Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Relative Telomere Length (RTL)
Category	Molecular Changes
Affected targets	Cardiac Aging
Hallmarks	Cellular Senescence
Molecular	DNA
Description	With each replicative cell division, telomeres will shorten, and this process has been correlated with cellular senescence. In addition to that, telomere shortening can be accelerated in the setting of disease conditions characterized by increased inflammation, which makes it a measurable marker of inflammation and oxidative stress.
EXPERIMENT INFORMATION
Region	Lebanon
Race	multiple racial
Samples	502
Age	18(over)
Gender	/
Application	Predictive
Conclusion	Higher c-peptide level contributes to telomere shortening over time, suggesting that metabolic dysregulation may play a role in early aging. further understanding of this relationship and addressing high c-peptide levels can be important to prevent premature aging.
Reference	Mona P. Nasrallah, Front Endocrinol (Lausanne)., 2022
Details	PMID:36060975 (Click to Pubmed) ； IF: ； Citation:
Confidence