Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Telomere Length and Beta-Galactosidase Activity
Category	Molecular Changes
Affected targets	Lung Aging
Hallmarks	Telomere Attrition
Molecular	Other
Description	Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with age.In a prospective study, we measured TL by Flow-FISH in 70 hospitalized COVID-19 patients and compared TL distribution with our reference cohort of 491 healthy volunteers.
EXPERIMENT INFORMATION
Region	Europe
Race	multiple racial
Samples	70
Age	63
Gender	22/48
Application	Predictive
Conclusion	Lung tissue from patients with very short telomeres exhibit signs of senescence in structural and immune cells. our results suggest that tl influences the severity of the disease.
Reference	Antoine Froidure, Aging (Albany NY), 2020
Details	PMID:33104521 (Click to Pubmed) ； IF: ； Citation:
Confidence