The detail information of "CD8+ T cells"

BIOMARKER INFORMATION
Biomarker
CD8+ T cells
Category
Cellular Alterations
Affected targets
Immune System Aging
Hallmarks
Cellular Senescence
Molecular
Other
Description
The CD8?T-cell population loses proper responsiveness at old age
EXPERIMENT INFORMATION
Region
Netherlands(Northern Netherlands)
Race
white
Samples
50(symptomatic)/15(symptomatic)
Age
21-82/63-83
Gender
/
Application
Predictive
Conclusion
Together, our study indicates that co-expression of tigit and helios provides a novel useful marker to better define immunosenescent cd8?t cells. moreover, we show that these cells already accumulate in the intermediate-differentiation stage in older individuals. these findings challenge the current dogma of late-differentiation stage as a sole proxy for t-cell immunosenescence. these insights may refine future interpretation of studies on impaired cd8?t-cell mediated immunity to viral infections at old age.++.
Reference
Teun Guichelaar, Front Immunol, 2022
Details
PMID:35651622 (Click to Pubmed) ； IF: ； Citation:
Confidence

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