The detail information of "Stromal Interaction Molecule 1 (STIM1) and Orai Calcium Release-Activated Calcium Modulator (ORAI)"

BIOMARKER INFORMATION
Biomarker
Stromal Interaction Molecule 1 (STIM1) and Orai Calcium Release-Activated Calcium Modulator (ORAI)
Category
Molecular Changes
Affected targets
Vascular Aging
Hallmarks
Cellular Senescence
Molecular
Protein
Description
Different systems control the cell's capacity to manage the calcium level, where the store-operated calcium entry (SOCE) through stromal interaction molecule (STIM)-gated Orai channels plays a key role
EXPERIMENT INFORMATION
Region
Spain
Race
white
Samples
30/15
Age
43/73.7
Gender
31/14
Application
Functional
Conclusion
Aging is associated with an increased expression of the stim/orai system in human vessels with functional relevance only in the microvascular territory, suggesting its role in aging-related microvascular dysfunction.
Reference
Javier Angulo, Cells, 2022
Details
PMID:36429103 (Click to Pubmed) ； IF: ； Citation:
Confidence

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