109 biomarker pathways
| Pathway ID | Term Description | Observed Gene Count | Background Gene Count | Strength | Biomarkers |
|---|---|---|---|---|---|
| GO:0016209 | antioxidant activity | 3 | 74 | 1.86 | CAT,SOD1,GPX1 |
| hsa04213 | Longevity regulating pathway - multiple species | 3 | 61 | 1.94 | SIRT1,CAT,SOD1 |
| GO:0060548 | negative regulation of cell death | 8 | 999 | 1.15 | CEACAM6,SIRT1,CAT,SOD1,CTGF,RGN,GPX1,VEGFA |
| GO:0003018 | vascular process in circulatory system | 5 | 185 | 1.68 | CRP,SOD1,ACE,GPX1,VEGFA |
| GO:0007568 | aging | 5 | 274 | 1.51 | SIRT1,CAT,SOD1,CTGF,RGN |
| GO:0042127 | regulation of cell population proliferation | 8 | 1642 | 0.94 | CEACAM6,SIRT1,CRP,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:0042542 | response to hydrogen peroxide | 4 | 119 | 1.78 | SIRT1,CAT,SOD1,GPX1 |
| GO:0042981 | regulation of apoptotic process | 8 | 1550 | 0.96 | CEACAM6,SIRT1,CAT,SOD1,CTGF,RGN,GPX1,VEGFA |
| GO:0043066 | negative regulation of apoptotic process | 7 | 893 | 1.14 | CEACAM6,SIRT1,CAT,SOD1,RGN,GPX1,VEGFA |
| GO:0046903 | secretion | 7 | 1097 | 1.06 | CEACAM6,CAT,SOD1,ACE,SLPI,CTGF,VEGFA |
| GO:0048523 | negative regulation of cellular process | 11 | 4874 | 0.6 | CEACAM6,SIRT1,CAT,CRP,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0072593 | reactive oxygen species metabolic process | 4 | 112 | 1.8 | CAT,SOD1,CTGF,GPX1 |
| GO:1900407 | regulation of cellular response to oxidative stress | 4 | 81 | 1.94 | SIRT1,SOD1,RGN,GPX1 |
| GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 3 | 27 | 2.3 | SIRT1,SOD1,GPX1 |
| GO:0044092 | negative regulation of molecular function | 7 | 1163 | 1.03 | SIRT1,CAT,ACE,SLPI,RGN,GPX1,VEGFA |
| GO:0097746 | regulation of blood vessel diameter | 4 | 139 | 1.71 | CRP,SOD1,ACE,GPX1 |
| GO:0030162 | regulation of proteolysis | 6 | 747 | 1.15 | SIRT1,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0080135 | regulation of cellular response to stress | 6 | 739 | 1.16 | SIRT1,SOD1,CTGF,RGN,GPX1,VEGFA |
| GO:0090322 | regulation of superoxide metabolic process | 3 | 36 | 2.17 | CRP,SOD1,RGN |
| GO:0008015 | blood circulation | 5 | 394 | 1.35 | CRP,SOD1,ACE,GPX1,VEGFA |
| GO:0042743 | hydrogen peroxide metabolic process | 3 | 39 | 2.14 | CAT,SOD1,GPX1 |
| GO:0051336 | regulation of hydrolase activity | 7 | 1284 | 0.99 | SIRT1,SOD1,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0052548 | regulation of endopeptidase activity | 5 | 418 | 1.33 | SIRT1,SLPI,CTGF,GPX1,VEGFA |
| GO:0051346 | negative regulation of hydrolase activity | 5 | 450 | 1.3 | SIRT1,SLPI,RGN,GPX1,VEGFA |
| GO:0048584 | positive regulation of response to stimulus | 8 | 2257 | 0.8 | SIRT1,CAT,CRP,SOD1,CTGF,RGN,GPX1,VEGFA |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 4 | 216 | 1.52 | SIRT1,CTGF,GPX1,VEGFA |
| GO:0090066 | regulation of anatomical structure size | 5 | 516 | 1.24 | CRP,SOD1,ACE,GPX1,VEGFA |
| GO:0032940 | secretion by cell | 6 | 979 | 1.04 | CEACAM6,CAT,SOD1,SLPI,CTGF,VEGFA |
| GO:0050790 | regulation of catalytic activity | 8 | 2386 | 0.78 | SIRT1,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation | 2 | 5 | 2.85 | ACE,VEGFA |
| GO:0002376 | immune system process | 8 | 2481 | 0.76 | CEACAM6,SIRT1,CAT,CRP,SOD1,ACE,SLPI,VEGFA |
| GO:0006641 | triglyceride metabolic process | 3 | 69 | 1.89 | SIRT1,CAT,GPX1 |
| GO:0034599 | cellular response to oxidative stress | 4 | 244 | 1.46 | SIRT1,CAT,SOD1,GPX1 |
| GO:1902533 | positive regulation of intracellular signal transduction | 6 | 1041 | 1.01 | SIRT1,CAT,SOD1,CTGF,GPX1,VEGFA |
| GO:0001822 | kidney development | 4 | 271 | 1.42 | CAT,ACE,RGN,VEGFA |
| GO:0050793 | regulation of developmental process | 8 | 2648 | 0.73 | SIRT1,CRP,SOD1,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:1902531 | regulation of intracellular signal transduction | 7 | 1807 | 0.84 | SIRT1,CAT,SOD1,CTGF,RGN,GPX1,VEGFA |
| GO:0002443 | leukocyte mediated immunity | 5 | 641 | 1.14 | CEACAM6,CAT,CRP,ACE,SLPI |
| GO:0008585 | female gonad development | 3 | 91 | 1.77 | SIRT1,SOD1,VEGFA |
| GO:0009628 | response to abiotic stimulus | 6 | 1147 | 0.97 | SIRT1,CAT,SOD1,CTGF,GPX1,VEGFA |
| GO:0032268 | regulation of cellular protein metabolic process | 8 | 2693 | 0.72 | SIRT1,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0044093 | positive regulation of molecular function | 7 | 1842 | 0.83 | SIRT1,CAT,SOD1,ACE,CTGF,RGN,VEGFA |
| GO:0045937 | positive regulation of phosphate metabolic process | 6 | 1164 | 0.96 | SIRT1,SOD1,ACE,CTGF,RGN,VEGFA |
| GO:0060047 | heart contraction | 3 | 88 | 1.78 | SOD1,ACE,GPX1 |
| GO:0001525 | angiogenesis | 4 | 315 | 1.35 | SIRT1,CTGF,GPX1,VEGFA |
| GO:0045055 | regulated exocytosis | 5 | 697 | 1.11 | CEACAM6,CAT,SOD1,SLPI,VEGFA |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 3 | 103 | 1.71 | CRP,SOD1,RGN |
| GO:0050678 | regulation of epithelial cell proliferation | 4 | 339 | 1.32 | SIRT1,RGN,GPX1,VEGFA |
| GO:0009650 | UV protection | 2 | 13 | 2.44 | CAT,GPX1 |
| GO:0048522 | positive regulation of cellular process | 10 | 5579 | 0.5 | CEACAM6,SIRT1,CAT,CRP,SOD1,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:0048871 | multicellular organismal homeostasis | 4 | 352 | 1.31 | SOD1,CTGF,GPX1,VEGFA |
| GO:0036293 | response to decreased oxygen levels | 4 | 354 | 1.3 | SIRT1,CAT,CTGF,VEGFA |
| GO:2000026 | regulation of multicellular organismal development | 7 | 2096 | 0.77 | SIRT1,SOD1,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:0009892 | negative regulation of metabolic process | 8 | 3124 | 0.66 | SIRT1,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0045859 | regulation of protein kinase activity | 5 | 812 | 1.04 | SIRT1,SOD1,ACE,RGN,VEGFA |
| GO:0060055 | angiogenesis involved in wound healing | 2 | 17 | 2.32 | GPX1,VEGFA |
| GO:0048513 | animal organ development | 8 | 3197 | 0.65 | SIRT1,CAT,SOD1,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:0032780 | negative regulation of ATPase activity | 2 | 18 | 2.3 | SIRT1,RGN |
| GO:0051239 | regulation of multicellular organismal process | 8 | 3227 | 0.64 | SIRT1,CRP,SOD1,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:0001932 | regulation of protein phosphorylation | 6 | 1459 | 0.86 | SIRT1,SOD1,ACE,CTGF,RGN,VEGFA |
| GO:0035295 | tube development | 5 | 851 | 1.02 | SIRT1,CAT,CTGF,GPX1,VEGFA |
| GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 2 | 19 | 2.27 | SIRT1,GPX1 |
| GO:0009411 | response to UV | 3 | 144 | 1.57 | SIRT1,CAT,GPX1 |
| GO:0032930 | positive regulation of superoxide anion generation | 2 | 20 | 2.25 | CRP,SOD1 |
| GO:0043085 | positive regulation of catalytic activity | 6 | 1489 | 0.86 | SIRT1,SOD1,ACE,CTGF,RGN,VEGFA |
| GO:1900409 | positive regulation of cellular response to oxidative stress | 2 | 20 | 2.25 | SOD1,RGN |
| GO:0002682 | regulation of immune system process | 6 | 1514 | 0.85 | SIRT1,CRP,SOD1,ACE,GPX1,VEGFA |
| GO:0031323 | regulation of cellular metabolic process | 10 | 6239 | 0.45 | SIRT1,CAT,CRP,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:1901700 | response to oxygen-containing compound | 6 | 1567 | 0.83 | SIRT1,CAT,SOD1,SLPI,CTGF,GPX1 |
| GO:2000145 | regulation of cell motility | 5 | 929 | 0.98 | CEACAM6,SIRT1,ACE,RGN,VEGFA |
| GO:0003006 | developmental process involved in reproduction | 5 | 945 | 0.97 | SIRT1,SOD1,ACE,RGN,VEGFA |
| GO:0006950 | response to stress | 8 | 3485 | 0.61 | SIRT1,CAT,CRP,SOD1,SLPI,CTGF,GPX1,VEGFA |
| GO:0030225 | macrophage differentiation | 2 | 26 | 2.14 | SIRT1,VEGFA |
| GO:0032270 | positive regulation of cellular protein metabolic process | 6 | 1635 | 0.81 | SIRT1,SOD1,ACE,CTGF,RGN,VEGFA |
| GO:0060255 | regulation of macromolecule metabolic process | 10 | 6407 | 0.44 | SIRT1,CAT,CRP,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0002446 | neutrophil mediated immunity | 4 | 495 | 1.16 | CEACAM6,CAT,ACE,SLPI |
| GO:0071363 | cellular response to growth factor stimulus | 4 | 494 | 1.16 | SIRT1,CAT,CTGF,VEGFA |
| GO:0042592 | homeostatic process | 6 | 1676 | 0.8 | SIRT1,SOD1,CTGF,RGN,GPX1,VEGFA |
| GO:0042744 | hydrogen peroxide catabolic process | 2 | 28 | 2.1 | CAT,GPX1 |
| GO:0065009 | regulation of molecular function | 9 | 4913 | 0.51 | SIRT1,CAT,SOD1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0001934 | positive regulation of protein phosphorylation | 5 | 1019 | 0.94 | SIRT1,SOD1,ACE,CTGF,VEGFA |
| GO:0007283 | spermatogenesis | 4 | 525 | 1.13 | SIRT1,SOD1,ACE,RGN |
| GO:0032269 | negative regulation of cellular protein metabolic process | 5 | 1043 | 0.93 | SIRT1,SLPI,RGN,GPX1,VEGFA |
| GO:0043534 | blood vessel endothelial cell migration | 2 | 31 | 2.06 | GPX1,VEGFA |
| GO:0009611 | response to wounding | 4 | 532 | 1.13 | SOD1,CTGF,GPX1,VEGFA |
| GO:0046890 | regulation of lipid biosynthetic process | 3 | 197 | 1.43 | SIRT1,SOD1,RGN |
| GO:0042311 | vasodilation | 2 | 33 | 2.03 | SOD1,GPX1 |
| GO:0045860 | positive regulation of protein kinase activity | 4 | 550 | 1.11 | SIRT1,SOD1,ACE,VEGFA |
| GO:0016192 | vesicle-mediated transport | 6 | 1805 | 0.77 | CEACAM6,CAT,CRP,SOD1,SLPI,VEGFA |
| GO:0032879 | regulation of localization | 7 | 2740 | 0.66 | CEACAM6,SIRT1,CRP,SOD1,ACE,RGN,VEGFA |
| GO:0001894 | tissue homeostasis | 3 | 219 | 1.39 | SOD1,CTGF,VEGFA |
| GO:0010907 | positive regulation of glucose metabolic process | 2 | 38 | 1.97 | SIRT1,RGN |
| GO:0048534 | hematopoietic or lymphoid organ development | 4 | 619 | 1.06 | SIRT1,SOD1,ACE,VEGFA |
| GO:0010605 | negative regulation of macromolecule metabolic process | 7 | 2875 | 0.64 | SIRT1,ACE,SLPI,CTGF,RGN,GPX1,VEGFA |
| GO:0065008 | regulation of biological quality | 8 | 4042 | 0.55 | SIRT1,CRP,SOD1,ACE,CTGF,RGN,GPX1,VEGFA |
| GO:0010951 | negative regulation of endopeptidase activity | 3 | 248 | 1.33 | SLPI,GPX1,VEGFA |
| GO:0042304 | regulation of fatty acid biosynthetic process | 2 | 47 | 1.88 | SIRT1,RGN |
| GO:0006749 | glutathione metabolic process | 2 | 49 | 1.86 | SOD1,GPX1 |
| GO:0010883 | regulation of lipid storage | 2 | 50 | 1.85 | SIRT1,CRP |
| GO:0051055 | negative regulation of lipid biosynthetic process | 2 | 51 | 1.84 | SIRT1,SOD1 |
| GO:0051179 | localization | 9 | 5591 | 0.46 | CEACAM6,CAT,CRP,SOD1,ACE,SLPI,CTGF,GPX1,VEGFA |
| GO:0001541 | ovarian follicle development | 2 | 53 | 1.83 | SOD1,VEGFA |
| GO:0048747 | muscle fiber development | 2 | 54 | 1.82 | GPX1,VEGFA |
| GO:0001954 | positive regulation of cell-matrix adhesion | 2 | 55 | 1.81 | CEACAM6,VEGFA |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | 2 | 56 | 1.8 | SIRT1,VEGFA |
| GO:0051129 | negative regulation of cellular component organization | 4 | 713 | 1 | SIRT1,ACE,GPX1,VEGFA |
| GO:0006810 | transport | 8 | 4353 | 0.51 | CEACAM6,CAT,CRP,SOD1,ACE,SLPI,CTGF,VEGFA |
| GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 2 | 60 | 1.77 | SIRT1,SOD1 |
| HSA-3299685 | Detoxification of Reactive Oxygen Species | 3 | 37 | 2.16 | CAT,SOD1,GPX1 |