| BIOMARKER INFORMATION | |
|---|---|
Biomarker |
DNA Methylation Age Predictor (PAYA) |
Category |
Molecular Changes |
Affected targets |
Whole Body |
Hallmarks |
Epigenetic Alterations |
Molecular |
Other |
Description |
Epigenetic age predictors are utilized to study both biological aging and in forensics. Environmental and psychological stressors affect epigenetic patterns, and the development of epigenetic age predictors assessing biological age due to environmental influences or health issues are a growing field within aging research. These predictors can, among other applications, be used to measure the effects of anti-aging interventions. |
| EXPERIMENT INFORMATION | |
Region |
Finland,UK |
Race |
multiple racial |
Samples |
2316 |
Age |
22190 |
Gender |
758/975 |
Application |
Predictive |
Conclusion |
To conclude, through thorough evaluation and selection of different analytical options, we have developed paya, the first blood based age predictor developed specifically for adolescents and young adults. we observe that paya outperforms existing epigenetic age predictors, making it eligible for application in forensic age-assessment, either alone or in combination with existing radiographic methods. future studies is required to reveal if paya is robust when applied to diverse populations with different ethnicities and environmental or genetic effects. |
Reference |
Veslem?y Rolseth, Sci Rep, 2023 |
Details |
PMID:36759656 (Click to Pubmed) ； IF: ； Citation: |
Confidence |