Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Polychlorinated Biphenyls (PCBs) and Dioxins
Category	Molecular Changes
Affected targets	Immune System Aging
Hallmarks	Genomic Instability
Molecular	Other
Description	Recent studies showed that PCBs are likely to regulate telomere length and telomerase activity. Whereas six population-based studies showed that serum levels of POPs were associated with longer telomeres , several studies showed shorter TL associated with POPs when they were analyzed in immortal human skin keratinocyte (HaCaT) cells and undifferentiated human myeloblastic/promyelocytic leukemia cell line (HL-60) . Moreover, an inverse association between COPs and LT in lymphocytes and buccal cells was found.
EXPERIMENT INFORMATION
Region	Europe
Race	/
Samples	886
Age	67.7±6.1
Gender	/
Application	Predictive
Conclusion	This cross-sectional study of individuals over 55 years showed that dietary exposure to total pcbs and dl-pcbs alone and together with dioxins were associated with tl. however, dietary dioxins exposure was not found to have association with tl. further research studies, preferably with pops measured in biological samples, are needed to confirm these observations using larger longitudinal studies with repeated measures of tl.
Reference	Amelia Marti, Nutrients, 2022
Details	PMID:35057533 (Click to Pubmed) ； IF: ； Citation:
Confidence