Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Apolipoprotein E (APOE) ε4
Category	Molecular Changes
Affected targets	Brain Aging
Hallmarks	Loss of Proteostasis
Molecular	DNA
Description	Apolipoprotein E (APOE) ε4, the strongest genetic risk factor for late onset Alzheimer's disease (LOAD), has been associated with cognitive decline independent from AD pathology.
EXPERIMENT INFORMATION
Region	UK
Race	multiple racial
Samples	500000
Age	40-70
Gender	/
Application	Predictive
Conclusion	While prs-load including all variants (except apoe) predicted cognitive level, apoe ε4 and prs-load based on 17 non-apoe gene variants with strong association to ad (p < 5e-8) predicted age-related decline in verbal numeric reasoning. the effect on decline were partly driven by 4 variants involved in the immune system. those variants also predicted serum levels of the inflammatory marker c-reactive protein (crp), but crp did not mediate the effect on decline. those findings suggest genetic variations in immune functions play a role in aspects of cognitive aging that may be independent of load pathology as well as systemic inflammation measured by crp.
Reference	Adil?Supiyev, Neurobiology of Aging, 2023
Details	PMID:36965205 (Click to Pubmed) ； IF: ； Citation:
Confidence