Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Alanine Aminotransferase
Category	Molecular Changes
Affected targets	Liver Aging
Hallmarks	Loss of Proteostasis
Molecular	Protein
Description	One of the key clinical markers of fatty liver is raised blood activity of alanine transaminase (ALT), which is an enzyme released from damaged hepatocytes
EXPERIMENT INFORMATION
Region	Australia
Race	white
Samples	1673
Age	70-97
Gender	1673/0
Application	Functional
Conclusion	In conclusion, low circulating alt activity was found to be associated with aging and frailty in old men and to be a predictor of their subsequent survival.? the effect of alt on mortality was mediated via its association with frailty and aging.? alt may be a useful biomarker for aging and frailty and should be considered for future studies, especially because the decrease in alt with age and frailty was greater than that seen with albumin.
Reference	Robert G. Cumming, J Gerontol A Biol Sci Med Sci, 2010
Details	PMID:20498223 (Click to Pubmed) ； IF: ； Citation:
Confidence