Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Lysophospholipids and Branched-Chain Amino Acids
Category	Cellular Alterations
Affected targets	Whole Body
Hallmarks	Mitochondrial Dysfunction
Molecular	Other
Description	LPC and LPE are important precursors for the biosynthesis of phospholipids (PLs), including phosphatidylcholine (PC) and phosphatidylethanolamine (PE), which are essential for maintaining the structure and function of biological membranes (including mitochondrial membranes). We observed that serum levels of six LPC and ten LPE were down-regulated in older adults compared to young. In the Baltimore Longitudinal Study of Aging, lower plasma LPC was correlated with impairment of mitochondrial oxidative capacity after adjusting for age, sex, and height
EXPERIMENT INFORMATION
Region	Asia
Race	yellow
Samples	32(old)/32(youth)
Age	60(over)/36-59
Gender	/
Application	Functional
Conclusion	We preliminarily revealed the metabolite changes associated with aging in chinese adults. decreases in mitochondrial membrane-related lysophospholipids and dysfunction of branched-chain amino acid metabolism were determined to be the characteristics and promising research targets for aging.
Reference	Lina Ma, Eur J Med Res, 2023
Details	PMID:36732870 (Click to Pubmed) ； IF: ； Citation:
Confidence