Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	GrimAge
Category	Molecular Changes
Affected targets	Brain Aging
Hallmarks	Epigenetic Alterations
Molecular	DNA
Description	Epigenome-wide DNA methylation (DNAm) levels that index biological aging and earlier age of mortality were quantified by a blood-based biomarker called GrimAge.
EXPERIMENT INFORMATION
Region	USA
Race	multiple racial
Samples	3281
Age	69.4
Gender	758/981
Application	Predictive
Conclusion	The adhd-pgs was significantly and directly associated with grimage when adjusting for covariates. in single mediation models, the effect of the adhd-pgs on grimage was partially mediated via smoking, depressive symptoms, and education. in multi-mediation models, the effect of the adhd-pgs on grimage was mediated first through education, then smoking, depressive symptoms, bmi, and income.
Reference	Eileen M Crimmins, Clin Epigenentics, 2023
Details	PMID:37101297 (Click to Pubmed) ； IF: ； Citation:
Confidence