The detail information of "Interleukin-1 beta (IL-1β)"

BIOMARKER INFORMATION
Biomarker
Interleukin-1 beta (IL-1β)
Category
Molecular Changes
Affected targets
Vascular Aging
Hallmarks
Cellular Senescence
Molecular
DNA
Description
IL-1beta, a senescence-associated secretory phenotype (SASP) gene itself and a biomarker for atherosclerosis, induces cellular senescence also by upregulating CUX1 and/or downregulating SATB2 in human ECs.
EXPERIMENT INFORMATION
Region
worldwide
Race
multiple racial
Samples
/
Age
/
Gender
/
Application
Functional
Conclusion
Therefore, together, cux1 and satb2 fine-tune the expression of P16(ink4a)via their competitive, but also coordinated binding to the atherosclerosis-associated fsnp rs1537371, which precisely and tightly regulates cellular senescence in human ecs.
Reference
Gang Li, Aging Cell, 2023
Details
PMID:36633253 (Click to Pubmed) ； IF: ； Citation:
Confidence

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