Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Advanced Glycation End-products (AGEs)
Category	Molecular Changes
Affected targets	Skeletal Muscle Aging
Hallmarks	Epigenetic Alterations
Molecular	Protein
Description	Advanced glycation end-products (AGEs) are end products of protein glycation that bind to the receptor for AGEs (RAGE) and activate nicotinamide adenine dinucleotide phosphate oxidase (NOX), resulting in increased oxidative stress and rotator cuff fragility.
EXPERIMENT INFORMATION
Region	Asia
Race	yellow
Samples	12
Age	62.3
Gender	/
Application	Functional
Conclusion	Stump classification type 3 exhibited the highest accumulation of ages and the highest oxidative stress and apoptosis, suggesting a high degree of degeneration and inflammation. imaging based on stump classification reflects the degeneration and fragility of the torn rotator cuff site.
Reference	Ryosuke Kuroda, Am J Sports Med, 2022
Details	PMID:35486520 (Click to Pubmed) ； IF: ； Citation:
Confidence