Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Fecal Pancreatic Elastase-1
Category	Molecular Changes
Affected targets	Pancreatic Aging
Hallmarks	Other
Molecular	Protein
Description	The structural changes occurring in the pancreas as a part of the natural aging process include patchy fibrosis, lipomatosis, ductal epithelial hyperplasia, ductal widening and intraluminal protein deposition which have been documented in postmortem studies. With aging, also the incidence of maldigestive symptoms and malnutrition increases, raising the possibility that these might be caused at least in part by inadequate pancreatic enzyme secretion due to degenerative processes and damage of the gland.
EXPERIMENT INFORMATION
Region	Finland
Race	white
Samples	159
Age	60-92
Gender	/
Application	Predictive
Conclusion	Among older individuals without any known gastrointestinal disease, surgery or diabetes mellitus, one fifth of the individuals had abnormal fecal elastase-1 levels indicating pancreatic exocrine insufficiency. in the general unselected population with a high incidence of diabetes mellitus, malabsorption syndromes and abdominal surgery the incidence might be even higher. it is important to increase the awareness of these problems in this population group among general physicians since for these patients, careful clinical examination and possibly pancreatic enzyme replacement therapy are warranted.
Reference	Jaroslaw Walkowiak, BMC Geriatr, 2011
Details	PMID:21266058 (Click to Pubmed) ； IF: ； Citation:
Confidence