Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	miR-409-3p
Category	Molecular Changes
Affected targets	Whole Body
Hallmarks	Stem Cell Exhaustion
Molecular	RNA
Description	Numerous studies indicated that microRNA (miR or miRNA) is involved in post-transcriptional regulation of gene expression concerning diverse biological functions, including ageing and angiogenesis. A previous report showed that angiogenesis and tissue repair were regulated by miRNA-135a-3p via targeting p38 signalling in endothelial cells, revealing a link among miRNA, angiogenesis and endothelial cells
EXPERIMENT INFORMATION
Region	Asia
Race	yellow
Samples	57
Age	25.8±0.9/69.7±0.5
Gender	32/25
Application	Functional
Conclusion	In summary, hsa-mir-409-3p was upregulated in senescent epcs and acted as a negative modulator of angiogenesis via targeting protein phosphatase 2 catalytic subunit alpha (ppp2ca) gene and regulating pp2a/p38 signalling. data from human pbmcs suggested hsa-mir-409-3p a potential biomarker for human ageing.
Reference	Cheng-Huang Su, J Cell Mol Med, 2023
Details	PMID:36756741 (Click to Pubmed) ； IF: ； Citation:
Confidence