The detail information of "Relative Telomere Length (RTL)"

BIOMARKER INFORMATION
Biomarker
Relative Telomere Length (RTL)
Category
Molecular Changes
Affected targets
Skin Aging
Hallmarks
Telomere Attrition
Molecular
Other
Description
Relative telomere length (RTL) is a biomarker for physiological aging
EXPERIMENT INFORMATION
Region
worldwide
Race
multiple racial
Samples
2262(627(AMD)/1635(without AMD))
Age
70-95
Gender
1077/1185
Application
Functional
Conclusion
In this study, we found an association between shorter rtl and amd in an elderly population independent from potential risk factors. this association was present only in women and not in men, driven by biological age and to some extent independent from chronological age. our results are in line with a sex-differential pathway from oxidative stress to amd. further studies on the progression of the disease including follow-up data are required for a better understanding of the pathomechanisms of amd.
Reference
Florian Kronenberg, Invest Ophthalmol Vis Sci, 2022
Details
PMID:35612837 (Click to Pubmed) ； IF: ； Citation:
Confidence

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