The detail information of "Senolytic Agents"

BIOMARKER INFORMATION
Biomarker
Senolytic Agents
Category
Cellular Alterations
Affected targets
Vascular Aging
Hallmarks
Cellular Senescence
Molecular
Other
Description
Here we report a molecular design to tackle this challenge through multidimensional, hierarchical recognition of three hallmarks commonly shared among senescence, namely, aptamer-mediated recognition of a membrane marker for active cell targeting, a self-immolative linker responsive to lysosomal enzymes for switchable drug release, and a compound against antiapoptotic signaling for clearance.
EXPERIMENT INFORMATION
Region
China
Race
multiple racial
Samples
/
Age
/
Gender
/
Application
Anti-Aging
Conclusion
Its potential for in vivo treatment of vascular diseases is successfully illustrated in a model of atherosclerosis, with effective suppression of the plaque progression yet negligible side effects.
Reference
Yanlan Liu, Angewandte Chemie (International ed. in English), 2022
Details
PMID:36445796 (Click to Pubmed) ； IF: ； Citation:
Confidence

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