Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Mitochondria
Category	Molecular Changes
Affected targets	Hematopietic System Aging
Hallmarks	Mitochondrial Dysfunction
Molecular	DNA
Description	Mitochondria are organelles responsible for the generation of most of the chemical energy of cells. They have their own DNA and RNA, as well as a complete system of transcription and translation, allowing them to synthesize some of their own proteins.
EXPERIMENT INFORMATION
Region	Brazil
Race	multiple racial
Samples	39/21
Age	64.5/64.0/66.0
Gender	17/43
Application	Functional
Conclusion	No correlation was found between age and mtdna-cn, but a direct correlation was observed for cases with mtdna-cn >1000 (r = 0.41). the mtdna-cn >1000 group had greater tissue autofluorescence and higher body mass index compared to the mtdna-cn <1000 group (bmi; 25.7 vs 22.0 kg/m2, respectively). mtdna-cn correlated with tissue autofluorescence in the overall sample (r = 0.55) and in the t2d group (r = 0.64). pink and prkn expressions were inversely correlated with age. mitochondriogenesis genes and txnip expressions were higher in the t2d group, and correlations among the mitochondriogenesis genes were also stronger in this group, relative to the subgroup with mtdna-cn >1000.
Reference	Suely Kazue Nagahashi Marie, Exp Gerontol., 2022
Details	PMID:35995312 (Click to Pubmed) ； IF: ； Citation:
Confidence