Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	HIV-1 Reservoir
Category	Molecular Changes
Affected targets	Immune System Aging
Hallmarks	Telomere Attrition
Molecular	DNA
Description	Persistence of HIV-1, causing chronic immune activation, is a key determinant of premature senescence. HIV-1 positive children display higher percentages of activated and senescent CD8 cells, which inversely correlate with telomere length, thus supporting the link between biological ageing and immunosenescence.
EXPERIMENT INFORMATION
Region	Europe
Race	multiple racial
Samples	37
Age	13.8(9-16.7)
Gender	45651
Application	Functional
Conclusion	This study investigates for the first time the association between hiv-1 reservoir and telomere shortening, thymic output and immunosenescence in a unique cohort of long-term virally suppressed adolescents who initiated art early in life. we show that early art initiation restricts the size of viral reservoir and prevents premature immunosenescence and telomere shortening. timing of art initiation in infancy is crucial and has long-term consequences on the immune and biological ageing profile.
Reference	Paolo Rossi, Anita De Rossi, J Int AIDS Soc., 2021
Details	PMID:34797948 (Click to Pubmed) ； IF: ； Citation:
Confidence