| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
p16INK4a |
Category |
Molecular Changes |
Affected targets |
Kidney Aging |
Hallmarks |
Cellular Senescence |
Molecular |
Protein |
Description |
We enumerated the number of cells positive for P16(ink4a)protein, a marker of cellular senescence, by immunohistochemistry followed by digital quantification, on renal biopsies from 40 patients with active LN. |
| EXPERIMENT INFORMATION | |
Region |
Belgium |
Race |
multiple racial |
Samples |
31/9 |
Age |
/ |
Gender |
/ |
Application |
Functional |
Conclusion |
We demonstrate, for the first time, that ln biopsies characterised by renal impairment display increased P16(ink4a)-positive cells, associated with higher fibrosis and cd8+t cell infiltration. |
Reference |
Nisha Limaye, RMD Open, 2021 |
Details |
PMID:34686545 (Click to Pubmed) ； IF: ； Citation: |
Confidence |