR1B,EDN1,C1QTNF3,SPP1,INS,ADIPOQ,TNF
GO:0060192	negative regulation of lipase activity	3	17	1.71	ANGPTL4,APOA2,ANGPTL3
GO:1901222	regulation of NIK/NF-kappaB signaling	5	110	1.12	CHI3L1,TLR4,EDN1,C1QTNF3,TNF
GO:0007568	aging	7	274	0.87	MPO,ICAM1,PML,CTGF,DKK1,EDN1,ITGB2
GO:0032757	positive regulation of interleukin-8 production	4	55	1.33	APOA2,TLR4,ADIPOQ,TNF
GO:0034375	high-density lipoprotein particle remodeling	3	18	1.69	APOE,ALB,APOA2
GO:0045721	negative regulation of gluconeogenesis	3	18	1.69	C1QTNF3,INS,ADIPOQ
GO:0051023	regulation of immunoglobulin secretion	3	18	1.69	CD40LG,TNF,GPI
GO:0071222	cellular response to lipopolysaccharide	6	185	0.98	TGFB1,CCL2,ICAM1,CXCL8,TLR4,TNF
GO:0072593	reactive oxygen species metabolic process	5	112	1.12	MPO,HBA1,CTGF,EDN1,SOD3
GO:0002446	neutrophil mediated immunity	9	495	0.73	CEACAM6,MPO,CHI3L1,ACE,PTX3,LRG1,IL6R,ITGB2,GPI
GO:0007159	leukocyte cell-cell adhesion	4	56	1.32	ICAM1,CD40LG,ITGB2,TNF
GO:0019725	cellular homeostasis	12	895	0.59	MPO,CCL2,APOE,MTNR1B,LRP6,ICAM1,PML,TXN,EDN1,AVP,C1QTNF3,FGF21
GO:0050770	regulation of axonogenesis	6	187	0.97	APOE,SEMA3A,WNT3A,NGF,SPP1,VEGFA
GO:0050776	regulation of immune response	12	896	0.59	TGFB1,APOE,CRP,ICAM1,APOA2,CD40LG,MBL2,TLR4,INS,ITGB2,MUC16,TNF
GO:0051130	positive regulation of cellular component organization	14	1209	0.53	TGFB1,HGF,APOE,ICAM1,PML,WNT3A,IGF1,CTGF,NGF,TLR4,EDN1,INS,TNF,VEGFA
GO:0001501	skeletal system development	9	499	0.72	TGFB1,CHI3L1,LRP6,TNFRSF11B,IGF1,MMP14,CTGF,MBL2,EDN1
GO:0002366	leukocyte activation involved in immune response	10	626	0.67	CEACAM6,MPO,CHI3L1,ICAM1,PTX3,LRG1,CD40LG,TLR4,ITGB2,GPI
GO:0022604	regulation of cell morphogenesis	9	498	0.72	CCL2,APOE,ICAM1,SEMA3A,WNT3A,NGF,SPP1,ITGB2,VEGFA
GO:0032535	regulation of cellular component size	8	383	0.79	APOE,ICAM1,SEMA3A,WNT3A,NGF,EDN1,SPP1,VEGFA
GO:0043200	response to amino acid	5	114	1.11	ICAM1,CTGF,EDN1,TNF,FGF21
GO:0051353	positive regulation of oxidoreductase activity	4	57	1.31	APOE,EDN1,INS,TNF
GO:0006006	glucose metabolic process	5	116	1.1	INS,ADIPOQ,TNF,GPI,ENO2
GO:0032368	regulation of lipid transport	5	116	1.1	APOE,APOA2,EDN1,SPP1,ADIPOQ
GO:0051251	positive regulation of lymphocyte activation	7	286	0.85	TGFB1,CCL2,WNT3A,IGF1,MMP14,CD40LG,TLR4
GO:0051781	positive regulation of cell division	5	117	1.1	TGFB1,IGF1,EDN1,INS,VEGFA
GO:0019229	regulation of vasoconstriction	4	59	1.3	ICAM1,ACE,EDN1,AVP
GO:0032930	positive regulation of superoxide anion generation	3	20	1.64	TGFB1,CRP,ITGB2
GO:0044242	cellular lipid catabolic process	6	196	0.95	FABP4,PLA2G7,AKR1B10,APOA2,ANGPTL3,ADIPOQ
GO:0050768	negative regulation of neurogenesis	7	287	0.85	APOE,SORL1,SEMA3A,WNT3A,DKK1,SPP1,TNF
GO:0051769	regulation of nitric-oxide synthase biosynthetic process	3	20	1.64	CCL2,TLR4,EDN1
GO:1901698	response to nitrogen compound	13	1070	0.55	LRP6,ICAM1,IGF1,CTGF,TLR4,TXN,THBD,EDN1,INS,ITGB2,ADIPOQ,TNF,FGF21
GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	3	20	1.64	ICAM1,ITGB2,TNF
GO:0045912	negative regulation of carbohydrate metabolic process	4	60	1.29	TGFB1,C1QTNF3,INS,ADIPOQ
GO:0060541	respiratory system development	6	197	0.95	CHI3L1,LRP6,MMP14,CTGF,LAMA1,VEGFA
GO:1905475	regulation of protein localization to membrane	6	198	0.95	TGFB1,WNT3A,MMP14,INS,ITGB2,TNF
GO:0032722	positive regulation of chemokine production	4	61	1.28	IL6R,TLR4,ADIPOQ,TNF
GO:0048670	regulation of collateral sprouting	3	21	1.62	WNT3A,NGF,SPP1
GO:1901888	regulation of cell junction assembly	6	199	0.94	WNT3A,ACE,MMP14,DKK1,TNF,VEGFA
GO:0014910	regulation of smooth muscle cell migration	4	62	1.28	SORL1,ACE,IGF1,ADIPOQ
GO:0097529	myeloid leukocyte migration	5	123	1.07	CCL2,CXCL8,IL6R,ITGB2,VEGFA
GO:0060326	cell chemotaxis	6	204	0.93	HGF,CCL2,CXCL8,IL6R,ITGB2,VEGFA
GO:0051000	positive regulation of nitric-oxide synthase activity	3	22	1.6	APOE,INS,TNF
GO:0051004	regulation of lipoprotein lipase activity	3	22	1.6	ANGPTL4,ANGPTL3,C19orf80
GO:0051641	cellular localization	23	2967	0.35	CEACAM6,TGFB1,HGF,MPO,APOE,CHI3L1,SORL1,LRP6,DESI1,PML,WNT3A,ALB,PTX3,LRG1,IGF1,NAGPA,TXN,INS,ITGB2,ADIPOQ,TNF,GPI,VEGFA
GO:0090201	negative regulation of release of cytochrome c from mitochondria	3	22	1.6	HGF,IGF1,AVP
GO:0002576	platelet degranulation	5	129	1.05	TGFB1,HGF,ALB,IGF1,VEGFA
GO:0010869	regulation of receptor biosynthetic process	3	23	1.58	EDN1,ADIPOQ,FGF21
GO:0051649	establishment of localization in cell	20	2375	0.39	CEACAM6,TGFB1,HGF,MPO,APOE,CHI3L1,SORL1,LRP6,DESI1,PML,WNT3A,ALB,PTX3,LRG1,IGF1,NAGPA,INS,ITGB2,GPI,VEGFA
GO:0045995	regulation of embryonic development	5	130	1.05	WNT3A,IGF1,DKK1,LAMA1,ADIPOQ
GO:0040013	negative regulation of locomotion	7	310	0.82	TGFB1,CCL2,APOE,SEMA3A,WNT3A,ADIPOQ,TNF
GO:0043393	regulation of protein binding	6	212	0.92	APOE,SORL1,WNT3A,ACE,DKK1,ADIPOQ
GO:0060485	mesenchyme development	6	212	0.92	TGFB1,HGF,LRP6,SEMA3A,WNT3A,EDN1
GO:1903201	regulation of oxidative stress-induced cell death	4	67	1.24	HGF,TLR4,TXN,INS
GO:0010954	positive regulation of protein processing	3	24	1.56	KLKB1,MMP14,C19orf80
GO:0051271	negative regulation of cellular component movement	7	311	0.82	TGFB1,CCL2,APOE,SEMA3A,WNT3A,ADIPOQ,TNF
GO:0006935	chemotaxis	9	545	0.68	HGF,CCL2,SEMA3A,WNT3A,CXCL8,IL6R,LAMA1,ITGB2,VEGFA
GO:0008152	metabolic process	44	8298	0.19	TGFB1,HGF,MPO,CCL2,APOE,CHI3L1,FABP4,SORL1,UCP1,DESI1,KLKB1,PML,PLA2G7,ACE,ALB,ANGPTL4,IGF1,CXCL8,MMP14,NAGPA,HBA1,AKR1B10,CYP2D6,MOK,CTGF,APOA2,NGF,CD40LG,ANGPTL3,TLR4,TXN,EDN1,AVP,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,ENO2,C19orf80
GO:0001936	regulation of endothelial cell proliferation	5	134	1.04	CCL2,APOE,LRG1,TNF,VEGFA
GO:0010629	negative regulation of gene expression	18	2014	0.42	TGFB1,HGF,APOE,FABP4,PML,ACE,IGF1,CTGF,APOA2,IL6R,DKK1,TLR4,TXN,EDN1,C1QTNF3,ADIPOQ,TNF,VEGFA
GO:0010633	negative regulation of epithelial cell migration	4	69	1.23	TGFB1,APOE,SEMA3A,TNF
GO:0014823	response to activity	4	69	1.23	FNDC5,EDN1,ADIPOQ,FGF21
GO:1902996	regulation of neurofibrillary tangle assembly	2	3	2.29	APOE,SORL1
GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation	2	3	2.29	ACE,TXN
GO:0002637	regulation of immunoglobulin production	4	70	1.22	TGFB1,CD40LG,TNF,GPI
GO:0002719	negative regulation of cytokine production involved in immune response	3	25	1.54	TGFB1,APOA2,TNF
GO:0032370	positive regulation of lipid transport	4	70	1.22	APOE,EDN1,SPP1,ADIPOQ
GO:0034114	regulation of heterotypic cell-cell adhesion	3	25	1.54	CEACAM6,ADIPOQ,TNF
GO:0050767	regulation of neurogenesis	11	828	0.59	TGFB1,HGF,APOE,SORL1,SEMA3A,WNT3A,NGF,DKK1,SPP1,TNF,VEGFA
GO:0051224	negative regulation of protein transport	5	135	1.03	APOE,MTNR1B,TXN,INS,ADIPOQ
GO:0120035	regulation of plasma membrane bounded cell projection organization	10	687	0.63	HGF,APOE,ICAM1,SEMA3A,WNT3A,NGF,DKK1,SPP1,INS,VEGFA
GO:0022008	neurogenesis	16	1657	0.45	TGFB1,HGF,CCL2,APOE,SORL1,LRP6,SEMA3A,WNT3A,MMP14,NGF,DKK1,TLR4,LAMA1,SPP1,TNF,VEGFA
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	5	136	1.03	PML,WNT3A,CTGF,NGF,TNF
GO:0048660	regulation of smooth muscle cell proliferation	5	136	1.03	IGF1,IL6R,EDN1,ADIPOQ,TNF
GO:0010243	response to organonitrogen compound	12	987	0.55	LRP6,ICAM1,IGF1,CTGF,TLR4,THBD,EDN1,INS,ITGB2,ADIPOQ,TNF,FGF21
GO:1903524	positive regulation of blood circulation	4	71	1.22	ICAM1,CTGF,EDN1,AVP
GO:0009749	response to glucose	5	138	1.02	ICAM1,CTGF,APOA2,ADIPOQ,FGF21
GO:0009056	catabolic process	18	2042	0.41	TGFB1,MPO,APOE,CHI3L1,FABP4,PML,PLA2G7,ACE,MMP14,HBA1,AKR1B10,CYP2D6,APOA2,ANGPTL3,SPP1,ADIPOQ,GPI,ENO2
GO:0050728	negative regulation of inflammatory response	5	139	1.02	HGF,APOE,C1QTNF3,INS,ADIPOQ
GO:0010876	lipid localization	7	326	0.8	APOE,FABP4,LRP6,ACE,APOA2,ANGPTL3,TNF
GO:0043507	positive regulation of JUN kinase activity	4	73	1.2	CD40LG,DKK1,EDN1,TNF
GO:0050996	positive regulation of lipid catabolic process	3	27	1.51	APOA2,ANGPTL3,FGF21
GO:2000679	positive regulation of transcription regulatory region DNA binding	3	27	1.51	TGFB1,WNT3A,IGF1
GO:0030595	leukocyte chemotaxis	5	142	1.01	CCL2,CXCL8,IL6R,ITGB2,VEGFA
GO:0032675	regulation of interleukin-6 production	5	142	1.01	HGF,IL6R,TLR4,C1QTNF3,TNF
GO:1903039	positive regulation of leukocyte cell-cell adhesion	6	228	0.89	CCL2,ICAM1,IGF1,CD40LG,ITGB2,TNF
GO:1901653	cellular response to peptide	7	331	0.79	ICAM1,IGF1,TLR4,EDN1,INS,ADIPOQ,FGF21
GO:0009889	regulation of biosynthetic process	28	4210	0.29	TGFB1,HGF,CCL2,APOE,FABP4,LRP6,UCP1,ICAM1,PML,WNT3A,PTX3,IGF1,CTGF,IL6R,CD40LG,DKK1,TLR4,TXN,EDN1,AVP,C1QTNF3,SPP1,INS,ITGB2,ADIPOQ,TNF,FGF21,VEGFA
GO:0048568	embryonic organ development	8	448	0.72	TGFB1,LRP6,WNT3A,CXCL8,MMP14,EDN1,TNF,VEGFA
GO:0050729	positive regulation of inflammatory response	5	144	1.01	FABP4,KLKB1,PLA2G7,TLR4,TNF
GO:0062013	positive regulation of small molecule metabolic process	5	144	1.01	IGF1,AVP,INS,ADIPOQ,TNF
GO:0002021	response to dietary excess	3	28	1.5	APOE,SORL1,UCP1
GO:0031954	positive regulation of protein autophosphorylation	3	28	1.5	ACE,INS,VEGFA
GO:0055094	response to lipoprotein particle	3	28	1.5	TLR4,ITGB2,FGF21
GO:0062012	regulation of small molecule metabolic process	8	449	0.72	TGFB1,APOE,IGF1,AVP,C1QTNF3,INS,ADIPOQ,TNF
GO:2001234	negative regulation of apoptotic signaling pathway	6	232	0.88	HGF,ICAM1,IGF1,AVP,INS,TNF
GO:0043254	regulation of protein-containing complex assembly	8	451	0.71	TGFB1,APOE,SORL1,ICAM1,DKK1,TLR4,TNF,VEGFA
GO:0034103	regulation of tissue remodeling	4	77	1.18	TGFB1,PML,TNFRSF11B,SPP1
GO:0051384	response to glucocorticoid	5	147	1	ICAM1,APOA2,EDN1,ADIPOQ,TNF
GO:0051450	myoblast proliferation	2	4	2.16	HGF,IGF1
GO:0090245	axis elongation involved in somitogenesis	2	4	2.16	LRP6,WNT3A
GO:1902952	positive regulation of dendritic spine maintenance	2	4	2.16	APOE,INS
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	5	148	0.99	CRP,ICAM1,CD40LG,MBL2,TLR4
GO:0044788	modulation by host of viral process	3	29	1.48	APOE,CRP,PTX3
GO:0045940	positive regulation of steroid metabolic process	3	29	1.48	APOE,APOA2,TNF
GO:2000352	negative regulation of endothelial cell apoptotic process	3	29	1.48	ICAM1,ANGPTL4,FGF21
GO:0035556	intracellular signal transduction	16	1712	0.44	TGFB1,HGF,CCL2,APOE,CHI3L1,PML,IGF1,CXCL8,MOK,CTGF,NGF,CD40LG,TLR4,EDN1,AVP,TNF
GO:0010977	negative regulation of neuron projection development	5	151	0.99	APOE,SEMA3A,WNT3A,DKK1,SPP1
GO:0071402	cellular response to lipoprotein particle stimulus	3	30	1.47	TLR4,ITGB2,FGF21
GO:0071542	dopaminergic neuron differentiation	3	30	1.47	LRP6,WNT3A,VEGFA
GO:0048762	mesenchymal cell differentiation	5	152	0.98	TGFB1,HGF,LRP6,SEMA3A,EDN1
GO:0009896	positive regulation of catabolic process	8	465	0.7	APOE,SORL1,IGF1,APOA2,ANGPTL3,INS,TNF,FGF21
GO:0071621	granulocyte chemotaxis	4	81	1.16	CCL2,CXCL8,ITGB2,VEGFA
GO:0005975	carbohydrate metabolic process	8	467	0.7	CHI3L1,NAGPA,ANGPTL3,INS,ADIPOQ,TNF,GPI,ENO2
GO:1903531	negative regulation of secretion by cell	5	153	0.98	APOE,MTNR1B,EDN1,INS,ADIPOQ
GO:0048841	regulation of axon extension involved in axon guidance	3	31	1.45	SEMA3A,WNT3A,VEGFA
GO:1901224	positive regulation of NIK/NF-kappaB signaling	4	82	1.15	CHI3L1,TLR4,EDN1,TNF
GO:0000187	activation of MAPK activity	5	157	0.97	HGF,IGF1,CD40LG,TLR4,TNF
GO:0032148	activation of protein kinase B activity	3	32	1.44	IGF1,TXN,INS
GO:0003008	system process	17	1942	0.41	TGFB1,CCL2,APOE,CRP,MTNR1B,ICAM1,ACE,IGF1,NGF,DKK1,TLR4,EDN1,AVP,INS,ADIPOQ,TNF,VEGFA
GO:0009996	negative regulation of cell fate specification	2	5	2.07	WNT3A,DKK1
GO:0090244	Wnt signaling pathway involved in somitogenesis	2	5	2.07	LRP6,DKK1
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	2	5	2.07	ACE,VEGFA
GO:0007369	gastrulation	5	159	0.96	LRP6,WNT3A,MMP14,DKK1,ITGB2
GO:0032651	regulation of interleukin-1 beta production	4	85	1.14	PML,IGF1,TLR4,TNF
GO:0042632	cholesterol homeostasis	4	85	1.14	APOE,FABP4,APOA2,ANGPTL3
GO:0046889	positive regulation of lipid biosynthetic process	4	85	1.14	APOE,AVP,INS,TNF
GO:0050871	positive regulation of B cell activation	4	85	1.14	TGFB1,WNT3A,MMP14,TLR4
GO:0098542	defense response to other organism	11	900	0.55	MPO,CCL2,CRP,ICAM1,PML,PTX3,IL6R,MBL2,TLR4,EDN1,TNF
GO:0071346	cellular response to interferon-gamma	5	161	0.96	CCL2,ICAM1,PML,TLR4,EDN1
GO:2001236	regulation of extrinsic apoptotic signaling pathway	5	161	0.96	HGF,ICAM1,PML,IGF1,TNF
GO:0010543	regulation of platelet activation	3	34	1.41	APOE,TLR4,THBD
GO:0045778	positive regulation of ossification	4	88	1.12	TGFB1,HGF,IGF1,IL6R
GO:0048661	positive regulation of smooth muscle cell proliferation	4	88	1.12	IGF1,IL6R,EDN1,TNF
GO:0002718	regulation of cytokine production involved in immune response	4	89	1.12	TGFB1,APOA2,TLR4,TNF
GO:0043537	negative regulation of blood vessel endothelial cell migration	3	35	1.4	TGFB1,APOE,TNF
GO:1901031	regulation of response to reactive oxygen species	3	35	1.4	HGF,TXN,TNF
GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	3	35	1.4	IGF1,EDN1,TNF
GO:0071704	organic substance metabolic process	41	7755	0.19	TGFB1,HGF,MPO,CCL2,APOE,CHI3L1,FABP4,SORL1,DESI1,KLKB1,PML,PLA2G7,ACE,ALB,ANGPTL4,IGF1,CXCL8,MMP14,NAGPA,AKR1B10,CYP2D6,MOK,CTGF,APOA2,NGF,CD40LG,ANGPTL3,TLR4,TXN,EDN1,AVP,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,ENO2,C19orf80
GO:0030336	negative regulation of cell migration	6	262	0.83	TGFB1,CCL2,APOE,SEMA3A,ADIPOQ,TNF
GO:0042119	neutrophil activation	8	497	0.67	CEACAM6,MPO,CHI3L1,PTX3,LRG1,CXCL8,ITGB2,GPI
GO:0070542	response to fatty acid	4	91	1.11	UCP1,CTGF,EDN1,ADIPOQ
GO:0007182	common-partner SMAD protein phosphorylation	2	6	1.99	TGFB1,PML
GO:0042661	regulation of mesodermal cell fate specification	2	6	1.99	WNT3A,DKK1
GO:0043615	astrocyte cell migration	2	6	1.99	CCL2,MMP14
GO:0051005	negative regulation of lipoprotein lipase activity	2	6	1.99	ANGPTL4,ANGPTL3
GO:0051970	negative regulation of transmission of nerve impulse	2	6	1.99	MTNR1B,AVP
GO:0098801	regulation of renal system process	3	36	1.39	EDN1,AVP,ADIPOQ
GO:0001503	ossification	6	265	0.82	TGFB1,WNT3A,IGF1,MMP14,CTGF,SPP1
GO:0030324	lung development	5	170	0.93	CHI3L1,MMP14,CTGF,LAMA1,VEGFA
GO:0043535	regulation of blood vessel endothelial cell migration	4	93	1.1	TGFB1,APOE,TNF,VEGFA
GO:0051702	interaction with symbiont	4	93	1.1	APOE,CRP,PTX3,MBL2
GO:0006801	superoxide metabolic process	3	37	1.37	MPO,EDN1,SOD3
GO:0019915	lipid storage	3	37	1.37	APOE,ANGPTL3,TNF
GO:0031328	positive regulation of cellular biosynthetic process	17	2005	0.39	TGFB1,HGF,APOE,LRP6,ICAM1,PML,WNT3A,PTX3,IGF1,TLR4,EDN1,AVP,SPP1,INS,ITGB2,TNF,VEGFA
GO:0032965	regulation of collagen biosynthetic process	3	37	1.37	TGFB1,CTGF,IL6R
GO:0070741	response to interleukin-6	3	37	1.37	CHI3L1,ICAM1,IL6R
GO:0007229	integrin-mediated signaling pathway	4	94	1.09	CTGF,CD40LG,ANGPTL3,ITGB2
GO:0048468	cell development	15	1629	0.43	APOE,ICAM1,SEMA3A,WNT3A,PTX3,IGF1,NGF,MBL2,DKK1,TLR4,EDN1,LAMA1,TNF,VEGFA,C19orf80
GO:0051100	negative regulation of binding	5	173	0.93	SORL1,ACE,CYP2D6,DKK1,ADIPOQ
GO:0016310	phosphorylation	13	1275	0.47	TGFB1,HGF,CCL2,PML,IGF1,MOK,CD40LG,TLR4,AVP,LAMA1,TNF,GPI,ENO2
GO:0071347	cellular response to interleukin-1	5	174	0.92	CCL2,CHI3L1,ICAM1,CXCL8,EDN1
GO:0010470	regulation of gastrulation	3	38	1.36	WNT3A,DKK1,ADIPOQ
GO:0010975	regulation of neuron projection development	8	510	0.66	HGF,APOE,SEMA3A,WNT3A,NGF,DKK1,SPP1,VEGFA
GO:0090207	regulation of triglyceride metabolic process	3	38	1.36	APOE,SORL1,FGF21
GO:0048771	tissue remodeling	4	96	1.09	TGFB1,LRP6,ACE,MMP14
GO:0006468	protein phosphorylation	11	952	0.53	TGFB1,HGF,CCL2,PML,IGF1,MOK,CD40LG,TLR4,AVP,LAMA1,TNF
GO:0048639	positive regulation of developmental growth	5	176	0.92	WNT3A,IGF1,NGF,EDN1,VEGFA
GO:0006959	humoral immune response	6	275	0.8	CCL2,CRP,CXCL8,MBL2,TNF,GPI
GO:0035282	segmentation	4	97	1.08	LRP6,SEMA3A,WNT3A,DKK1
GO:0032733	positive regulation of interleukin-10 production	3	39	1.35	HGF,CD40LG,TLR4
GO:0032885	regulation of polysaccharide biosynthetic process	3	39	1.35	TGFB1,IGF1,INS
GO:0033574	response to testosterone	3	39	1.35	EDN1,AVP,SPP1
GO:1904646	cellular response to amyloid-beta	3	39	1.35	ICAM1,IGF1,TLR4
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	8	518	0.65	TGFB1,HGF,IGF1,CTGF,NGF,INS,FGF21,VEGFA
GO:0042742	defense response to bacterium	6	277	0.8	MPO,CRP,IL6R,MBL2,TLR4,TNF
GO:0030516	regulation of axon extension	4	99	1.07	APOE,SEMA3A,WNT3A,VEGFA
GO:0034381	plasma lipoprotein particle clearance	3	40	1.34	APOE,APOA2,ADIPOQ
GO:0043065	positive regulation of apoptotic process	9	660	0.6	CCL2,PML,WNT3A,CTGF,NGF,CD40LG,ADIPOQ,TNF,TNFAIP8
GO:0043434	response to peptide hormone	7	394	0.72	LRP6,ICAM1,CTGF,EDN1,INS,ADIPOQ,FGF21
GO:0060191	regulation of lipase activity	4	99	1.07	ANGPTL4,APOA2,ANGPTL3,C19orf80
GO:0090184	positive regulation of kidney development	3	40	1.34	IL6R,ADIPOQ,VEGFA
GO:0042493	response to drug	6	281	0.79	TNFRSF11B,CYP2D6,APOA2,EDN1,ADIPOQ,FGF21
GO:0009395	phospholipid catabolic process	3	41	1.33	PLA2G7,APOA2,ANGPTL3
GO:0097190	apoptotic signaling pathway	6	286	0.79	TGFB1,PML,IL6R,NGF,TLR4,TNF
GO:0009611	response to wounding	8	532	0.64	TGFB1,KLKB1,WNT3A,CTGF,CD40LG,THBD,INS,VEGFA
GO:0010595	positive regulation of endothelial cell migration	4	103	1.05	TGFB1,EDN1,GPI,VEGFA
GO:0030308	negative regulation of cell growth	5	187	0.89	TGFB1,SEMA3A,PML,WNT3A,SPP1
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	2	8	1.86	IGF1,EDN1
GO:0072577	endothelial cell apoptotic process	2	8	1.86	TNF,FGF21
GO:0072683	T cell extravasation	2	8	1.86	CCL2,ICAM1
GO:0042593	glucose homeostasis	5	188	0.89	MTNR1B,ICAM1,INS,ADIPOQ,FGF21
GO:0071407	cellular response to organic cyclic compound	8	537	0.64	TGFB1,CCL2,LRP6,ICAM1,EDN1,SPP1,ADIPOQ,TNF
GO:0001937	negative regulation of endothelial cell proliferation	3	43	1.31	CCL2,APOE,TNF
GO:0010035	response to inorganic substance	8	538	0.64	MPO,FABP4,ICAM1,TNFRSF11B,HBA1,TXN,EDN1,SOD3
GO:1903522	regulation of blood circulation	6	292	0.78	ICAM1,SEMA3A,ACE,CTGF,EDN1,AVP
GO:2001233	regulation of apoptotic signaling pathway	7	409	0.7	HGF,ICAM1,PML,IGF1,AVP,INS,TNF
GO:0032091	negative regulation of protein binding	4	106	1.04	SORL1,ACE,DKK1,ADIPOQ
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	4	106	1.04	HGF,ICAM1,IGF1,TNF
GO:0044089	positive regulation of cellular component biogenesis	8	542	0.63	TGFB1,APOE,ICAM1,CTGF,TLR4,EDN1,TNF,VEGFA
GO:0051348	negative regulation of transferase activity	6	294	0.78	APOE,FABP4,SORL1,LRP6,PML,ADIPOQ
GO:0050679	positive regulation of epithelial cell proliferation	5	192	0.88	WNT3A,LRG1,IGF1,TLR4,VEGFA
GO:0001523	retinoid metabolic process	4	108	1.03	APOE,AKR1B10,CYP2D6,APOA2
GO:0044344	cellular response to fibroblast growth factor stimulus	4	108	1.03	CCL2,CXCL8,CTGF,FGF21
GO:0009790	embryo development	11	1002	0.51	TGFB1,LRP6,SEMA3A,WNT3A,CXCL8,MMP14,DKK1,EDN1,ITGB2,TNF,VEGFA
GO:0042445	hormone metabolic process	5	194	0.88	ACE,AKR1B10,CYP2D6,NGF,SPP1
GO:0008285	negative regulation of cell population proliferation	9	696	0.58	TGFB1,CCL2,APOE,CRP,PML,CXCL8,NGF,ADIPOQ,TNF
GO:0010873	positive regulation of cholesterol esterification	2	9	1.81	APOE,APOA2
GO:0034371	chylomicron remodeling	2	9	1.81	APOE,APOA2
GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process	2	9	1.81	ADIPOQ,FGF21
GO:0046890	regulation of lipid biosynthetic process	5	197	0.87	APOE,AVP,INS,ADIPOQ,TNF
GO:0048608	reproductive structure development	7	420	0.69	EPOR,LRP6,ICAM1,PTX3,MMP14,SPP1,VEGFA
GO:0060693	regulation of branching involved in salivary gland morphogenesis	2	9	1.81	HGF,TNF
GO:0090209	negative regulation of triglyceride metabolic process	2	9	1.81	APOE,SORL1
GO:0090381	regulation of heart induction	2	9	1.81	WNT3A,DKK1
GO:1902966	positive regulation of protein localization to early endosome	2	9	1.81	SORL1,VEGFA
GO:0002673	regulation of acute inflammatory response	3	47	1.27	KLKB1,INS,TNF
GO:1901654	response to ketone	5	199	0.87	TGFB1,ICAM1,EDN1,AVP,SPP1
GO:1903202	negative regulation of oxidative stress-induced cell death	3	47	1.27	HGF,TXN,INS
GO:0034762	regulation of transmembrane transport	8	560	0.62	CCL2,MTNR1B,IGF1,EDN1,INS,ADIPOQ,TNF,FGF21
GO:0006629	lipid metabolic process	12	1190	0.47	APOE,FABP4,PLA2G7,ANGPTL4,AKR1B10,CYP2D6,APOA2,ANGPTL3,EDN1,SPP1,ADIPOQ,C19orf80
GO:2000278	regulation of DNA biosynthetic process	4	114	1.01	HGF,PML,ADIPOQ,VEGFA
GO:0010749	regulation of nitric oxide mediated signal transduction	2	10	1.77	INS,VEGFA
GO:0034378	chylomicron assembly	2	10	1.77	APOE,APOA2
GO:0034384	high-density lipoprotein particle clearance	2	10	1.77	APOE,APOA2
GO:0035988	chondrocyte proliferation	2	10	1.77	MMP14,CTGF
GO:1901575	organic substance catabolic process	15	1750	0.4	TGFB1,APOE,CHI3L1,FABP4,PML,PLA2G7,ACE,AKR1B10,CYP2D6,APOA2,ANGPTL3,SPP1,ADIPOQ,GPI,ENO2
GO:1904338	regulation of dopaminergic neuron differentiation	2	10	1.77	WNT3A,DKK1
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	2	10	1.77	LRP6,WNT3A
GO:0001704	formation of primary germ layer	4	116	1	WNT3A,MMP14,DKK1,ITGB2
GO:0045667	regulation of osteoblast differentiation	4	117	1	HGF,IGF1,IL6R,TNF
GO:0007167	enzyme linked receptor protein signaling pathway	9	720	0.56	TGFB1,HGF,PML,IGF1,CTGF,NGF,INS,FGF21,VEGFA
GO:0009894	regulation of catabolic process	11	1038	0.49	HGF,APOE,SORL1,DESI1,PML,IGF1,APOA2,ANGPTL3,INS,TNF,FGF21
GO:0035094	response to nicotine	3	50	1.24	EDN1,AVP,TNF
GO:0009895	negative regulation of catabolic process	6	316	0.74	HGF,SORL1,PML,APOA2,INS,TNF
GO:0010906	regulation of glucose metabolic process	4	118	1	IGF1,C1QTNF3,INS,ADIPOQ
GO:0034764	positive regulation of transmembrane transport	5	208	0.85	CCL2,IGF1,INS,ADIPOQ,FGF21
GO:0042060	wound healing	7	439	0.67	TGFB1,KLKB1,WNT3A,CD40LG,THBD,INS,VEGFA
GO:0002703	regulation of leukocyte mediated immunity	5	209	0.84	TGFB1,ICAM1,TLR4,ITGB2,TNF
GO:0050830	defense response to Gram-positive bacterium	4	119	0.99	CRP,IL6R,MBL2,TNF
GO:0006909	phagocytosis	5	210	0.84	CRP,PTX3,MBL2,TLR4,ITGB2
GO:0008203	cholesterol metabolic process	4	120	0.99	APOE,CYP2D6,APOA2,ANGPTL3
GO:0001706	endoderm formation	3	52	1.23	MMP14,DKK1,ITGB2
GO:0001878	response to yeast	2	11	1.73	MPO,PTX3
GO:0002761	regulation of myeloid leukocyte differentiation	4	121	0.98	TGFB1,TLR4,ADIPOQ,TNF
GO:0009612	response to mechanical stimulus	5	212	0.84	MPO,CHI3L1,MMP14,TLR4,EDN1
GO:0032374	regulation of cholesterol transport	3	52	1.23	APOE,APOA2,ADIPOQ
GO:0042447	hormone catabolic process	2	11	1.73	ACE,SPP1
GO:0043523	regulation of neuron apoptotic process	5	212	0.84	CCL2,APOE,MTNR1B,NGF,TNF
GO:0090193	positive regulation of glomerulus development	2	11	1.73	IL6R,ADIPOQ
GO:0006066	alcohol metabolic process	6	324	0.73	APOE,IGF1,AKR1B10,CYP2D6,APOA2,ANGPTL3
GO:0002683	negative regulation of immune system process	7	450	0.66	TGFB1,CCL2,APOA2,TLR4,INS,ADIPOQ,TNF
GO:0042116	macrophage activation	3	53	1.22	TLR4,ITGB2,TNF
GO:0071417	cellular response to organonitrogen compound	8	590	0.6	ICAM1,IGF1,TLR4,EDN1,INS,ADIPOQ,TNF,FGF21
GO:0030301	cholesterol transport	3	54	1.21	APOE,LRP6,APOA2
GO:0002698	negative regulation of immune effector process	4	125	0.97	TGFB1,APOA2,INS,TNF
GO:0030879	mammary gland development	4	126	0.97	LRP6,PML,WNT3A,VEGFA
GO:0032944	regulation of mononuclear cell proliferation	5	220	0.82	CRP,WNT3A,IGF1,CD40LG,TLR4
GO:0033700	phospholipid efflux	2	12	1.69	APOE,APOA2
GO:0036499	PERK-mediated unfolded protein response	2	12	1.69	CCL2,CXCL8
GO:0048672	positive regulation of collateral sprouting	2	12	1.69	WNT3A,NGF
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	2	12	1.69	TLR4,TNF
GO:0046503	glycerolipid catabolic process	3	56	1.19	FABP4,PLA2G7,APOA2
GO:0060688	regulation of morphogenesis of a branching structure	3	56	1.19	HGF,TNF,VEGFA
GO:0002699	positive regulation of immune effector process	5	223	0.82	TGFB1,TLR4,ITGB2,TNF,GPI
GO:0055082	cellular chemical homeostasis	9	753	0.54	APOE,MTNR1B,LRP6,ICAM1,PML,EDN1,AVP,C1QTNF3,FGF21
GO:0051604	protein maturation	5	225	0.81	SORL1,KLKB1,ACE,MMP14,NGF
GO:0002024	diet induced thermogenesis	2	13	1.65	SORL1,UCP1
GO:0010745	negative regulation of macrophage derived foam cell differentiation	2	13	1.65	CRP,ADIPOQ
GO:0019430	removal of superoxide radicals	2	13	1.65	MPO,SOD3
GO:0034380	high-density lipoprotein particle assembly	2	13	1.65	APOE,APOA2
GO:0044793	negative regulation by host of viral process	2	13	1.65	CRP,PTX3
GO:0050680	negative regulation of epithelial cell proliferation	4	131	0.95	TGFB1,CCL2,APOE,TNF
GO:0002090	regulation of receptor internalization	3	58	1.18	WNT3A,DKK1,VEGFA
GO:0045840	positive regulation of mitotic nuclear division	3	58	1.18	IGF1,EDN1,INS
GO:0050922	negative regulation of chemotaxis	3	58	1.18	CCL2,SEMA3A,WNT3A
GO:0050807	regulation of synapse organization	5	228	0.81	APOE,WNT3A,DKK1,INS,TNF
GO:0046887	positive regulation of hormone secretion	4	132	0.95	EDN1,C1QTNF3,SPP1,INS
GO:0097755	positive regulation of blood vessel diameter	3	59	1.17	APOE,MTNR1B,INS
GO:1903793	positive regulation of anion transport	3	59	1.17	APOE,EDN1,AVP
GO:0050671	positive regulation of lymphocyte proliferation	4	134	0.94	WNT3A,IGF1,CD40LG,TLR4
GO:0015909	long-chain fatty acid transport	3	60	1.16	APOE,FABP4,ACE
GO:0032720	negative regulation of tumor necrosis factor production	3	60	1.16	IGF1,TLR4,ADIPOQ
GO:0035690	cellular response to drug	3	60	1.16	EDN1,ADIPOQ,FGF21
GO:0045669	positive regulation of osteoblast differentiation	3	60	1.16	HGF,IGF1,IL6R
GO:0097305	response to alcohol	5	233	0.8	TGFB1,LRP6,ICAM1,AVP,ADIPOQ
GO:0003084	positive regulation of systemic arterial blood pressure	2	14	1.62	ACE,AVP
GO:0010870	positive regulation of receptor biosynthetic process	2	14	1.62	EDN1,FGF21
GO:0010896	regulation of triglyceride catabolic process	2	14	1.62	SORL1,FGF21
GO:0032375	negative regulation of cholesterol transport	2	14	1.62	APOE,APOA2
GO:0044255	cellular lipid metabolic process	10	939	0.49	APOE,FABP4,PLA2G7,AKR1B10,CYP2D6,APOA2,ANGPTL3,EDN1,ADIPOQ,C19orf80
GO:0051917	regulation of fibrinolysis	2	14	1.62	KLKB1,THBD
GO:0055114	oxidation-reduction process	10	939	0.49	MPO,PLA2G7,AKR1B10,CYP2D6,APOA2,TXN,SOD3,ADIPOQ,GPI,ENO2
GO:0060429	epithelium development	11	1109	0.46	TGFB1,LRP6,ICAM1,SEMA3A,PML,WNT3A,MMP14,DKK1,EDN1,LAMA1,VEGFA
GO:0071901	negative regulation of protein serine/threonine kinase activity	4	136	0.93	APOE,SORL1,LRP6,ADIPOQ
GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	2	14	1.62	TGFB1,TNF
GO:0009620	response to fungus	3	61	1.16	MPO,PTX3,TLR4
GO:0048844	artery morphogenesis	3	61	1.16	APOE,ANGPTL3,VEGFA
GO:0055081	anion homeostasis	3	61	1.16	APOE,ANGPTL3,INS
GO:0006469	negative regulation of protein kinase activity	5	236	0.79	APOE,FABP4,SORL1,LRP6,ADIPOQ
GO:0043312	neutrophil degranulation	7	484	0.63	CEACAM6,MPO,CHI3L1,PTX3,LRG1,ITGB2,GPI
GO:0043436	oxoacid metabolic process	10	944	0.49	TGFB1,HGF,MPO,IGF1,CYP2D6,ANGPTL3,EDN1,ADIPOQ,GPI,ENO2
GO:0046888	negative regulation of hormone secretion	3	62	1.15	MTNR1B,EDN1,ADIPOQ
GO:0010638	positive regulation of organelle organization	8	633	0.57	ICAM1,PML,IGF1,CTGF,EDN1,INS,TNF,VEGFA
GO:0002449	lymphocyte mediated immunity	4	141	0.92	CRP,ICAM1,CD40LG,MBL2
GO:0010935	regulation of macrophage cytokine production	2	15	1.59	TGFB1,TLR4
GO:0015671	oxygen transport	2	15	1.59	NGB,HBA1
GO:0033043	regulation of organelle organization	12	1306	0.43	HGF,ICAM1,PML,WNT3A,IGF1,CTGF,EDN1,AVP,INS,TNF,ENO2,VEGFA
GO:0050930	induction of positive chemotaxis	2	15	1.59	CXCL8,VEGFA
GO:1903140	regulation of establishment of endothelial barrier	2	15	1.59	TNF,VEGFA
GO:0032507	maintenance of protein location in cell	3	64	1.14	SORL1,PML,TXN
GO:0031644	regulation of nervous system process	4	144	0.91	HGF,MTNR1B,EDN1,AVP
GO:0001756	somitogenesis	3	66	1.12	LRP6,WNT3A,DKK1
GO:0031349	positive regulation of defense response	6	367	0.68	FABP4,KLKB1,PLA2G7,TLR4,MUC16,TNF
GO:0034116	positive regulation of heterotypic cell-cell adhesion	2	16	1.56	CEACAM6,TNF
GO:0045725	positive regulation of glycogen biosynthetic process	2	16	1.56	IGF1,INS
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	2	16	1.56	APOE,TNF
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	2	16	1.56	CCL2,TLR4
GO:0051966	regulation of synaptic transmission, glutamatergic	3	66	1.12	CCL2,DKK1,TNF
GO:0055089	fatty acid homeostasis	2	16	1.56	APOE,INS
GO:0071637	regulation of monocyte chemotactic protein-1 production	2	16	1.56	C1QTNF3,ADIPOQ
GO:0006796	phosphate-containing compound metabolic process	16	2107	0.35	TGFB1,HGF,CCL2,PML,PLA2G7,IGF1,MOK,APOA2,CD40LG,ANGPTL3,TLR4,AVP,LAMA1,TNF,GPI,ENO2
GO:0007267	cell-cell signaling	11	1145	0.45	HGF,APOE,MTNR1B,LRP6,WNT3A,DKK1,EDN1,AVP,INS,ITGB2,FGF21
GO:0010557	positive regulation of macromolecule biosynthetic process	15	1906	0.36	TGFB1,HGF,CCL2,APOE,LRP6,PML,WNT3A,IGF1,TLR4,EDN1,SPP1,INS,TNF,FGF21,VEGFA
GO:0031334	positive regulation of protein-containing complex assembly	5	249	0.77	TGFB1,ICAM1,TLR4,TNF,VEGFA
GO:0098609	cell-cell adhesion	7	505	0.61	CEACAM6,LRP6,ICAM1,WNT3A,CD40LG,ITGB2,TNF
GO:0043524	negative regulation of neuron apoptotic process	4	148	0.9	CCL2,APOE,MTNR1B,NGF
GO:0044237	cellular metabolic process	38	7513	0.17	TGFB1,HGF,MPO,CCL2,APOE,FABP4,SORL1,DESI1,PML,PLA2G7,ACE,ALB,IGF1,CXCL8,NAGPA,HBA1,AKR1B10,CYP2D6,MOK,CTGF,APOA2,NGF,CD40LG,ANGPTL3,TLR4,EDN1,AVP,SOD3,LAMA1,SPP1,INS,ITGB2,MUC16,ADIPOQ,TNF,GPI,ENO2,C19orf80
GO:1902532	negative regulation of intracellular signal transduction	7	508	0.6	APOE,MTNR1B,SORL1,TLR4,C1QTNF3,INS,ADIPOQ
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	3	68	1.11	IGF1,IL6R,TNF
GO:0006641	triglyceride metabolic process	3	69	1.1	APOE,FABP4,APOA2
GO:0043691	reverse cholesterol transport	2	17	1.54	APOE,APOA2
GO:0046579	positive regulation of Ras protein signal transduction	3	69	1.1	EPOR,IGF1,NGF
GO:0060445	branching involved in salivary gland morphogenesis	2	17	1.54	SEMA3A,LAMA1
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	2	17	1.54	IGF1,TNF
GO:0090336	positive regulation of brown fat cell differentiation	2	17	1.54	FNDC5,INS
GO:1900221	regulation of amyloid-beta clearance	2	17	1.54	APOE,TNF
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	2	17	1.54	HGF,TXN
GO:0045666	positive regulation of neuron differentiation	6	377	0.67	HGF,APOE,WNT3A,NGF,DKK1,VEGFA
GO:0008202	steroid metabolic process	5	256	0.76	APOE,CYP2D6,APOA2,ANGPTL3,SPP1
GO:0032787	monocarboxylic acid metabolic process	7	515	0.6	IGF1,CYP2D6,ANGPTL3,EDN1,ADIPOQ,GPI,ENO2
GO:0001837	epithelial to mesenchymal transition	3	70	1.1	TGFB1,HGF,LRP6
GO:0050771	negative regulation of axonogenesis	3	70	1.1	SEMA3A,WNT3A,SPP1
GO:0008360	regulation of cell shape	4	153	0.88	CCL2,ICAM1,ITGB2,VEGFA
GO:1903900	regulation of viral life cycle	4	153	0.88	PML,PTX3,CXCL8,TNF
GO:0007548	sex differentiation	5	259	0.75	LRP6,ICAM1,PTX3,MMP14,VEGFA
GO:0050795	regulation of behavior	3	71	1.09	APOE,MTNR1B,INS
GO:0031065	positive regulation of histone deacetylation	2	18	1.51	PML,VEGFA
GO:0034249	negative regulation of cellular amide metabolic process	4	154	0.88	APOE,SORL1,PML,IGF1
GO:0043116	negative regulation of vascular permeability	2	18	1.51	APOE,VEGFA
GO:0050777	negative regulation of immune response	4	154	0.88	TGFB1,APOA2,INS,TNF
GO:0048699	generation of neurons	13	1551	0.39	TGFB1,HGF,APOE,SORL1,LRP6,SEMA3A,WNT3A,NGF,DKK1,LAMA1,SPP1,TNF,VEGFA
GO:0048863	stem cell differentiation	4	156	0.87	LRP6,SEMA3A,ACE,EDN1
GO:0007399	nervous system development	17	2371	0.32	TGFB1,EPOR,HGF,CCL2,APOE,SORL1,LRP6,SEMA3A,WNT3A,MMP14,NGF,DKK1,TLR4,LAMA1,SPP1,TNF,VEGFA
GO:0045787	positive regulation of cell cycle	6	388	0.65	LRP6,PML,IGF1,CTGF,EDN1,INS
GO:0048589	developmental growth	6	389	0.65	LRP6,SEMA3A,WNT3A,PTX3,IGF1,MBL2
GO:0001816	cytokine production	4	158	0.87	CHI3L1,FABP4,TLR4,TNF
GO:0016485	protein processing	4	158	0.87	KLKB1,ACE,MMP14,NGF
GO:0010544	negative regulation of platelet activation	2	19	1.49	APOE,THBD
GO:0030593	neutrophil chemotaxis	3	74	1.07	CCL2,CXCL8,ITGB2
GO:0031346	positive regulation of cell projection organization	6	391	0.65	HGF,APOE,WNT3A,NGF,INS,VEGFA
GO:0043627	response to estrogen	3	74	1.07	TNFRSF11B,MMP14,APOA2
GO:0071404	cellular response to low-density lipoprotein particle stimulus	2	19	1.49	ITGB2,FGF21
GO:0044238	primary metabolic process	37	7332	0.17	TGFB1,HGF,CCL2,APOE,CHI3L1,FABP4,SORL1,DESI1,KLKB1,PML,PLA2G7,ACE,ALB,ANGPTL4,IGF1,MMP14,NAGPA,AKR1B10,CYP2D6,MOK,CTGF,APOA2,NGF,CD40LG,ANGPTL3,TLR4,EDN1,AVP,LAMA1,SPP1,INS,MUC16,ADIPOQ,TNF,GPI,ENO2,C19orf80
GO:0033157	regulation of intracellular protein transport	5	268	0.74	TGFB1,SORL1,TXN,ITGB2,ADIPOQ
GO:0043407	negative regulation of MAP kinase activity	3	76	1.06	APOE,SORL1,ADIPOQ
GO:0006622	protein targeting to lysosome	2	20	1.47	SORL1,NAGPA
GO:0010875	positive regulation of cholesterol efflux	2	20	1.47	APOE,ADIPOQ
GO:0019752	carboxylic acid metabolic process	9	853	0.49	TGFB1,HGF,IGF1,CYP2D6,ANGPTL3,EDN1,ADIPOQ,GPI,ENO2
GO:0034142	toll-like receptor 4 signaling pathway	2	20	1.47	TLR4,ITGB2
GO:1900409	positive regulation of cellular response to oxidative stress	2	20	1.47	TLR4,TNF
GO:1902004	positive regulation of amyloid-beta formation	2	20	1.47	APOE,TNF
GO:2000353	positive regulation of endothelial cell apoptotic process	2	20	1.47	CCL2,CD40LG
GO:1901564	organonitrogen compound metabolic process	29	5244	0.21	TGFB1,HGF,CCL2,APOE,CHI3L1,SORL1,DESI1,KLKB1,PML,PLA2G7,ACE,ALB,IGF1,MMP14,NAGPA,CYP2D6,MOK,APOA2,NGF,CD40LG,TLR4,AVP,LAMA1,SPP1,INS,MUC16,TNF,GPI,ENO2
HSA-8963899	Plasma lipoprotein remodeling	7	32	1.81	APOE,ALB,ANGPTL4,APOA2,ANGPTL3,FGF21,C19orf80
HSA-6785807	Interleukin-4 and Interleukin-13 signaling	9	107	1.39	TGFB1,HGF,CCL2,ICAM1,CXCL8,IL6R,ITGB2,TNF,VEGFA
HSA-168256	Immune System	23	1956	0.54	CEACAM6,TGFB1,HGF,MPO,CCL2,CRP,CHI3L1,ICAM1,PML,PTX3,TNFRSF11B,LRG1,CXCL8,IL6R,CD40LG,MBL2,TLR4,TXN,ITGB2,MUC16,TNF,GPI,VEGFA
HSA-8963889	Assembly of active LPL and LIPC lipase complexes	4	19	1.79	ANGPTL4,ANGPTL3,FGF21,C19orf80
HSA-1280215	Cytokine Signaling in Immune system	12	681	0.71	TGFB1,HGF,CCL2,ICAM1,PML,TNFRSF11B,CXCL8,IL6R,CD40LG,ITGB2,TNF,VEGFA
HSA-162582	Signal Transduction	24	2741	0.41	TGFB1,EPOR,HGF,CCL2,APOE,MTNR1B,LRP6,PML,WNT3A,IGF1,CXCL8,AKR1B10,APOA2,IL6R,NGF,ANGPTL3,DKK1,EDN1,AVP,LAMA1,SPP1,INS,TNF,VEGFA
HSA-1474244	Extracellular matrix organization	8	301	0.89	CEACAM6,TGFB1,KLKB1,ICAM1,MMP14,LAMA1,SPP1,ITGB2
HSA-381340	Transcriptional regulation of white adipocyte differentiation	5	84	1.24	TGFB1,FABP4,ANGPTL4,ADIPOQ,TNF
HSA-6783783	Interleukin-10 signaling	4	45	1.41	CCL2,ICAM1,CXCL8,TNF
HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	3	15	1.77	LRP6,WNT3A,DKK1
HSA-382551	Transport of small molecules	11	721	0.65	APOE,LCN9,ALB,NGB,ANGPTL4,HBA1,APOA2,ANGPTL3,AVP,FGF21,C19orf80