Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Lipid Oxidation Products
Category	Molecular Changes
Affected targets	Reproductive System Aging
Hallmarks	Altered Intercellular Communication
Molecular	Other
Description	By contrast, lipid components of the SASP are understudied. We show that senescent cells activate the biosynthesis of several oxylipins that promote segments of the SASP and reinforce the proliferative arrest. Notably, senescent cells synthesize and accumulate an unstudied intracellular prostaglandin, 1a,1b-dihomo-15-deoxy-delta-12,14-prostaglandin J2. Released 15-deoxy-delta-12,14-prostaglandin J2 is a biomarker of senolysis in culture and in vivo.
EXPERIMENT INFORMATION
Region	Europe
Race	multiple racial
Samples	/
Age	/
Gender	/
Application	Functional
Conclusion	These data identify an important aspect of cellular senescence and a method to detect senolysis.
Reference	Christopher D Wiley, Cell Metab, 2021
Details	PMID:33811820 (Click to Pubmed) ； IF: ； Citation:
Confidence