The detail information of "Autophagy/Mitophagy-Lysosomal System"

BIOMARKER INFORMATION
Biomarker
Autophagy/Mitophagy-Lysosomal System
Category
Molecular Changes
Affected targets
Skeletal Muscle Aging
Hallmarks
Disabled Macroautophagy
Molecular
Protein
Description
The autophagy–lysosome system is a pivotal component of MQC. Through this system, proteins and organelles are tagged for disposal, engulfed into an autophagosome, and ultimately delivered to the lysosome for degradation
EXPERIMENT INFORMATION
Region
worldwide
Race
multiple racial
Samples
23
Age
77.9±6.3/24.3±4.3
Gender
45637
Application
Functional
Conclusion
An altered expression of markers of the autophagy/mitophagy-lysosomal system is related to deterioration of lower extremity tissue composition and muscle dysfunction. additional studies are needed to clarify the role of defective mqc in human muscle aging and identify novel biological targets for drug development.
Reference
David A Hood, Cells, 2023
Details
PMID:36611976 (Click to Pubmed) ； IF: ； Citation:
Confidence

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