The detail information of "DNAmFitAge"

BIOMARKER INFORMATION
Biomarker
DNAmFitAge
Category
Molecular Changes
Affected targets
Whole Body
Hallmarks
Epigenetic Alterations
Molecular
DNA
Description
We then use these DNAm fitness biomarkers to develop the novel DNAm fitness-related biological age indicator, DNAmFitAge, which quantifies the relationship between physical fitness and biological aging processes. This novel measure incorporates mortality risk with strength, mobility, and cardiovascular fitness using blood DNAm biomarkers. Our newly constructed DNAm biomarkers and DNAmFitAge provide researchers and physicians a new method to incorporate physical fitness into epigenetic clocks and emphasizes the effect lifestyle has on the aging methylome.
EXPERIMENT INFORMATION
Region
worldwide
Race
multiple racial
Samples
/
Age
/
Gender
/
Application
Predictive
Conclusion
Overall, dnamgaitspeed, dnamgripmax, dnamfev1, dnamvo2max, and dnamfitage provide epigenetic components to evaluating a person's physical fitness. physically fit people have a younger dnamfitage and younger fitageacceleration, and younger values are associated with more physical activity and better age-related outcomes. our research suggests exercise and stronger fitness parameters are protective to dnamfitage in both sexes. we expect dnamfitage will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions.
Reference
Steve Horvath, Aging (Albany NY), 2023
Details
PMID:36812475 (Click to Pubmed) ； IF: ； Citation:
Confidence

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