The detail information of "Transforming Growth Factor Beta (TGF-β)"

BIOMARKER INFORMATION
Biomarker
Transforming Growth Factor Beta (TGF-β)
Category
Cellular Alterations
Affected targets
Pancreatic Aging
Hallmarks
Stem Cell Exhaustion
Molecular
Other
Description
Epithelial-mesenchymal transition (EMT) is a plausible mechanism of SCP tumorigenesis [4]. In addition, transforming growth factor-beta (TGF-beta) is known to induce EMT [5, 6].
EXPERIMENT INFORMATION
Region
Japan
Race
multiple racial
Samples
3
Age
/
Gender
/
Application
Functional
Conclusion
The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.
Reference
Takanori Goi, World journal of surgical oncology, 2021
Details
PMID:33726729 (Click to Pubmed) ； IF: ； Citation:
Confidence

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