Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Magnetic Resonance Imaging (MRI)
Category	Imaging Traits
Affected targets	Brain Aging
Hallmarks	Deregulated Nutrient Sensing
Molecular	Other
Description	A common observation in fMRI studies using the BOLD signal is that older adults, compared with young adults, show overactivations, particularly during less demanding tasks.
EXPERIMENT INFORMATION
Region	Sweden
Race	multiple racial
Samples	57
Age	71.09/25.2
Gender	45545
Application	Functional
Conclusion	Findings of increased fmri activations in older compared with younger adults have been suggested to reflect increased use of neuronal resources to cope with reduced brain function. comparing fmri and simultaneously acquired functional positron emission tomography as an alternative index of synaptic activity, we show that age-related overactivations do not appear to be neuronal in origin. this result is important because mechanisms underlying compensatory processes in aging are potential targets for interventions aiming to prevent age-related cognitive decline.
Reference	Lars Stiernman, Journal of Neuroscience, 2023
Details	PMID:36868855 (Click to Pubmed) ； IF: ； Citation:
Confidence