Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Human Epigenetic Clock
Category	Molecular Changes
Affected targets	Instestinal Aging
Hallmarks	Epigenetic Alterations
Molecular	DNA
Description	here are many hallmarks of aging, including cellular senescence, telomere shortening, DNA damage, and gene expression and epigenetic changes. 20At the epigenetic level, genome-wide DNA methylation (DNAm) changes are pervasive during aging, with increased variability in methylation observed over time—a process known as epigeneticdrift.
EXPERIMENT INFORMATION
Region	California
Race	multiple racial
Samples	36
Age	/
Gender	/
Application	Functional
Conclusion	Our data validate the use of organoids as a model for studying human intestinal aging and introduce methods that can be used when modeling aging or age-onset diseases in vitro.
Reference	D Leanne Jones, Cell Mol Gastroenterol Hepatol, 2020
Details	PMID:31805439 (Click to Pubmed) ； IF: ； Citation:
Confidence