Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Dual-parameter recognition fluorescent probe
Category	Others
Affected targets	Whole Body
Hallmarks	Cellular Senescence
Molecular	Other
Description	This probe remains silent in non-senescent cells, yet produces bright fluorescence after sequential responses to two senescence-associated markers, namely, SA-beta-gal and MAO-A. In-depth studies reveal that this probe allows for high-contrast imaging of senescence, independent of the cell source or stress type. More impressively, such dual-parameter recognition design further allows it to distinguish senescence-associated SA-beta-gal/MAO-A from cancer-related β-gal/MAO-A, compared to commercial or previous single-marker detection probes.
EXPERIMENT INFORMATION
Region	China
Race	yellow
Samples	/
Age	/
Gender	/
Application	Predictive
Conclusion	This study offers a valuable molecular tool for imaging cellular senescence, which is expected to significantly expand the basic studies on senescence and facilitate advances of senescence-related disease theranostics.
Reference	Weihong Tan, Anal Chem, 2023
Details	PMID:36795559 (Click to Pubmed) ； IF: ； Citation:
Confidence