The detail information of "Urinary Extracellular Vesicles (EVs) Levels"

BIOMARKER INFORMATION
Biomarker
Urinary Extracellular Vesicles (EVs) Levels
Category
Molecular Changes
Affected targets
Kidney Aging
Hallmarks
Altered Intercellular Communication
Molecular
Protein
Description
Cells in distress release extracellular vesicles (EVs), and their numbers in urine may reflect renal injury.
EXPERIMENT INFORMATION
Region
USA(Rochester MN)
Race
multiple racial
Samples
14
Age
72.3(64–79)
Gender
45451
Application
Functional
Conclusion
Conclusions levels of p16+evs are elevated in urine of hypertensive patients and may reflect increased proximal tubular cellular senescence. in eh, evs originate also from distal tubules and in renovascular hypertension from henle's loop. hence, urinary evs levels may be useful to identify intrarenal sites of cellular senescence.
Reference
Lilach O Lerman, J Am Heart Assoc, 2019
Details
PMID:31433703 (Click to Pubmed) ； IF: ； Citation:
Confidence

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