Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Grip Strength
Category	Physiological Characteristics
Affected targets	Skeletal Muscle Aging
Hallmarks	Loss of Proteostasis
Molecular	Other
Description	Grip strength is an overall indicator of general health status and an indicator of many specific health outcomes including cognition. Grip strength is a reliable marker of aging across the life course and predicts mortality and disability.
EXPERIMENT INFORMATION
Region	UK
Race	multiple racial
Samples	27093
Age	67/67/68/71
Gender	12139/14954
Application	Functional
Conclusion	We conclude that as the population ages, grip strength declines at a systematic and predictable rate equal to ?0.40 kg per year (approximately ?0.50 kg for men and ?0.30 kg for women) in residents of england aged 50 and older. age effects were predominant and most consistent across methodologies. while there was some evidence for cohort effects, such effects were minimal and therefore indicative that grip strength is a consistent physiological biomarker of aging.
Reference	Patrick O'Keefe, J Gerontol A Biol Sci Med Sci., 2022
Details	PMID:34244743 (Click to Pubmed) ； IF: ； Citation:
Confidence