Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	DNA Methylation Age (Epigenetic Clocks)
Category	Molecular Changes
Affected targets	Instestinal Aging
Hallmarks	Epigenetic Alterations
Molecular	DNA
Description	Epigenetic clocks based on DNA methylation (DNAm) are a useful measure of the biological aging process with the potential to serve as a biomarker of an individual's susceptibility to age-related diseases such as CRC.
EXPERIMENT INFORMATION
Region	worldwide
Race	multiple racial
Samples	334
Age	19–81(58)/31–85(63)/28–79(57)
Gender	178/156
Application	Functional
Conclusion	Individuals with a high risk for crc have epigenetic age deceleration in their normal colons measured by the phenoage clock, which may reflect a dysfunctional epigenetic aging process.
Reference	William M Grady, Clin Epigenetics, 2020
Details	PMID:31900199 (Click to Pubmed) ； IF: ； Citation:
Confidence