Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Epigenetic Clocks
Category	Molecular Changes
Affected targets	Whole Body
Hallmarks	Epigenetic Alterations
Molecular	Other
Description	Epigenetic "clocks" are estimations of "biological" age derived from DNAm patterns associated with markers of aging?. Initially, these measures, more generally called DNAm surrogates, were developed by identifying DNAm patterns associated with chronological age, such as the Horvath and Hannum clocks?. More recent epigenetic measures, known as the "second and third generation clocks," focus on DNAm patterns associated with aging phenotypes, health risks, mortality, or change in health indicators, including GrimAge, PhenoAge and DunedinPACE?.
EXPERIMENT INFORMATION
Region	worldwide
Race	multiple racial
Samples	3581
Age	68.25
Gender	/
Application	Predictive
Conclusion	Pc-based epigenetic age acceleration measures do not significantly change the relationship of dnam-based age acceleration measures to health outcomes or mortality compared to earlier versions of these measures. while the usefulness of dnam-based age acceleration as a predictor of later life health outcomes is quite clear, other factors such as demographics, ses, mental health, and health behaviors remain equally, if not more robust, predictors of later life outcomes.
Reference	Eileen M Crimmins, Proc Natl Acad Sci U S A, 2023
Details	PMID:36802439 (Click to Pubmed) ； IF: ； Citation:
Confidence