Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	MicroRNA-200 family
Category	Molecular Changes
Affected targets	Instestinal Aging
Hallmarks	Cellular Senescence
Molecular	DNA
Description	Genetic deletion of all miR-200s in the human GC cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated beta-galactosidase (SA-beta-gal) activity, and aberrant metabolism, collectively resembling the senescent phenotype.
EXPERIMENT INFORMATION
Region	worldwide
Race	multiple racial
Samples	/
Age	/
Gender	/
Application	Functional
Conclusion	Our work has identified a new role of mir-200 family members which function as an integrated unit serving to link senescence with emt, two major conserved biological processes.
Reference	Jikun Li, Oncogene, 2022
Details	PMID:34667277 (Click to Pubmed) ； IF: ； Citation:
Confidence