Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Cyclin-dependent Kinase Inhibitor 2A
Category	Cellular Alterations
Affected targets	Hematopietic System Aging
Hallmarks	Cellular Senescence
Molecular	RNA
Description	Cyclin-dependent kinase inhibitor 2A (CDKN2A), a major tumor suppressor gene, is located at chromosome 9p21 in a region that has frequent loss of heterozygosity in several types of tumors and encodes the CDKN2A protein. This protein typically blocks abnormal cell proliferation and growth by inhibiting the ability of cyclin-dependent kinases (CDKs) 4 and 6 to accelerate cell cycle G1 phase progression. Because CDKN2A is considered to be an important gene in cellular senescence and aging, it is utilized as a molecular marker of cellular senescence.
EXPERIMENT INFORMATION
Region	Japan
Race	yellow
Samples	45
Age	44.53±14.5
Gender	45293
Application	Predictive
Conclusion	The results of the present study demonstrated that cdkn2a mrna expression in blood was lower in patients with ad, compared with healthy controls, but it was unchanged in patients with other neurodegenerative diseases. although cdkn2a mrna levels in blood may be a biomarker for differentiating ad from other neurodegenerative diseases, further research with a larger sample size is needed to elucidate the relationships between cdkn2a gene expression in blood and the development of other neurodegenerative diseases.
Reference	Jun-Ichi Iga, J Alzheimers Dis., 2021
Details	PMID:34219731 (Click to Pubmed) ； IF: ； Citation:
Confidence