Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	DNA Damage Response (DDR) Signals
Category	Molecular Changes
Affected targets	Hematopietic System Aging
Hallmarks	Epigenetic Alterations
Molecular	DNA
Description	DDR-associated parameters, including endogenous DNA damage (single-strand breaks and double-strand breaks (DSBs) measured by the alkaline comet assay (Olive Tail Moment (OTM); DSBs-only by γH2AX immunofluorescence staining), DSBs repair capacity, oxidative stress, and apurinic/apyrimidinic sites were evaluated in PBMCs
EXPERIMENT INFORMATION
Region	/
Race	/
Samples	243
Age	38
Gender	45612
Application	Predictive
Conclusion	Prospective studies confirming the value of dna damage accumulation as a biomarker of aging, as well as the presence of a relevant agethreshold.
Reference	Petros Psfikakis, International Journal of Molecular Sciences, 2023
Details	PMID:37108309 (Click to Pubmed) ； IF: ； Citation:
Confidence