Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	MTS1 (Multiple Tumor Suppressor 1)
Category	Molecular Changes
Affected targets	Instestinal Aging
Hallmarks	Cellular Senescence
Molecular	DNA
Description	We analyzed the impact of P16(ink4a)expression, a hallmark of cellular senescence, in intestinal biopsies of patients with lower GI GVHD symptoms and NFKB1 gene polymorphisms (rs3774937 C/T and rs3774959 A/G) on HSCT outcome.
EXPERIMENT INFORMATION
Region	Czech Republic
Race	multiple racial
Samples	52
Age	/
Gender	26/26
Application	Functional
Conclusion	Our results address possible new mechanisms that may lead to better understanding of hsct-related immune complications. cellular senescence may bring novel approaches in gvhd diagnostics and therapy.
Reference	Tomas Papajik, Transplant immunology, 2022
Details	PMID:36470572 (Click to Pubmed) ； IF: ； Citation:
Confidence