Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Myeloid-derived suppressor cells (MDSCs)
Category	Cellular Alterations
Affected targets	Immune System Aging
Hallmarks	Stem Cell Exhaustion
Molecular	Other
Description	Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid precursor cells that function as negative regulators of immune responses by inhibiting T cell proliferation, IFN-gamma production, and CTL induction and have been reported to play important roles in the development of microbial inflammation and infection
EXPERIMENT INFORMATION
Region	/
Race	white
Samples	57
Age	18-92
Gender	26/31
Application	Functional
Conclusion	Collectively, our data demonstrate that a detrimental cross-talk occurs in elders' bm, resulting in the induction of suppression in i-mdscs and adipogenesis in bm-mscs, most likely induced or maintained by both cell–cell contacts and il-6. these results open up new possibilities for defining markers and targets for preventive or therapeutic strategies in aging to eventually regulate immunity, inflammation, and bone resorption in elders.
Reference	Maria Elisa Perico, Cells, 2022
Details	PMID:35011569 (Click to Pubmed) ； IF: ； Citation:
Confidence