Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Red Cell Distribution Width (RDW)
Category	Cellular Alterations
Affected targets	Skeletal Aging
Hallmarks	Genomic Instability
Molecular	Protein
Description	Participants with greater variability in red cell size were weaker, walked more slowly, and had a worse cognitive function. They were more likely to have functional limitations (35.2% in the highest RDW category vs 16.0% in the lowest, p < .001) and frailty (30.3% vs 11.3%, p < .001). Those with greater variability in red cell size were more likely to develop new functional limitations and to become frail. The risk of having 2 or more falls was also greater (highest 19.2% vs lowest 10.3%, p < .001). The risk of hospitalization was higher in those with the highest variability (odds ratio [95% confidence interval], 1.8 [1.3-2.5]) compared with the lowest. Variability in red cell size was related to total and cause-specific mortality.
EXPERIMENT INFORMATION
Region	/
Race	/
Samples	3635
Age	/
Gender	3635/0
Application	Predictive
Conclusion	Greater variability in red cell size is associated with diverse aging-related outcomes, suggesting that it may have potential value as a marker for biological aging.
Reference	/, J Gerontol A Biol Sci Med Sci, 2021
Details	PMID:32894755 (Click to Pubmed) ； IF: ； Citation:
Confidence