377 biomarker pathways
| Pathway ID | Term Description | Observed Gene Count | Background Gene Count | Strength | Biomarkers |
|---|---|---|---|---|---|
| GO:0005576 | extracellular region | 37 | 4166 | 0.48 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,CHI3L1,ABCB6,CDH2,SOD1,THY1,ALB,CLU,LILRB1,FBLN7,SELE,BSG,MAPT,APOD,EPHB4,PGAM1,PTGDS,MMP9,SPTAN1,EPHA10,NPPA,CST3,GSTP1,TF,CD44,BDNF,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0005615 | extracellular space | 32 | 3195 | 0.54 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,CHI3L1,ABCB6,SOD1,THY1,ALB,CLU,SELE,BSG,APOD,EPHB4,PGAM1,PTGDS,MMP9,SPTAN1,NPPA,CST3,GSTP1,TF,CD44,BDNF,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0030141 | secretory granule | 18 | 845 | 0.86 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,ALB,CLU,BSG,PGAM1,MMP9,VDAC2,SPTAN1,CST3,GSTP1,TF,CD44,BDNF,VEGFA |
| GO:0031982 | vesicle | 33 | 3879 | 0.47 | MYOC,PSMA4,CEACAM6,TGFB1,TTR,GDF15,TRIM21,CHI3L1,ABCB6,SOD1,THY1,ALB,NOS3,CLU,NOS2,BSG,APOD,HTT,EPHB4,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,OPTN,CST3,GSTP1,TF,CD44,BDNF,NUCB2,ENO2,VEGFA |
| GO:0070062 | extracellular exosome | 23 | 2099 | 0.58 | MYOC,PSMA4,TTR,GDF15,CHI3L1,ABCB6,SOD1,THY1,ALB,CLU,BSG,APOD,EPHB4,PGAM1,PTGDS,MMP9,SPTAN1,CST3,GSTP1,TF,CD44,NUCB2,ENO2 |
| GO:0031410 | cytoplasmic vesicle | 24 | 2386 | 0.54 | MYOC,CEACAM6,TGFB1,TTR,TRIM21,CHI3L1,ABCB6,SOD1,ALB,NOS3,CLU,BSG,HTT,PGAM1,MMP9,VDAC2,SPTAN1,OPTN,CST3,GSTP1,TF,CD44,BDNF,VEGFA |
| GO:0012505 | endomembrane system | 33 | 4542 | 0.4 | MYOC,CEACAM6,TGFB1,TTR,GDF15,CHI3L1,ABCB6,CDH2,SOD1,THY1,DUSP2,ALB,NOS3,CLU,SELE,BSG,APOD,HTT,PLA2G4A,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,OPTN,CST3,GSTP1,TF,CD44,BDNF,MLIP,NUCB2,VEGFA |
| GO:0034774 | secretory granule lumen | 10 | 324 | 1.03 | TGFB1,TTR,CHI3L1,ALB,CLU,PGAM1,SPTAN1,GSTP1,TF,VEGFA |
| GO:0048471 | perinuclear region of cytoplasm | 13 | 727 | 0.79 | CHI3L1,AIFM1,CLU,NOS2,SELE,APOD,HTT,PTGDS,NPPA,OPTN,CST3,TF,BDNF |
| GO:0005737 | cytoplasm | 49 | 11428 | 0.17 | MYOC,PSMA4,CEACAM6,TGFB1,TTR,GDF15,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,BTG3,APOD,HTT,EPHB4,CALD1,PLA2G4A,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,NAIF1,NPPA,HSPA14,OPTN,PC,CST3,GSTP1,TF,CASP14,CD44,BDNF,NUCB2,ENO2,CCL5,VEGFA |
| GO:0031012 | extracellular matrix | 9 | 527 | 0.77 | MYOC,TGFB1,CHI3L1,CDH2,CLU,MMP9,NPPA,CST3,VEGFA |
| GO:0036477 | somatodendritic compartment | 11 | 852 | 0.65 | SOD1,THY1,CLU,MAPT,APOD,HTT,NPPA,MBP,CST3,BDNF,ENO2 |
| GO:0005794 | Golgi apparatus | 15 | 1584 | 0.51 | MYOC,TGFB1,GDF15,ABCB6,ALB,NOS3,CLU,BSG,HTT,PLA2G4A,PTGDS,OPTN,CST3,CD44,NUCB2 |
| GO:0070013 | intracellular organelle lumen | 32 | 5857 | 0.27 | MYOC,PSMA4,TGFB1,TTR,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,AIFM1,DUSP2,ALB,CLU,NOS2,MAPT,HTT,PGAM1,MMP9,VDAC2,SPTAN1,NAIF1,OPTN,PC,CST3,GSTP1,TF,CASP14,MYOCD,BDNF,MLIP,VEGFA |
| GO:0045121 | membrane raft | 7 | 324 | 0.87 | CDH2,THY1,NOS3,SELE,BSG,MAPT,VDAC2 |
| GO:0005783 | endoplasmic reticulum | 14 | 1438 | 0.52 | MYOC,CHI3L1,ABCB6,CDH2,THY1,ALB,CLU,APOD,HTT,PLA2G4A,PTGDS,CST3,TF,NUCB2 |
| GO:0031093 | platelet alpha granule lumen | 4 | 68 | 1.31 | TGFB1,ALB,CLU,VEGFA |
| GO:0044304 | main axon | 4 | 70 | 1.29 | MYOC,THY1,MAPT,MBP |
| GO:0030424 | axon | 9 | 646 | 0.68 | MYOC,SOD1,THY1,BSG,MAPT,HTT,MBP,CST3,BDNF |
| GO:0009986 | cell surface | 10 | 824 | 0.62 | CEACAM6,TGFB1,CDH2,THY1,CLU,LILRB1,MBP,TF,CD44,VEGFA |
| GO:0043005 | neuron projection | 13 | 1366 | 0.51 | MYOC,CDH2,SOD1,THY1,CLU,BSG,MAPT,APOD,HTT,EPHA10,MBP,CST3,BDNF |
| GO:0043025 | neuronal cell body | 8 | 518 | 0.72 | SOD1,THY1,MAPT,APOD,NPPA,MBP,CST3,ENO2 |
| GO:0062023 | collagen-containing extracellular matrix | 7 | 396 | 0.78 | MYOC,TGFB1,CDH2,CLU,MMP9,NPPA,CST3 |
| GO:0005739 | mitochondrion | 14 | 1611 | 0.47 | MYOC,ABCB6,SOD1,AIFM1,CLU,BSG,MAPT,PLA2G4A,VDAC2,NAIF1,PC,GSTP1,CASP14,BDNF |
| GO:0031967 | organelle envelope | 12 | 1213 | 0.53 | MYOC,ABCB6,SOD1,AIFM1,DUSP2,CLU,PLA2G4A,PTGDS,VDAC2,CST3,MLIP,NUCB2 |
| GO:0097418 | neurofibrillary tangle | 2 | 5 | 2.14 | CLU,MAPT |
| GO:0030863 | cortical cytoskeleton | 4 | 96 | 1.16 | NOS2,SELE,CALD1,SPTAN1 |
| GO:0098805 | whole membrane | 14 | 1715 | 0.45 | MYOC,CEACAM6,ABCB6,CDH2,THY1,NOS3,SELE,BSG,MAPT,VDAC2,OPTN,TF,CD44,NUCB2 |
| GO:0072562 | blood microparticle | 4 | 115 | 1.08 | TGFB1,ALB,CLU,TF |
| GO:0005773 | vacuole | 9 | 792 | 0.59 | CEACAM6,TTR,TRIM21,ABCB6,SOD1,HTT,NPPA,OPTN,CST3 |
| GO:1904813 | ficolin-1-rich granule lumen | 4 | 125 | 1.04 | PGAM1,MMP9,CST3,GSTP1 |
| GO:0005622 | intracellular | 52 | 14276 | 0.1 | MYOC,PSMA4,CEACAM6,TGFB1,TTR,GDF15,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,BTG3,APOD,HTT,EPHB4,CALD1,PLA2G4A,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,NAIF1,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,CASP14,CD44,MYOCD,BDNF,MLIP,NUCB2,ENO2,CCL5,VEGFA |
| GO:0005829 | cytosol | 27 | 5193 | 0.25 | PSMA4,TRIM21,ABCB6,SOD1,EIF2D,THY1,AIFM1,NOS3,CLU,NOS2,MAPT,APOD,HTT,EPHB4,CALD1,PLA2G4A,PGAM1,SPTAN1,NAIF1,HSPA14,OPTN,PC,GSTP1,CASP14,CD44,NUCB2,ENO2 |
| GO:1904724 | tertiary granule lumen | 3 | 55 | 1.27 | MMP9,SPTAN1,CST3 |
| GO:0005515 | protein binding | 40 | 7026 | 0.29 | MYOC,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CDH2,SOD1,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,HTT,CALD1,PGAM1,MMP9,SPTAN1,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,MYOCD,BDNF,MLIP,NUCB2,PGF,CCL5,VEGFA |
| GO:0031406 | carboxylic acid binding | 8 | 218 | 1.1 | ALB,NOS3,NOS2,SELE,PTGDS,PC,GSTP1,CD44 |
| GO:0042802 | identical protein binding | 19 | 1896 | 0.54 | CEACAM6,TGFB1,TTR,GDF15,TRIM21,CDH2,SOD1,ALB,LILRB1,NOS2,MAPT,HTT,MMP9,OPTN,PC,CST3,PGF,CCL5,VEGFA |
| GO:0005488 | binding | 52 | 12516 | 0.15 | MYOC,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,FBLN7,SELE,BSG,MAPT,APOD,HTT,EPHB4,CALD1,PLA2G4A,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,EPHA10,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0019899 | enzyme binding | 19 | 2239 | 0.46 | MYOC,TGFB1,TRIM21,CDH2,SOD1,THY1,DUSP2,CLU,LILRB1,SELE,MAPT,HTT,PGAM1,OPTN,MBP,CST3,GSTP1,MYOCD,NUCB2 |
| GO:0048018 | receptor ligand activity | 9 | 490 | 0.8 | CCL22,TGFB1,TTR,GDF15,NPPA,BDNF,PGF,CCL5,VEGFA |
| GO:0033293 | monocarboxylic acid binding | 4 | 73 | 1.27 | ALB,PTGDS,PC,GSTP1 |
| GO:0004517 | nitric-oxide synthase activity | 2 | 3 | 2.36 | NOS3,NOS2 |
| hsa04066 | HIF-1 signaling pathway | 6 | 106 | 1.29 | NOS3,NOS2,NPPA,TF,ENO2,VEGFA |
| hsa04010 | MAPK signaling pathway | 7 | 288 | 0.92 | TGFB1,DUSP2,MAPT,PLA2G4A,BDNF,PGF,VEGFA |
| hsa04926 | Relaxin signaling pathway | 5 | 128 | 1.13 | TGFB1,NOS3,NOS2,MMP9,VEGFA |
| hsa05418 | Fluid shear stress and atherosclerosis | 5 | 130 | 1.12 | NOS3,SELE,MMP9,GSTP1,VEGFA |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 4 | 98 | 1.15 | TGFB1,NOS3,SELE,VEGFA |
| GO:0019220 | regulation of phosphate metabolic process | 27 | 1816 | 0.71 | MYOC,CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,NOS2,MAPT,HTT,EPHB4,PGAM1,MMP9,EPHA10,NPPA,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0042325 | regulation of phosphorylation | 25 | 1626 | 0.72 | MYOC,CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,THY1,DUSP2,CLU,MAPT,HTT,EPHB4,PGAM1,MMP9,EPHA10,NPPA,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0009605 | response to external stimulus | 28 | 2310 | 0.62 | CCL22,TGFB1,GDF15,TRIM21,CHI3L1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,HTT,SPTAN1,EPHA10,NPPA,OPTN,CST3,GSTP1,TF,CD44,MYOCD,BDNF,NUCB2,PGF,CCL5,VEGFA |
| GO:0048585 | negative regulation of response to stimulus | 24 | 1636 | 0.7 | MYOC,PSMA4,TGFB1,GDF15,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,LILRB1,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,CD44,MYOCD,BDNF,MLIP,NUCB2,CCL5 |
| GO:0050790 | regulation of catalytic activity | 28 | 2386 | 0.61 | CCL22,TGFB1,GDF15,CHI3L1,SOD1,THY1,AIFM1,DUSP2,NOS3,CLU,NOS2,SELE,MAPT,HTT,EPHB4,ADORA3,MMP9,EPHA10,NPPA,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0043549 | regulation of kinase activity | 18 | 918 | 0.83 | TGFB1,GDF15,CHI3L1,SOD1,THY1,DUSP2,CLU,MAPT,HTT,EPHB4,EPHA10,NPPA,GSTP1,TF,MYOCD,BDNF,CCL5,VEGFA |
| GO:0044093 | positive regulation of molecular function | 24 | 1842 | 0.65 | CCL22,TGFB1,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,NOS3,CLU,NOS2,SELE,MAPT,HTT,EPHB4,MMP9,EPHA10,NPPA,MBP,TF,MYOCD,BDNF,CCL5,VEGFA |
| GO:0051246 | regulation of protein metabolic process | 29 | 2828 | 0.55 | MYOC,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,CLU,NOS2,MAPT,APOD,HTT,MMP9,NPPA,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0010648 | negative regulation of cell communication | 21 | 1382 | 0.72 | MYOC,PSMA4,TGFB1,GDF15,CDH2,THY1,DUSP2,NOS3,CLU,LILRB1,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,CD44,MYOCD,BDNF,CCL5 |
| GO:0023057 | negative regulation of signaling | 21 | 1385 | 0.72 | MYOC,PSMA4,TGFB1,GDF15,CDH2,THY1,DUSP2,NOS3,CLU,LILRB1,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,CD44,MYOCD,BDNF,CCL5 |
| GO:0046903 | secretion | 19 | 1097 | 0.77 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,ALB,CLU,NOS2,PLA2G4A,PGAM1,MMP9,SPTAN1,CST3,GSTP1,TF,CD44,BDNF,CCL5,VEGFA |
| GO:0032940 | secretion by cell | 18 | 979 | 0.8 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,ALB,CLU,NOS2,PGAM1,MMP9,SPTAN1,CST3,GSTP1,TF,CD44,BDNF,CCL5,VEGFA |
| GO:0009968 | negative regulation of signal transduction | 20 | 1271 | 0.73 | MYOC,PSMA4,TGFB1,GDF15,CDH2,THY1,DUSP2,NOS3,CLU,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,CD44,MYOCD,BDNF,CCL5 |
| GO:0048583 | regulation of response to stimulus | 34 | 4114 | 0.45 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,APOD,HTT,PLA2G4A,MMP9,VDAC2,NPPA,OPTN,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,NUCB2,PGF,CCL5,VEGFA |
| GO:0001932 | regulation of protein phosphorylation | 21 | 1459 | 0.69 | MYOC,CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,THY1,DUSP2,CLU,HTT,MMP9,NPPA,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0045937 | positive regulation of phosphate metabolic process | 19 | 1164 | 0.75 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,NOS3,CLU,NOS2,MAPT,EPHB4,MMP9,EPHA10,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0006887 | exocytosis | 16 | 789 | 0.84 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,ALB,CLU,PGAM1,MMP9,SPTAN1,CST3,GSTP1,TF,CD44,CCL5,VEGFA |
| GO:0031399 | regulation of protein modification process | 23 | 1870 | 0.63 | MYOC,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,DUSP2,CLU,MAPT,HTT,MMP9,NPPA,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0048584 | positive regulation of response to stimulus | 25 | 2257 | 0.58 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,NOS3,CLU,LILRB1,HTT,PLA2G4A,MMP9,NPPA,OPTN,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0002376 | immune system process | 26 | 2481 | 0.56 | PSMA4,CEACAM6,CCL22,TGFB1,TTR,TRIM21,CHI3L1,SOD1,THY1,CLU,LILRB1,NOS2,SELE,BSG,MAPT,PGAM1,MMP9,SPTAN1,OPTN,MBP,CST3,GSTP1,TF,CD44,CCL5,VEGFA |
| GO:0032268 | regulation of cellular protein metabolic process | 27 | 2693 | 0.54 | MYOC,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,CLU,MAPT,HTT,MMP9,NPPA,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0045055 | regulated exocytosis | 15 | 697 | 0.87 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,ALB,CLU,PGAM1,MMP9,SPTAN1,CST3,GSTP1,TF,CD44,VEGFA |
| GO:0031325 | positive regulation of cellular metabolic process | 30 | 3413 | 0.48 | CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,HTT,EPHB4,MMP9,EPHA10,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0051239 | regulation of multicellular organismal process | 29 | 3227 | 0.49 | PSMA4,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,NOS3,CLU,LILRB1,NOS2,BSG,MAPT,APOD,PLA2G4A,ADORA3,PTGDS,MMP9,NPPA,MBP,CST3,GSTP1,TF,MYOCD,BDNF,MLIP,PGF,VEGFA |
| GO:0051716 | cellular response to stimulus | 41 | 6489 | 0.34 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,APOD,EPHB4,PLA2G4A,ADORA3,MMP9,SPTAN1,EPHA10,NPPA,HSPA14,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,NUCB2,PGF,CCL5,VEGFA |
| GO:0007154 | cell communication | 37 | 5320 | 0.38 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,EPHB4,ADORA3,MMP9,SPTAN1,EPHA10,NPPA,OPTN,MBP,GSTP1,TF,CD44,MYOCD,BDNF,NUCB2,PGF,CCL5,VEGFA |
| GO:0051128 | regulation of cellular component organization | 25 | 2402 | 0.55 | MYOC,TGFB1,GDF15,CDH2,THY1,AIFM1,CLU,LILRB1,SELE,MAPT,APOD,HTT,MMP9,VDAC2,SPTAN1,NAIF1,NPPA,OPTN,CST3,TF,CD44,MYOCD,BDNF,ENO2,VEGFA |
| GO:0048519 | negative regulation of biological process | 37 | 5389 | 0.37 | MYOC,PSMA4,CEACAM6,TGFB1,GDF15,TRIM21,CDH2,SOD1,THY1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,MAPT,BTG3,APOD,HTT,ADORA3,MMP9,VDAC2,SPTAN1,NAIF1,NPPA,OPTN,PC,MBP,CST3,GSTP1,CD44,MYOCD,BDNF,MLIP,NUCB2,CCL5,VEGFA |
| GO:0042221 | response to chemical | 33 | 4333 | 0.42 | PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,SOD1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,APOD,PLA2G4A,MMP9,SPTAN1,EPHA10,NPPA,HSPA14,OPTN,MBP,CST3,GSTP1,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0042327 | positive regulation of phosphorylation | 17 | 1093 | 0.73 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,CLU,MAPT,EPHB4,MMP9,EPHA10,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0045859 | regulation of protein kinase activity | 15 | 812 | 0.8 | TGFB1,GDF15,CHI3L1,SOD1,THY1,DUSP2,CLU,HTT,NPPA,GSTP1,TF,MYOCD,BDNF,CCL5,VEGFA |
| GO:0009893 | positive regulation of metabolic process | 31 | 3893 | 0.44 | CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,HTT,EPHB4,MMP9,EPHA10,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0080134 | regulation of response to stress | 19 | 1437 | 0.66 | PSMA4,SOD1,THY1,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,APOD,PLA2G4A,NPPA,OPTN,GSTP1,TF,CD44,MLIP,CCL5,VEGFA |
| GO:0065007 | biological regulation | 54 | 12171 | 0.18 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,BTG3,APOD,HTT,EPHB4,PLA2G4A,ADORA3,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,EPHA10,NAIF1,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0051179 | localization | 37 | 5591 | 0.36 | PSMA4,CEACAM6,CCL22,TGFB1,TTR,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,APOD,HTT,EPHB4,PLA2G4A,PGAM1,MMP9,VDAC2,SPTAN1,NAIF1,OPTN,CST3,GSTP1,TF,CD44,BDNF,CCL5,VEGFA |
| GO:0006950 | response to stress | 29 | 3485 | 0.46 | PSMA4,CCL22,TGFB1,TRIM21,CHI3L1,SOD1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,APOD,ADORA3,MMP9,NPPA,HSPA14,OPTN,CST3,GSTP1,TF,CD44,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:1902531 | regulation of intracellular signal transduction | 21 | 1807 | 0.6 | MYOC,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,DUSP2,CLU,MAPT,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,TF,CD44,CCL5,VEGFA |
| GO:0043408 | regulation of MAPK cascade | 14 | 725 | 0.82 | MYOC,CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,DUSP2,NPPA,GSTP1,TF,CD44,CCL5,VEGFA |
| GO:0010646 | regulation of cell communication | 29 | 3514 | 0.45 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,LILRB1,NOS2,MAPT,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,TF,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0031323 | regulation of cellular metabolic process | 39 | 6239 | 0.33 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,APOD,HTT,EPHB4,ADORA3,PGAM1,MMP9,EPHA10,NPPA,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0060548 | negative regulation of cell death | 16 | 999 | 0.74 | CEACAM6,SOD1,ALB,NOS3,CLU,LILRB1,HTT,MMP9,VDAC2,CST3,GSTP1,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0009967 | positive regulation of signal transduction | 20 | 1654 | 0.62 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,NOS3,CLU,HTT,MMP9,NPPA,TF,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0032101 | regulation of response to external stimulus | 16 | 1013 | 0.73 | PSMA4,TGFB1,SOD1,NOS3,LILRB1,NOS2,SELE,APOD,PLA2G4A,NPPA,OPTN,GSTP1,NUCB2,PGF,CCL5,VEGFA |
| GO:0043085 | positive regulation of catalytic activity | 19 | 1489 | 0.64 | CCL22,TGFB1,GDF15,CHI3L1,SOD1,THY1,AIFM1,NOS3,CLU,NOS2,SELE,MAPT,EPHB4,EPHA10,MBP,TF,BDNF,CCL5,VEGFA |
| GO:0023051 | regulation of signaling | 29 | 3553 | 0.45 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,LILRB1,NOS2,MAPT,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,TF,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0019222 | regulation of metabolic process | 41 | 6948 | 0.31 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,APOD,HTT,EPHB4,ADORA3,PGAM1,MMP9,EPHA10,NPPA,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0009966 | regulation of signal transduction | 27 | 3107 | 0.47 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,MAPT,APOD,HTT,MMP9,VDAC2,NPPA,OPTN,GSTP1,TF,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0048523 | negative regulation of cellular process | 34 | 4874 | 0.38 | MYOC,PSMA4,CEACAM6,TGFB1,GDF15,TRIM21,CDH2,SOD1,THY1,DUSP2,ALB,NOS3,CLU,LILRB1,MAPT,BTG3,APOD,HTT,ADORA3,MMP9,VDAC2,SPTAN1,NAIF1,NPPA,OPTN,MBP,CST3,GSTP1,CD44,MYOCD,BDNF,MLIP,CCL5,VEGFA |
| GO:0043066 | negative regulation of apoptotic process | 15 | 893 | 0.76 | CEACAM6,SOD1,ALB,NOS3,CLU,LILRB1,HTT,MMP9,VDAC2,GSTP1,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0060255 | regulation of macromolecule metabolic process | 39 | 6407 | 0.32 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,APOD,HTT,ADORA3,PGAM1,MMP9,NPPA,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0048518 | positive regulation of biological process | 38 | 6112 | 0.33 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,HTT,EPHB4,PLA2G4A,MMP9,EPHA10,NPPA,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0032879 | regulation of localization | 25 | 2740 | 0.5 | MYOC,CEACAM6,TGFB1,TRIM21,CDH2,SOD1,THY1,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,APOD,HTT,ADORA3,MMP9,NPPA,GSTP1,TF,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0007166 | cell surface receptor signaling pathway | 23 | 2325 | 0.53 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,SOD1,THY1,NOS3,LILRB1,NOS2,BSG,EPHB4,ADORA3,MMP9,EPHA10,NPPA,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:2000145 | regulation of cell motility | 15 | 929 | 0.74 | MYOC,CEACAM6,TGFB1,THY1,NOS3,SELE,APOD,ADORA3,MMP9,GSTP1,TF,MYOCD,PGF,CCL5,VEGFA |
| GO:0050789 | regulation of biological process | 52 | 11475 | 0.19 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,BTG3,APOD,HTT,EPHB4,PLA2G4A,ADORA3,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,EPHA10,NAIF1,NPPA,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0048522 | positive regulation of cellular process | 36 | 5579 | 0.35 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,THY1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,MAPT,HTT,EPHB4,PLA2G4A,MMP9,EPHA10,NPPA,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0010033 | response to organic substance | 26 | 3011 | 0.47 | PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,SOD1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,MMP9,NPPA,HSPA14,OPTN,CST3,GSTP1,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0042127 | regulation of cell population proliferation | 19 | 1642 | 0.6 | CEACAM6,TGFB1,CDH2,NOS3,CLU,LILRB1,NOS2,BTG3,APOD,PLA2G4A,ADORA3,MMP9,CST3,GSTP1,MYOCD,BDNF,PGF,CCL5,VEGFA |
| GO:0002274 | myeloid leukocyte activation | 12 | 585 | 0.85 | CEACAM6,TTR,CHI3L1,CLU,MAPT,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44,CCL5 |
| GO:0007165 | signal transduction | 33 | 4876 | 0.37 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,BSG,EPHB4,ADORA3,MMP9,SPTAN1,EPHA10,NPPA,OPTN,MBP,TF,CD44,BDNF,NUCB2,PGF,CCL5,VEGFA |
| GO:0000302 | response to reactive oxygen species | 8 | 198 | 1.14 | SOD1,AIFM1,NOS3,MAPT,APOD,MMP9,CST3,GSTP1 |
| GO:0030334 | regulation of cell migration | 14 | 865 | 0.74 | MYOC,CEACAM6,TGFB1,THY1,NOS3,SELE,APOD,ADORA3,MMP9,GSTP1,MYOCD,PGF,CCL5,VEGFA |
| GO:0050896 | response to stimulus | 43 | 8046 | 0.26 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,APOD,HTT,EPHB4,PLA2G4A,ADORA3,PGAM1,MMP9,SPTAN1,EPHA10,NPPA,HSPA14,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,NUCB2,PGF,CCL5,VEGFA |
| GO:0065009 | regulation of molecular function | 33 | 4913 | 0.36 | CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,DUSP2,NOS3,CLU,NOS2,SELE,MAPT,HTT,EPHB4,ADORA3,MMP9,EPHA10,NPPA,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,NUCB2,PGF,CCL5,VEGFA |
| GO:0070887 | cellular response to chemical stimulus | 25 | 2919 | 0.47 | PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,SOD1,AIFM1,ALB,NOS3,LILRB1,NOS2,MAPT,PLA2G4A,MMP9,HSPA14,OPTN,CST3,GSTP1,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0023052 | signaling | 34 | 5239 | 0.35 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,SOD1,THY1,AIFM1,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,EPHB4,ADORA3,MMP9,SPTAN1,EPHA10,NPPA,OPTN,MBP,TF,CD44,BDNF,NUCB2,PGF,CCL5,VEGFA |
| GO:1902533 | positive regulation of intracellular signal transduction | 15 | 1041 | 0.69 | MYOC,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,CLU,HTT,NPPA,TF,CD44,CCL5,VEGFA |
| GO:0033674 | positive regulation of kinase activity | 12 | 624 | 0.82 | TGFB1,GDF15,CHI3L1,SOD1,CLU,MAPT,EPHB4,EPHA10,TF,BDNF,CCL5,VEGFA |
| GO:0050794 | regulation of cellular process | 50 | 10932 | 0.2 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,SELE,BSG,MAPT,BTG3,APOD,HTT,EPHB4,PLA2G4A,ADORA3,PGAM1,MMP9,VDAC2,SPTAN1,EPHA10,NAIF1,NPPA,OPTN,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0043067 | regulation of programmed cell death | 18 | 1569 | 0.6 | CEACAM6,SOD1,AIFM1,ALB,NOS3,CLU,LILRB1,MAPT,HTT,MMP9,VDAC2,CST3,GSTP1,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 11 | 521 | 0.86 | TGFB1,GDF15,SOD1,THY1,DUSP2,HTT,NPPA,GSTP1,TF,MYOCD,VEGFA |
| GO:0022603 | regulation of anatomical structure morphogenesis | 15 | 1095 | 0.67 | MYOC,PSMA4,TGFB1,GDF15,CHI3L1,CDH2,THY1,NOS3,MAPT,MBP,CST3,CD44,BDNF,PGF,VEGFA |
| GO:0051248 | negative regulation of protein metabolic process | 15 | 1096 | 0.67 | TGFB1,TRIM21,THY1,DUSP2,CLU,NOS2,MAPT,APOD,MMP9,NPPA,CST3,GSTP1,CD44,MYOCD,VEGFA |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 8 | 232 | 1.07 | NOS3,CLU,HTT,MMP9,VDAC2,GSTP1,CD44,BDNF |
| GO:0016192 | vesicle-mediated transport | 19 | 1805 | 0.56 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,ALB,CLU,LILRB1,HTT,PGAM1,MMP9,SPTAN1,OPTN,CST3,GSTP1,TF,CD44,CCL5,VEGFA |
| GO:2000147 | positive regulation of cell motility | 11 | 547 | 0.84 | MYOC,CEACAM6,TGFB1,THY1,NOS3,SELE,MMP9,TF,PGF,CCL5,VEGFA |
| GO:0006810 | transport | 30 | 4353 | 0.37 | PSMA4,CEACAM6,TGFB1,TTR,CHI3L1,ABCB6,SOD1,EIF2D,AIFM1,ALB,CLU,LILRB1,NOS2,MAPT,APOD,HTT,PLA2G4A,PGAM1,MMP9,VDAC2,SPTAN1,NAIF1,OPTN,CST3,GSTP1,TF,CD44,BDNF,CCL5,VEGFA |
| GO:0032930 | positive regulation of superoxide anion generation | 4 | 20 | 1.84 | TGFB1,SOD1,MAPT,GSTP1 |
| GO:1901564 | organonitrogen compound metabolic process | 33 | 5244 | 0.33 | PSMA4,TGFB1,TTR,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,DUSP2,ALB,NOS3,CLU,NOS2,MAPT,EPHB4,PLA2G4A,PGAM1,MMP9,SPTAN1,EPHA10,NPPA,HSPA14,PC,MBP,CST3,GSTP1,TF,CASP14,CD44,ENO2,CCL5 |
| GO:0006928 | movement of cell or subcellular component | 17 | 1501 | 0.59 | CEACAM6,CCL22,TGFB1,CDH2,SOD1,NOS3,SELE,BSG,MAPT,HTT,EPHB4,SPTAN1,EPHA10,CD44,BDNF,CCL5,VEGFA |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35 | 5836 | 0.31 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,NOS3,CLU,LILRB1,NOS2,MAPT,APOD,HTT,ADORA3,PGAM1,MMP9,NPPA,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0051641 | cellular localization | 24 | 2967 | 0.44 | CEACAM6,TGFB1,TTR,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,ALB,CLU,NOS2,BSG,MAPT,HTT,PGAM1,MMP9,SPTAN1,OPTN,CST3,GSTP1,TF,CD44,VEGFA |
| GO:0001934 | positive regulation of protein phosphorylation | 14 | 1019 | 0.67 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,CLU,MMP9,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0042981 | regulation of apoptotic process | 17 | 1550 | 0.58 | CEACAM6,SOD1,AIFM1,ALB,NOS3,CLU,LILRB1,MAPT,HTT,MMP9,VDAC2,GSTP1,CD44,MYOCD,BDNF,CCL5,VEGFA |
| GO:0034114 | regulation of heterotypic cell-cell adhesion | 4 | 25 | 1.74 | CEACAM6,THY1,MBP,CD44 |
| GO:0071310 | cellular response to organic substance | 21 | 2369 | 0.48 | PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,SOD1,AIFM1,NOS3,LILRB1,NOS2,MAPT,MMP9,HSPA14,OPTN,GSTP1,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0006955 | immune response | 17 | 1588 | 0.57 | CEACAM6,CCL22,TTR,TRIM21,CHI3L1,CLU,LILRB1,NOS2,PGAM1,MMP9,SPTAN1,OPTN,MBP,CST3,GSTP1,CD44,CCL5 |
| GO:0042119 | neutrophil activation | 10 | 497 | 0.84 | CEACAM6,TTR,CHI3L1,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44,CCL5 |
| GO:0080090 | regulation of primary metabolic process | 35 | 6032 | 0.3 | MYOC,PSMA4,CCL22,TGFB1,GDF15,TRIM21,CHI3L1,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,NOS3,CLU,LILRB1,NOS2,MAPT,APOD,HTT,ADORA3,PGAM1,MMP9,NPPA,MBP,CST3,GSTP1,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0040011 | locomotion | 15 | 1251 | 0.61 | CEACAM6,CCL22,TGFB1,CDH2,NOS3,SELE,BSG,EPHB4,SPTAN1,EPHA10,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0045321 | leukocyte activation | 13 | 929 | 0.68 | CEACAM6,TTR,CHI3L1,CLU,LILRB1,MAPT,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44,CCL5 |
| GO:0006954 | inflammatory response | 10 | 515 | 0.82 | CCL22,TGFB1,CHI3L1,CLU,NOS2,SELE,MAPT,ADORA3,CD44,CCL5 |
| GO:0002576 | platelet degranulation | 6 | 129 | 1.2 | TGFB1,SOD1,ALB,CLU,TF,VEGFA |
| GO:0032270 | positive regulation of cellular protein metabolic process | 17 | 1635 | 0.55 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,AIFM1,CLU,MAPT,MMP9,MBP,TF,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0030335 | positive regulation of cell migration | 10 | 522 | 0.82 | MYOC,CEACAM6,TGFB1,THY1,NOS3,SELE,MMP9,PGF,CCL5,VEGFA |
| GO:0051336 | regulation of hydrolase activity | 15 | 1284 | 0.6 | CCL22,SOD1,THY1,AIFM1,NOS3,SELE,MAPT,HTT,MMP9,MBP,CST3,CD44,BDNF,CCL5,VEGFA |
| GO:0034614 | cellular response to reactive oxygen species | 6 | 133 | 1.19 | SOD1,AIFM1,NOS3,MAPT,MMP9,CST3 |
| GO:0048514 | blood vessel morphogenesis | 9 | 410 | 0.88 | TGFB1,CDH2,THY1,NOS3,APOD,EPHB4,MYOCD,PGF,VEGFA |
| GO:0048731 | system development | 29 | 4426 | 0.35 | MYOC,TGFB1,CHI3L1,ABCB6,CDH2,SOD1,THY1,AIFM1,NOS3,CLU,LILRB1,BSG,MAPT,APOD,EPHB4,MMP9,SPTAN1,EPHA10,NPPA,MBP,CST3,GSTP1,TF,CASP14,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:2001233 | regulation of apoptotic signaling pathway | 9 | 409 | 0.88 | SOD1,NOS3,CLU,HTT,MMP9,VDAC2,GSTP1,CD44,BDNF |
| GO:0006952 | defense response | 15 | 1296 | 0.6 | CCL22,TGFB1,TRIM21,CHI3L1,CLU,LILRB1,NOS2,SELE,MAPT,ADORA3,OPTN,CST3,CD44,BDNF,CCL5 |
| GO:0048660 | regulation of smooth muscle cell proliferation | 6 | 136 | 1.18 | NOS3,APOD,MMP9,GSTP1,MYOCD,CCL5 |
| GO:0043410 | positive regulation of MAPK cascade | 10 | 543 | 0.8 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,TF,CD44,CCL5,VEGFA |
| GO:0048513 | animal organ development | 24 | 3197 | 0.41 | MYOC,TGFB1,CHI3L1,ABCB6,CDH2,SOD1,THY1,NOS3,LILRB1,BSG,APOD,EPHB4,MMP9,NPPA,MBP,CST3,GSTP1,TF,CASP14,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:0022407 | regulation of cell-cell adhesion | 9 | 424 | 0.86 | CEACAM6,TGFB1,THY1,LILRB1,SELE,MBP,CD44,CCL5,VEGFA |
| GO:0050900 | leukocyte migration | 8 | 316 | 0.94 | CEACAM6,CCL22,TGFB1,SELE,BSG,CD44,CCL5,VEGFA |
| GO:0044092 | negative regulation of molecular function | 14 | 1163 | 0.62 | TRIM21,THY1,DUSP2,NOS3,MAPT,ADORA3,MMP9,NPPA,CST3,GSTP1,CD44,MYOCD,CCL5,VEGFA |
| GO:0030155 | regulation of cell adhesion | 11 | 712 | 0.72 | MYOC,CEACAM6,TGFB1,THY1,LILRB1,SELE,APOD,MBP,CD44,CCL5,VEGFA |
| GO:0051129 | negative regulation of cellular component organization | 11 | 713 | 0.72 | MYOC,TGFB1,THY1,CLU,LILRB1,MAPT,APOD,VDAC2,SPTAN1,CST3,VEGFA |
| GO:0065008 | regulation of biological quality | 27 | 4042 | 0.36 | MYOC,PSMA4,TGFB1,TTR,TRIM21,ABCB6,CDH2,SOD1,THY1,ALB,NOS3,CLU,NOS2,MAPT,HTT,PLA2G4A,SPTAN1,NAIF1,NPPA,HSPA14,MBP,GSTP1,TF,BDNF,NUCB2,CCL5,VEGFA |
| GO:0051649 | establishment of localization in cell | 20 | 2375 | 0.46 | CEACAM6,TGFB1,TTR,CHI3L1,SOD1,EIF2D,AIFM1,ALB,CLU,NOS2,MAPT,HTT,PGAM1,MMP9,SPTAN1,CST3,GSTP1,TF,CD44,VEGFA |
| GO:0007167 | enzyme linked receptor protein signaling pathway | 11 | 720 | 0.72 | MYOC,TGFB1,GDF15,EPHB4,MMP9,EPHA10,NPPA,TF,BDNF,PGF,VEGFA |
| GO:0009888 | tissue development | 17 | 1760 | 0.52 | TGFB1,CHI3L1,CDH2,SOD1,DUSP2,NOS3,BSG,APOD,MMP9,NPPA,CST3,CASP14,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:0043405 | regulation of MAP kinase activity | 8 | 342 | 0.9 | TGFB1,GDF15,SOD1,DUSP2,NPPA,GSTP1,TF,VEGFA |
| GO:0034599 | cellular response to oxidative stress | 7 | 244 | 0.99 | SOD1,AIFM1,NOS3,MAPT,MMP9,CST3,GSTP1 |
| GO:0051240 | positive regulation of multicellular organismal process | 17 | 1770 | 0.52 | TGFB1,CHI3L1,SOD1,NOS3,CLU,LILRB1,BSG,MAPT,PLA2G4A,MMP9,NPPA,MBP,TF,MYOCD,BDNF,PGF,VEGFA |
| GO:0007566 | embryo implantation | 4 | 41 | 1.52 | SOD1,BSG,MMP9,CST3 |
| GO:0036293 | response to decreased oxygen levels | 8 | 354 | 0.89 | PSMA4,AIFM1,NOS2,NPPA,CST3,MYOCD,PGF,VEGFA |
| GO:0051241 | negative regulation of multicellular organismal process | 14 | 1231 | 0.59 | TGFB1,GDF15,SOD1,THY1,NOS3,LILRB1,APOD,MMP9,NPPA,CST3,GSTP1,MYOCD,BDNF,MLIP |
| GO:0043312 | neutrophil degranulation | 9 | 484 | 0.81 | CEACAM6,TTR,CHI3L1,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44 |
| GO:0002366 | leukocyte activation involved in immune response | 10 | 626 | 0.74 | CEACAM6,TTR,CHI3L1,LILRB1,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44 |
| GO:0007275 | multicellular organism development | 30 | 5023 | 0.31 | MYOC,TGFB1,CHI3L1,ABCB6,CDH2,SOD1,THY1,AIFM1,DUSP2,NOS3,CLU,LILRB1,BSG,MAPT,APOD,EPHB4,MMP9,SPTAN1,EPHA10,NPPA,MBP,CST3,GSTP1,TF,CASP14,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:0048662 | negative regulation of smooth muscle cell proliferation | 4 | 46 | 1.47 | NOS3,APOD,GSTP1,MYOCD |
| GO:0071363 | cellular response to growth factor stimulus | 9 | 494 | 0.8 | TGFB1,GDF15,MAPT,GSTP1,CD44,BDNF,PGF,CCL5,VEGFA |
| GO:0002443 | leukocyte mediated immunity | 10 | 641 | 0.73 | CEACAM6,TTR,CHI3L1,CLU,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44 |
| GO:0010001 | glial cell differentiation | 6 | 178 | 1.06 | MYOC,CDH2,SOD1,CLU,MAPT,GSTP1 |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 5 | 103 | 1.22 | TGFB1,SOD1,CLU,MAPT,GSTP1 |
| GO:0002684 | positive regulation of immune system process | 12 | 949 | 0.64 | PSMA4,TGFB1,THY1,CLU,LILRB1,NOS2,SELE,PLA2G4A,NPPA,PGF,CCL5,VEGFA |
| GO:1902532 | negative regulation of intracellular signal transduction | 9 | 508 | 0.78 | MYOC,DUSP2,CLU,MMP9,VDAC2,NPPA,OPTN,GSTP1,CD44 |
| GO:0007565 | female pregnancy | 6 | 183 | 1.05 | SOD1,BSG,MMP9,NPPA,CST3,PGF |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 9 | 518 | 0.78 | MYOC,TGFB1,GDF15,EPHB4,MMP9,EPHA10,BDNF,PGF,VEGFA |
| GO:0043086 | negative regulation of catalytic activity | 11 | 807 | 0.67 | THY1,DUSP2,NOS3,MAPT,MMP9,NPPA,CST3,GSTP1,CD44,MYOCD,VEGFA |
| GO:0071222 | cellular response to lipopolysaccharide | 6 | 185 | 1.05 | TGFB1,NOS3,LILRB1,NOS2,GSTP1,CCL5 |
| GO:0009628 | response to abiotic stimulus | 13 | 1147 | 0.59 | PSMA4,CHI3L1,SOD1,AIFM1,NOS3,NOS2,MAPT,HTT,NPPA,CST3,MYOCD,PGF,VEGFA |
| GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 3 | 16 | 1.81 | CEACAM6,THY1,CD44 |
| GO:0021782 | glial cell development | 5 | 112 | 1.19 | MYOC,SOD1,CLU,MAPT,GSTP1 |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 4 | 53 | 1.41 | CLU,SELE,TF,VEGFA |
| GO:0031347 | regulation of defense response | 10 | 674 | 0.71 | PSMA4,SOD1,LILRB1,NOS2,SELE,APOD,NPPA,OPTN,GSTP1,CCL5 |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 7 | 292 | 0.92 | CCL22,TGFB1,CHI3L1,GSTP1,CD44,CCL5,VEGFA |
| GO:0001954 | positive regulation of cell-matrix adhesion | 4 | 55 | 1.4 | MYOC,CEACAM6,THY1,VEGFA |
| GO:0019221 | cytokine-mediated signaling pathway | 10 | 678 | 0.7 | PSMA4,CCL22,TGFB1,TRIM21,SOD1,NOS2,MMP9,CD44,CCL5,VEGFA |
| GO:0009653 | anatomical structure morphogenesis | 18 | 2165 | 0.46 | TGFB1,CDH2,SOD1,THY1,DUSP2,NOS3,CLU,BSG,APOD,EPHB4,MMP9,SPTAN1,EPHA10,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24 | 3600 | 0.36 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,AIFM1,NOS3,CLU,LILRB1,SELE,BSG,MAPT,MMP9,MBP,CST3,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0045860 | positive regulation of protein kinase activity | 9 | 550 | 0.75 | TGFB1,GDF15,CHI3L1,SOD1,CLU,TF,BDNF,CCL5,VEGFA |
| GO:0001952 | regulation of cell-matrix adhesion | 5 | 120 | 1.16 | MYOC,CEACAM6,THY1,APOD,VEGFA |
| GO:0035295 | tube development | 11 | 851 | 0.65 | TGFB1,CHI3L1,CDH2,THY1,NOS3,APOD,EPHB4,MYOCD,BDNF,PGF,VEGFA |
| GO:1901700 | response to oxygen-containing compound | 15 | 1567 | 0.52 | TGFB1,SOD1,AIFM1,NOS3,LILRB1,NOS2,SELE,BSG,MAPT,APOD,MMP9,NPPA,CST3,GSTP1,CCL5 |
| GO:0019752 | carboxylic acid metabolic process | 11 | 853 | 0.65 | TGFB1,NOS3,NOS2,BSG,PLA2G4A,PGAM1,PTGDS,PC,GSTP1,CD44,ENO2 |
| GO:0045785 | positive regulation of cell adhesion | 8 | 423 | 0.81 | MYOC,CEACAM6,THY1,LILRB1,SELE,CD44,CCL5,VEGFA |
| GO:0051049 | regulation of transport | 16 | 1776 | 0.49 | TGFB1,CDH2,SOD1,THY1,NOS3,CLU,LILRB1,NOS2,SELE,APOD,HTT,MMP9,NPPA,TF,CCL5,VEGFA |
| GO:0002685 | regulation of leukocyte migration | 6 | 209 | 0.99 | THY1,SELE,APOD,PGF,CCL5,VEGFA |
| GO:0032496 | response to lipopolysaccharide | 7 | 313 | 0.89 | TGFB1,NOS3,LILRB1,NOS2,SELE,GSTP1,CCL5 |
| GO:0051130 | positive regulation of cellular component organization | 13 | 1209 | 0.57 | MYOC,TGFB1,GDF15,THY1,CLU,SELE,MAPT,HTT,MMP9,OPTN,TF,BDNF,VEGFA |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 6 | 209 | 0.99 | CCL22,TGFB1,CHI3L1,CD44,CCL5,VEGFA |
| GO:0032269 | negative regulation of cellular protein metabolic process | 12 | 1043 | 0.6 | TGFB1,TRIM21,THY1,DUSP2,MAPT,MMP9,NPPA,CST3,GSTP1,CD44,MYOCD,VEGFA |
| GO:0051893 | regulation of focal adhesion assembly | 4 | 63 | 1.34 | MYOC,THY1,APOD,VEGFA |
| GO:0001894 | tissue homeostasis | 6 | 219 | 0.97 | SOD1,ALB,NOS3,MBP,TF,VEGFA |
| GO:0009636 | response to toxic substance | 6 | 219 | 0.97 | SOD1,ALB,NOS3,MBP,GSTP1,CCL5 |
| GO:0016477 | cell migration | 11 | 896 | 0.62 | CEACAM6,CCL22,TGFB1,CDH2,NOS3,SELE,BSG,EPHB4,CD44,CCL5,VEGFA |
| GO:0001817 | regulation of cytokine production | 10 | 742 | 0.67 | TGFB1,TRIM21,SOD1,CLU,LILRB1,NOS2,BSG,APOD,MBP,GSTP1 |
| GO:0051707 | response to other organism | 13 | 1256 | 0.55 | CCL22,TGFB1,TRIM21,NOS3,CLU,LILRB1,NOS2,SELE,OPTN,GSTP1,TF,CD44,CCL5 |
| GO:0009719 | response to endogenous stimulus | 14 | 1447 | 0.52 | TGFB1,GDF15,SOD1,AIFM1,NOS3,NOS2,BSG,MAPT,NPPA,GSTP1,CD44,BDNF,PGF,CCL5 |
| GO:0006090 | pyruvate metabolic process | 4 | 69 | 1.3 | BSG,PGAM1,PC,ENO2 |
| GO:0022008 | neurogenesis | 15 | 1657 | 0.49 | MYOC,TGFB1,CDH2,SOD1,THY1,AIFM1,CLU,BSG,MAPT,APOD,SPTAN1,EPHA10,GSTP1,BDNF,VEGFA |
| GO:0032501 | multicellular organismal process | 35 | 6933 | 0.24 | MYOC,TGFB1,GDF15,CHI3L1,ABCB6,CDH2,SOD1,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,BSG,MAPT,APOD,HTT,EPHB4,CALD1,MMP9,SPTAN1,EPHA10,NPPA,MBP,CST3,GSTP1,TF,CASP14,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22 | 3239 | 0.37 | CCL22,TGFB1,GDF15,CHI3L1,CDH2,SOD1,AIFM1,NOS3,CLU,LILRB1,NOS2,MAPT,MMP9,MBP,TF,CD44,MYOCD,BDNF,MLIP,PGF,CCL5,VEGFA |
| GO:0001666 | response to hypoxia | 7 | 342 | 0.85 | PSMA4,NOS2,NPPA,CST3,MYOCD,PGF,VEGFA |
| GO:0051050 | positive regulation of transport | 11 | 923 | 0.61 | TGFB1,CDH2,SOD1,THY1,CLU,SELE,HTT,NPPA,TF,CCL5,VEGFA |
| GO:0008152 | metabolic process | 39 | 8298 | 0.21 | PSMA4,TGFB1,TTR,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,BSG,MAPT,APOD,EPHB4,PLA2G4A,PGAM1,PTGDS,MMP9,SPTAN1,EPHA10,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,CASP14,CD44,ENO2,CCL5 |
| GO:0034097 | response to cytokine | 12 | 1101 | 0.57 | PSMA4,CCL22,TGFB1,TRIM21,CHI3L1,SOD1,NOS2,SELE,MMP9,CD44,CCL5,VEGFA |
| GO:0002687 | positive regulation of leukocyte migration | 5 | 144 | 1.08 | THY1,SELE,PGF,CCL5,VEGFA |
| GO:0051894 | positive regulation of focal adhesion assembly | 3 | 25 | 1.61 | MYOC,THY1,VEGFA |
| GO:1903409 | reactive oxygen species biosynthetic process | 3 | 25 | 1.61 | SOD1,NOS3,NOS2 |
| GO:0044419 | interspecies interaction between organisms | 16 | 1899 | 0.46 | PSMA4,CCL22,TGFB1,TRIM21,EIF2D,NOS3,CLU,LILRB1,NOS2,SELE,OPTN,PC,GSTP1,TF,CD44,CCL5 |
| GO:0050727 | regulation of inflammatory response | 7 | 351 | 0.84 | SOD1,NOS2,SELE,APOD,NPPA,GSTP1,CCL5 |
| GO:0002682 | regulation of immune system process | 14 | 1514 | 0.5 | PSMA4,TGFB1,SOD1,THY1,CLU,LILRB1,NOS2,SELE,APOD,PLA2G4A,NPPA,PGF,CCL5,VEGFA |
| GO:0007399 | nervous system development | 18 | 2371 | 0.42 | MYOC,TGFB1,ABCB6,CDH2,SOD1,THY1,AIFM1,CLU,BSG,MAPT,APOD,SPTAN1,EPHA10,MBP,CST3,GSTP1,BDNF,VEGFA |
| GO:0009617 | response to bacterium | 9 | 634 | 0.69 | TGFB1,NOS3,LILRB1,NOS2,SELE,OPTN,GSTP1,TF,CCL5 |
| GO:0051147 | regulation of muscle cell differentiation | 5 | 154 | 1.05 | TGFB1,GDF15,CDH2,MYOCD,BDNF |
| GO:0002252 | immune effector process | 11 | 969 | 0.59 | CEACAM6,TTR,CHI3L1,CLU,LILRB1,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44 |
| GO:0044087 | regulation of cellular component biogenesis | 11 | 971 | 0.59 | MYOC,TGFB1,THY1,CLU,MAPT,APOD,HTT,VDAC2,SPTAN1,BDNF,VEGFA |
| GO:0071704 | organic substance metabolic process | 37 | 7755 | 0.21 | PSMA4,TGFB1,TTR,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,BSG,MAPT,APOD,EPHB4,PLA2G4A,PGAM1,PTGDS,MMP9,SPTAN1,EPHA10,NPPA,HSPA14,PC,MBP,CST3,GSTP1,TF,CASP14,CD44,ENO2,CCL5 |
| GO:0033673 | negative regulation of kinase activity | 6 | 255 | 0.91 | THY1,DUSP2,MAPT,NPPA,GSTP1,MYOCD |
| GO:0051924 | regulation of calcium ion transport | 6 | 256 | 0.91 | THY1,NOS3,LILRB1,HTT,NPPA,CCL5 |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 6 | 258 | 0.9 | TGFB1,THY1,CD44,BDNF,CCL5,VEGFA |
| GO:0050793 | regulation of developmental process | 19 | 2648 | 0.39 | MYOC,PSMA4,TGFB1,GDF15,CHI3L1,CDH2,SOD1,THY1,NOS3,LILRB1,MAPT,MMP9,MBP,CST3,CD44,MYOCD,BDNF,PGF,VEGFA |
| GO:0051093 | negative regulation of developmental process | 11 | 983 | 0.58 | TGFB1,GDF15,THY1,NOS3,LILRB1,MAPT,MMP9,CST3,MYOCD,BDNF,VEGFA |
| GO:0071346 | cellular response to interferon-gamma | 5 | 161 | 1.03 | CCL22,TRIM21,NOS2,CD44,CCL5 |
| GO:0010716 | negative regulation of extracellular matrix disassembly | 2 | 4 | 2.23 | TGFB1,CST3 |
| GO:0030336 | negative regulation of cell migration | 6 | 262 | 0.9 | TGFB1,THY1,APOD,ADORA3,GSTP1,MYOCD |
| GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 5 | 164 | 1.02 | SOD1,CLU,MMP9,VDAC2,CD44 |
| GO:0048666 | neuron development | 10 | 827 | 0.62 | MYOC,SOD1,THY1,BSG,MAPT,APOD,SPTAN1,EPHA10,BDNF,VEGFA |
| GO:0043500 | muscle adaptation | 3 | 32 | 1.51 | MYOC,NOS3,NPPA |
| GO:0010959 | regulation of metal ion transport | 7 | 391 | 0.79 | THY1,NOS3,LILRB1,HTT,NPPA,TF,CCL5 |
| GO:0040008 | regulation of growth | 9 | 676 | 0.66 | TGFB1,GDF15,SOD1,MAPT,NAIF1,NPPA,MYOCD,BDNF,VEGFA |
| GO:0051149 | positive regulation of muscle cell differentiation | 4 | 88 | 1.19 | TGFB1,GDF15,CDH2,MYOCD |
| GO:0022409 | positive regulation of cell-cell adhesion | 6 | 272 | 0.88 | CEACAM6,THY1,LILRB1,SELE,CD44,CCL5 |
| GO:0030154 | cell differentiation | 23 | 3702 | 0.33 | MYOC,TGFB1,CDH2,SOD1,THY1,AIFM1,CLU,LILRB1,BSG,MAPT,APOD,MMP9,SPTAN1,EPHA10,NPPA,CST3,GSTP1,TF,CASP14,MYOCD,BDNF,PGF,VEGFA |
| GO:0071345 | cellular response to cytokine stimulus | 11 | 1013 | 0.57 | PSMA4,CCL22,TGFB1,TRIM21,CHI3L1,SOD1,NOS2,MMP9,CD44,CCL5,VEGFA |
| GO:0031175 | neuron projection development | 9 | 680 | 0.66 | MYOC,SOD1,BSG,MAPT,APOD,SPTAN1,EPHA10,BDNF,VEGFA |
| GO:0030182 | neuron differentiation | 11 | 1019 | 0.57 | MYOC,SOD1,THY1,AIFM1,BSG,MAPT,APOD,SPTAN1,EPHA10,BDNF,VEGFA |
| GO:0042311 | vasodilation | 3 | 33 | 1.49 | SOD1,NOS3,NPPA |
| GO:0098869 | cellular oxidant detoxification | 4 | 90 | 1.18 | SOD1,ALB,NOS3,GSTP1 |
| GO:0031663 | lipopolysaccharide-mediated signaling pathway | 3 | 34 | 1.48 | TGFB1,NOS3,CCL5 |
| GO:0010035 | response to inorganic substance | 8 | 538 | 0.71 | SOD1,AIFM1,NOS3,BSG,MAPT,MMP9,CST3,TF |
| GO:0007162 | negative regulation of cell adhesion | 6 | 280 | 0.87 | MYOC,TGFB1,LILRB1,APOD,MBP,VEGFA |
| GO:0044089 | positive regulation of cellular component biogenesis | 8 | 542 | 0.7 | MYOC,TGFB1,THY1,CLU,MAPT,HTT,BDNF,VEGFA |
| GO:0008285 | negative regulation of cell population proliferation | 9 | 696 | 0.65 | TGFB1,NOS3,LILRB1,BTG3,APOD,ADORA3,GSTP1,MYOCD,BDNF |
| GO:0006935 | chemotaxis | 8 | 545 | 0.7 | CCL22,BSG,SPTAN1,EPHA10,BDNF,PGF,CCL5,VEGFA |
| GO:0048468 | cell development | 14 | 1629 | 0.47 | MYOC,SOD1,THY1,CLU,BSG,MAPT,APOD,SPTAN1,EPHA10,NPPA,CST3,GSTP1,BDNF,VEGFA |
| GO:0060627 | regulation of vesicle-mediated transport | 8 | 550 | 0.7 | CDH2,SOD1,CLU,LILRB1,SELE,NPPA,TF,VEGFA |
| GO:0072359 | circulatory system development | 10 | 872 | 0.6 | TGFB1,CDH2,THY1,NOS3,APOD,EPHB4,NPPA,MYOCD,PGF,VEGFA |
| GO:0006801 | superoxide metabolic process | 3 | 37 | 1.44 | SOD1,NOS3,NOS2 |
| GO:1901701 | cellular response to oxygen-containing compound | 11 | 1055 | 0.55 | TGFB1,SOD1,AIFM1,NOS3,LILRB1,NOS2,MAPT,MMP9,CST3,GSTP1,CCL5 |
| GO:0052548 | regulation of endopeptidase activity | 7 | 418 | 0.76 | AIFM1,MAPT,MMP9,MBP,CST3,CD44,VEGFA |
| GO:0003018 | vascular process in circulatory system | 5 | 185 | 0.97 | TGFB1,SOD1,NOS3,NPPA,VEGFA |
| GO:0060754 | positive regulation of mast cell chemotaxis | 2 | 6 | 2.06 | PGF,VEGFA |
| GO:0061564 | axon development | 7 | 421 | 0.76 | BSG,MAPT,APOD,SPTAN1,EPHA10,BDNF,VEGFA |
| GO:0071638 | negative regulation of monocyte chemotactic protein-1 production | 2 | 6 | 2.06 | APOD,GSTP1 |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 4 | 99 | 1.14 | CLU,MMP9,VDAC2,CD44 |
| GO:0001558 | regulation of cell growth | 7 | 423 | 0.75 | TGFB1,MAPT,NAIF1,NPPA,MYOCD,BDNF,VEGFA |
| GO:0050770 | regulation of axonogenesis | 5 | 187 | 0.96 | CDH2,THY1,MAPT,BDNF,VEGFA |
| GO:0006693 | prostaglandin metabolic process | 3 | 39 | 1.42 | PLA2G4A,PTGDS,GSTP1 |
| GO:1904018 | positive regulation of vasculature development | 5 | 189 | 0.96 | CHI3L1,NOS3,MYOCD,PGF,VEGFA |
| GO:0050865 | regulation of cell activation | 8 | 571 | 0.68 | TGFB1,SOD1,THY1,NOS3,LILRB1,PLA2G4A,NPPA,CCL5 |
| GO:0051153 | regulation of striated muscle cell differentiation | 4 | 102 | 1.13 | TGFB1,GDF15,MYOCD,BDNF |
| GO:1901890 | positive regulation of cell junction assembly | 4 | 102 | 1.13 | MYOC,THY1,BDNF,VEGFA |
| GO:0042592 | homeostatic process | 14 | 1676 | 0.46 | MYOC,ABCB6,CDH2,SOD1,THY1,ALB,NOS3,NOS2,HTT,MBP,GSTP1,TF,CCL5,VEGFA |
| GO:0044281 | small molecule metabolic process | 14 | 1684 | 0.46 | TGFB1,TTR,NOS3,NOS2,BSG,APOD,PLA2G4A,PGAM1,PTGDS,NPPA,PC,GSTP1,CD44,ENO2 |
| GO:0080135 | regulation of cellular response to stress | 9 | 739 | 0.62 | SOD1,THY1,CLU,MAPT,NPPA,GSTP1,TF,CD44,VEGFA |
| GO:0009987 | cellular process | 54 | 15024 | 0.09 | MYOC,PSMA4,CEACAM6,CCL22,TGFB1,TTR,GDF15,TRIM21,CHI3L1,ABCB6,CDH2,SOD1,EIF2D,THY1,AIFM1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,FBLN7,SELE,BSG,MAPT,APOD,HTT,EPHB4,PLA2G4A,ADORA3,PGAM1,PTGDS,MMP9,VDAC2,SPTAN1,EPHA10,NAIF1,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,CASP14,CD44,MYOCD,BDNF,NUCB2,ENO2,PGF,CCL5,VEGFA |
| GO:0010821 | regulation of mitochondrion organization | 5 | 196 | 0.94 | CLU,MAPT,HTT,MMP9,OPTN |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 5 | 196 | 0.94 | TGFB1,CD44,BDNF,CCL5,VEGFA |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 6 | 309 | 0.82 | MYOC,CDH2,THY1,MAPT,BDNF,VEGFA |
| GO:0030162 | regulation of proteolysis | 9 | 747 | 0.62 | TRIM21,AIFM1,CLU,MAPT,MMP9,MBP,CST3,CD44,VEGFA |
| GO:0070555 | response to interleukin-1 | 5 | 199 | 0.94 | PSMA4,CCL22,CHI3L1,SELE,CCL5 |
| GO:1901888 | regulation of cell junction assembly | 5 | 199 | 0.94 | MYOC,THY1,APOD,BDNF,VEGFA |
| GO:0035556 | intracellular signal transduction | 14 | 1712 | 0.45 | PSMA4,TGFB1,CHI3L1,AIFM1,NOS3,CLU,NOS2,SELE,SPTAN1,NPPA,MBP,TF,NUCB2,CCL5 |
| GO:0001525 | angiogenesis | 6 | 315 | 0.82 | THY1,NOS3,APOD,EPHB4,PGF,VEGFA |
| GO:0009892 | negative regulation of metabolic process | 20 | 3124 | 0.34 | TGFB1,TRIM21,SOD1,THY1,DUSP2,CLU,LILRB1,NOS2,MAPT,APOD,MMP9,NPPA,OPTN,PC,CST3,GSTP1,CD44,MYOCD,MLIP,VEGFA |
| GO:0010605 | negative regulation of macromolecule metabolic process | 19 | 2875 | 0.36 | TGFB1,TRIM21,THY1,DUSP2,CLU,LILRB1,NOS2,MAPT,APOD,MMP9,NPPA,OPTN,PC,CST3,GSTP1,CD44,MYOCD,MLIP,VEGFA |
| GO:0042326 | negative regulation of phosphorylation | 7 | 449 | 0.73 | TGFB1,THY1,DUSP2,MAPT,NPPA,GSTP1,MYOCD |
| GO:1901214 | regulation of neuron death | 6 | 317 | 0.81 | SOD1,AIFM1,CLU,MAPT,BDNF,CCL5 |
| GO:0042552 | myelination | 4 | 111 | 1.09 | MYOC,SOD1,CLU,MBP |
| GO:0033554 | cellular response to stress | 14 | 1725 | 0.44 | PSMA4,SOD1,AIFM1,ALB,NOS3,MAPT,APOD,MMP9,HSPA14,OPTN,CST3,GSTP1,TF,VEGFA |
| GO:0030100 | regulation of endocytosis | 5 | 205 | 0.92 | CLU,LILRB1,SELE,TF,VEGFA |
| GO:0031400 | negative regulation of protein modification process | 8 | 602 | 0.66 | TGFB1,TRIM21,THY1,DUSP2,MAPT,NPPA,GSTP1,MYOCD |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 4 | 112 | 1.09 | TGFB1,CD44,BDNF,VEGFA |
| GO:0032637 | interleukin-8 production | 2 | 8 | 1.93 | CHI3L1,NOS2 |
| GO:0060312 | regulation of blood vessel remodeling | 2 | 8 | 1.93 | TGFB1,CST3 |
| GO:0050778 | positive regulation of immune response | 8 | 607 | 0.66 | PSMA4,TGFB1,THY1,CLU,LILRB1,PLA2G4A,NPPA,CCL5 |
| GO:0006094 | gluconeogenesis | 3 | 46 | 1.35 | PGAM1,PC,ENO2 |
| GO:0006636 | unsaturated fatty acid biosynthetic process | 3 | 46 | 1.35 | PLA2G4A,PTGDS,GSTP1 |
| GO:0051345 | positive regulation of hydrolase activity | 9 | 772 | 0.6 | CCL22,THY1,AIFM1,SELE,MAPT,MBP,BDNF,CCL5,VEGFA |
| GO:0006006 | glucose metabolic process | 4 | 116 | 1.07 | APOD,PGAM1,PC,ENO2 |
| GO:0007267 | cell-cell signaling | 11 | 1145 | 0.52 | MYOC,PSMA4,CCL22,GDF15,THY1,NOS2,MAPT,MBP,BDNF,PGF,CCL5 |
| GO:0002696 | positive regulation of leukocyte activation | 6 | 332 | 0.79 | TGFB1,THY1,LILRB1,PLA2G4A,NPPA,CCL5 |
| GO:0048699 | generation of neurons | 13 | 1551 | 0.46 | MYOC,TGFB1,CDH2,SOD1,THY1,AIFM1,BSG,MAPT,APOD,SPTAN1,EPHA10,BDNF,VEGFA |
| GO:0006527 | arginine catabolic process | 2 | 9 | 1.88 | NOS3,NOS2 |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5 | 216 | 0.9 | AIFM1,MAPT,MMP9,CD44,VEGFA |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 3 | 49 | 1.32 | CEACAM6,CDH2,SELE |
| GO:0045776 | negative regulation of blood pressure | 3 | 49 | 1.32 | NOS3,NOS2,NPPA |
| GO:0009991 | response to extracellular stimulus | 7 | 483 | 0.7 | GDF15,AIFM1,ALB,CST3,GSTP1,MYOCD,NUCB2 |
| GO:0048678 | response to axon injury | 3 | 51 | 1.31 | SOD1,APOD,CST3 |
| GO:0050920 | regulation of chemotaxis | 5 | 223 | 0.89 | TGFB1,GSTP1,PGF,CCL5,VEGFA |
| GO:0014745 | negative regulation of muscle adaptation | 2 | 10 | 1.84 | NOS3,MLIP |
| GO:0016043 | cellular component organization | 28 | 5447 | 0.25 | MYOC,TGFB1,TTR,CDH2,SOD1,EIF2D,THY1,AIFM1,ALB,NOS3,CLU,NOS2,BSG,MAPT,APOD,HTT,MMP9,SPTAN1,EPHA10,NAIF1,OPTN,MBP,CST3,TF,CD44,MYOCD,BDNF,VEGFA |
| GO:0031284 | positive regulation of guanylate cyclase activity | 2 | 10 | 1.84 | NOS3,NOS2 |
| GO:1900122 | positive regulation of receptor binding | 2 | 10 | 1.84 | MMP9,BDNF |
| GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 3 | 52 | 1.3 | MMP9,GSTP1,MYOCD |
| GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 5 | 228 | 0.88 | THY1,LILRB1,SELE,CD44,CCL5 |
| GO:0050918 | positive chemotaxis | 3 | 53 | 1.29 | PGF,CCL5,VEGFA |
| GO:0090257 | regulation of muscle system process | 5 | 231 | 0.87 | SOD1,NOS3,NPPA,MYOCD,MLIP |
| GO:0022604 | regulation of cell morphogenesis | 7 | 498 | 0.68 | MYOC,CDH2,THY1,MAPT,CD44,BDNF,VEGFA |
| GO:0048642 | negative regulation of skeletal muscle tissue development | 2 | 11 | 1.8 | TGFB1,MYOCD |
| GO:0043065 | positive regulation of apoptotic process | 8 | 660 | 0.62 | SOD1,AIFM1,CLU,LILRB1,MAPT,HTT,MMP9,CCL5 |
| GO:0006469 | negative regulation of protein kinase activity | 5 | 236 | 0.86 | THY1,DUSP2,NPPA,GSTP1,MYOCD |
| GO:0007159 | leukocyte cell-cell adhesion | 3 | 56 | 1.26 | SELE,CD44,CCL5 |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | 3 | 56 | 1.26 | TGFB1,NOS3,VEGFA |
| GO:0098609 | cell-cell adhesion | 7 | 505 | 0.68 | CEACAM6,CDH2,THY1,SELE,BSG,CD44,CCL5 |
| GO:0010830 | regulation of myotube differentiation | 3 | 57 | 1.26 | GDF15,MYOCD,BDNF |
| GO:0032102 | negative regulation of response to external stimulus | 6 | 367 | 0.75 | SOD1,NOS3,LILRB1,APOD,GSTP1,NUCB2 |
| GO:0032103 | positive regulation of response to external stimulus | 7 | 511 | 0.67 | PSMA4,TGFB1,NPPA,OPTN,PGF,CCL5,VEGFA |
| GO:0071901 | negative regulation of protein serine/threonine kinase activity | 4 | 136 | 1 | DUSP2,NPPA,GSTP1,MYOCD |
| GO:0000165 | MAPK cascade | 6 | 370 | 0.75 | PSMA4,TGFB1,SPTAN1,MBP,TF,CCL5 |
| GO:0032787 | monocarboxylic acid metabolic process | 7 | 515 | 0.67 | BSG,PLA2G4A,PGAM1,PTGDS,PC,GSTP1,ENO2 |
| GO:0090066 | regulation of anatomical structure size | 7 | 516 | 0.67 | SOD1,NOS3,MAPT,SPTAN1,NPPA,BDNF,VEGFA |
| GO:0002040 | sprouting angiogenesis | 3 | 59 | 1.24 | EPHB4,PGF,VEGFA |
| GO:0009894 | regulation of catabolic process | 10 | 1038 | 0.52 | PSMA4,TRIM21,AIFM1,CLU,NOS2,MAPT,HTT,PGAM1,OPTN,CST3 |
| GO:0043388 | positive regulation of DNA binding | 3 | 59 | 1.24 | TGFB1,MMP9,MYOCD |
| GO:0051155 | positive regulation of striated muscle cell differentiation | 3 | 59 | 1.24 | TGFB1,GDF15,MYOCD |
| GO:0060395 | SMAD protein signal transduction | 3 | 59 | 1.24 | TGFB1,GDF15,TF |
| GO:2000026 | regulation of multicellular organismal development | 15 | 2096 | 0.39 | PSMA4,TGFB1,CHI3L1,CDH2,SOD1,THY1,NOS3,LILRB1,MAPT,MMP9,MBP,MYOCD,BDNF,PGF,VEGFA |
| GO:0032147 | activation of protein kinase activity | 6 | 376 | 0.74 | GDF15,CHI3L1,SOD1,TF,CCL5,VEGFA |
| GO:0033993 | response to lipid | 9 | 858 | 0.56 | TGFB1,AIFM1,NOS3,LILRB1,NOS2,SELE,CST3,GSTP1,CCL5 |
| GO:0006809 | nitric oxide biosynthetic process | 2 | 13 | 1.72 | NOS3,NOS2 |
| GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway | 2 | 13 | 1.72 | APOD,MYOCD |
| GO:0019430 | removal of superoxide radicals | 2 | 13 | 1.72 | SOD1,NOS3 |
| GO:0032355 | response to estradiol | 4 | 142 | 0.99 | TGFB1,AIFM1,CST3,GSTP1 |
| GO:0071396 | cellular response to lipid | 7 | 528 | 0.66 | TGFB1,AIFM1,NOS3,LILRB1,NOS2,GSTP1,CCL5 |
| GO:0002694 | regulation of leukocyte activation | 7 | 530 | 0.66 | TGFB1,SOD1,THY1,LILRB1,PLA2G4A,NPPA,CCL5 |
| GO:0010518 | positive regulation of phospholipase activity | 3 | 62 | 1.22 | SELE,BDNF,CCL5 |
| GO:0014910 | regulation of smooth muscle cell migration | 3 | 62 | 1.22 | GSTP1,MYOCD,CCL5 |
| GO:1903902 | positive regulation of viral life cycle | 3 | 62 | 1.22 | TRIM21,PC,CCL5 |
| GO:0009611 | response to wounding | 7 | 532 | 0.65 | TGFB1,SOD1,APOD,ADORA3,CST3,CD44,VEGFA |
| GO:0043269 | regulation of ion transport | 8 | 696 | 0.6 | THY1,NOS3,LILRB1,HTT,MMP9,NPPA,TF,CCL5 |
| GO:0031329 | regulation of cellular catabolic process | 9 | 875 | 0.55 | PSMA4,TRIM21,AIFM1,CLU,MAPT,HTT,PGAM1,OPTN,CST3 |
| GO:0044237 | cellular metabolic process | 34 | 7513 | 0.19 | PSMA4,TGFB1,TTR,TRIM21,ABCB6,CDH2,SOD1,EIF2D,THY1,DUSP2,ALB,NOS3,CLU,LILRB1,NOS2,BSG,MAPT,EPHB4,PLA2G4A,PGAM1,PTGDS,SPTAN1,EPHA10,NPPA,HSPA14,OPTN,PC,MBP,CST3,GSTP1,TF,CD44,ENO2,CCL5 |
| GO:0010634 | positive regulation of epithelial cell migration | 4 | 147 | 0.97 | TGFB1,NOS3,MMP9,VEGFA |
| GO:0035886 | vascular associated smooth muscle cell differentiation | 2 | 14 | 1.69 | MYOCD,VEGFA |
| GO:0043508 | negative regulation of JUN kinase activity | 2 | 14 | 1.69 | NPPA,GSTP1 |
| GO:0050921 | positive regulation of chemotaxis | 4 | 147 | 0.97 | TGFB1,PGF,CCL5,VEGFA |
| GO:0048646 | anatomical structure formation involved in morphogenesis | 9 | 883 | 0.54 | TGFB1,THY1,DUSP2,NOS3,APOD,EPHB4,MMP9,PGF,VEGFA |
| GO:0016310 | phosphorylation | 11 | 1275 | 0.47 | PSMA4,TGFB1,THY1,EPHB4,PGAM1,SPTAN1,EPHA10,MBP,TF,ENO2,CCL5 |
| GO:0008015 | blood circulation | 6 | 394 | 0.72 | TGFB1,SOD1,NOS3,NOS2,NPPA,VEGFA |
| GO:0006879 | cellular iron ion homeostasis | 3 | 66 | 1.19 | ABCB6,SOD1,TF |
| GO:0022617 | extracellular matrix disassembly | 3 | 66 | 1.19 | BSG,MMP9,CD44 |
| GO:0006026 | aminoglycan catabolic process | 3 | 67 | 1.19 | TGFB1,CHI3L1,CD44 |
| GO:0010935 | regulation of macrophage cytokine production | 2 | 15 | 1.66 | TGFB1,LILRB1 |
| GO:0043406 | positive regulation of MAP kinase activity | 5 | 265 | 0.81 | TGFB1,GDF15,SOD1,TF,VEGFA |
| GO:0043542 | endothelial cell migration | 3 | 67 | 1.19 | NOS3,EPHB4,VEGFA |
| GO:0050930 | induction of positive chemotaxis | 2 | 15 | 1.66 | PGF,VEGFA |
| GO:0008219 | cell death | 10 | 1091 | 0.5 | CEACAM6,TGFB1,CHI3L1,AIFM1,CLU,HTT,NAIF1,OPTN,CST3,CASP14 |
| HSA-109582 | Hemostasis | 13 | 605 | 0.87 | CEACAM6,TGFB1,SOD1,ALB,NOS3,CLU,NOS2,SELE,BSG,PLA2G4A,TF,CD44,VEGFA |
| HSA-168256 | Immune System | 20 | 1956 | 0.55 | PSMA4,CEACAM6,CCL22,TGFB1,TTR,TRIM21,CHI3L1,SOD1,NOS3,CLU,LILRB1,NOS2,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44,CCL5,VEGFA |
| HSA-168249 | Innate Immune System | 14 | 1025 | 0.67 | PSMA4,CEACAM6,TTR,TRIM21,CHI3L1,NOS3,CLU,NOS2,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44 |
| HSA-114608 | Platelet degranulation | 6 | 127 | 1.21 | TGFB1,SOD1,ALB,CLU,TF,VEGFA |
| HSA-6798695 | Neutrophil degranulation | 9 | 473 | 0.82 | CEACAM6,TTR,CHI3L1,PGAM1,MMP9,SPTAN1,CST3,GSTP1,CD44 |
| HSA-76002 | Platelet activation, signaling and aggregation | 7 | 260 | 0.97 | TGFB1,SOD1,ALB,CLU,PLA2G4A,TF,VEGFA |
| HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5 | 107 | 1.21 | CCL22,TGFB1,NOS2,MMP9,VEGFA |