The detail information of "Tumor Necrosis Factor Alpha (TNF-α)"

BIOMARKER INFORMATION
Biomarker
Tumor Necrosis Factor Alpha (TNF-α)
Category
Cellular Alterations
Affected targets
Skeletal Muscle Aging
Hallmarks
Loss of Proteostasis
Molecular
Other
Description
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker. Anti-TNF-α, a natural consequent autoantibody to TNF-α, is an indicator of relatively prolonged TNF-α exposure, has more stable concentrations than TNF-α and should be a better alteRNAtive as a biomarker of sarcopenia.
EXPERIMENT INFORMATION
Region
Taiwan(China)
Race
multiple racial
Samples
484
Age
69.3
Gender
241/243
Application
Functional
Conclusion
Anti-tnf-α may be a more appropriate biomarker than tnf-α for sarcopenia, but further investigations are needed to confirm its roles in sarcopenia diagnosis and treatment response evaluation.
Reference
Liang-Kung Chen, Experimental gerontology, 2022
Details
PMID:36509297 (Click to Pubmed) ； IF: ； Citation:
Confidence

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