Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Serum Alanine Aminotransferase (ALT)
Category	Molecular Changes
Affected targets	Liver Aging
Hallmarks	Genomic Instability
Molecular	Protein
Description	Serum alanine aminotransferase (ALT) level is frequently used as a surrogate marker for hepatocyte injury. Normal ranges vary according to the commercial kit used, but have historically been set at around 40 IU/L.
EXPERIMENT INFORMATION
Region	USA
Race	white
Samples	2364
Age	30-62/63-71/72-77/78-93
Gender	1044/1320
Application	Predictive
Conclusion	Alt levels decrease with age in both men and women independent of metabolic syndrome components, adiposity signaling biomarkers, and other commonly used liver function tests. further studies are needed to understand the mechanisms responsible for a decline in alt with age, and to establish the optimal cut-point of normal alt in the elderly.
Reference	Rohit Loomba, PLoS One, 2010
Details	PMID:21170382 (Click to Pubmed) ； IF: ； Citation:
Confidence