Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	MTS1 (Multiple Tumor Suppressor 1)
Category	Cellular Alterations
Affected targets	Lung Aging
Hallmarks	Cellular Senescence
Molecular	Other
Description	We observed that the senescent marker p16 is predominantly localized to bronchiolized epithelial structures in scarred regions of IPF and systemic sclerosis-associated interstitial lung disease (SSc-ILD) lung tissue, overlapping with the basal epithelial markers Keratin 5 and Keratin 17.
EXPERIMENT INFORMATION
Region	USA
Race	multiple racial
Samples	/
Age	/
Gender	/
Application	Functional
Conclusion	We identified a population of basal epithelial cells defined by, and enriched for, markers of cellular senescence and identified candidate markers specific to senescent basal epithelial cells in ild that can enable future functional studies. notably, gene expression of these cells significantly overlaps with terminally differentiating cells in stratified epithelia, where it is driven by p53 activation as part of the senescence program.
Reference	Joseph R Arron, JCI insight, 2021
Details	PMID:33705361 (Click to Pubmed) ； IF: ； Citation:
Confidence