Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Nicotinamide adenine dinucleotide (NAD+)
Category	Molecular Changes
Affected targets	Whole Body
Hallmarks	Genomic Instability
Molecular	Other
Description	Aging and age-related diseases has been reported to be closely associated with age-related decline in blood and tissue nicotinamide adenine dinucleotide (NAD+) content . Moreover, preclinical studies revealed that the administration of NAD?+?-related metabolites, such as nicotinamide (NAM), nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR), reverses the aging-related decline in physiological function and prevents the onset of age-related diseases partly via the activation of NAD?+?dependent deacetylase sirtuin.
EXPERIMENT INFORMATION
Region	Japan
Race	yellow
Samples	42
Age	65-88
Gender	42/0
Application	Anti-Aging
Conclusion	We identified negative correlations between blood concentrations of na and hearing ability at 1000 and 2000?hz. nad+ metabolic pathway might be associated with arhl onset or progression. further studies are warranted.
Reference	Toshimasa Yamauchi, BMC Geriatr, 2023
Details	PMID:36792992 (Click to Pubmed) ； IF: ； Citation:
Confidence