The detail information of "Myogenic and Stress Factors in Skeletal Muscle"

BIOMARKER INFORMATION
Biomarker
Myogenic and Stress Factors in Skeletal Muscle
Category
Molecular Changes
Affected targets
Skeletal Muscle Aging
Hallmarks
Altered Intercellular Communication
Molecular
Other
Description
Most studies that aimed to unravel the signaling pathways responsible for age-related sarcopenia compared the muscle expression profile between young and old animals or humans. However, an important limitation of this approach is that no distinction is made between old muscle with normal functioning and old muscle suffering from impaired functionality or strength, as is the case in sarcopenia. Furthermore, the few reports that compared sarcopenic to nonsarcopenic older adults? made use of the outdated EWGSOP definition , in which muscle mass and not muscle strength was the primary criterion of sarcopenia .
EXPERIMENT INFORMATION
Region
/
Race
white
Samples
24(11/13)
Age
74.47±5.06
Gender
45579
Application
Predictive
Conclusion
To conclude, the present study shows that the muscle expression profile of older adults (65–86 years) with lms is characterized by a higher stress-related (ie, chop and p-erk1/2) and myogenic (ie, pax7, myod, and desmin) signaling, whereas inflammation (ie, p-p65nf-κb) was lower and muscle catabolism was not different from older adults with pms. these data provide novel indications on the molecular networks behind the progression of age-related sarcopenia. an upregulation of myogenic factors, which might be related to increased p-erk1/2 and/or decreased p-p65nf-κb expression, seems to be involved in age-related loss of muscle strength. yet, longitudinal evidence is required to determine whether changes in myogenic factors precede or respond to muscle strength loss,? to provide a more detailed view on the changes during the progression of the sarcopenic muscle phenotype, and to eventually investigate whether modulation of myogenic expression affects the clinical muscle phenotype (eg, strength).
Reference
Katrien Koppo, PhD, J Gerontol A Biol Sci Med Sci, 2022
Details
PMID:34984449 (Click to Pubmed) ； IF: ； Citation:
Confidence

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