Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Human Amniotic Membrane Extract (hAME)
Category	Cellular Alterations
Affected targets	Skin Aging
Hallmarks	Mitochondrial Dysfunction
Molecular	Other
Description	Human amniotic membrane (hAM), which is the innermost extra-embryonic tissue, is now considered as a beneficial natural biomaterial. AM is immune-privileged and contains a number of growth factors and cytokines such as hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and interleukin-1 (IL-1), which are necessary for the repair process.
EXPERIMENT INFORMATION
Region	UK
Race	multiple racial
Samples	/
Age	/
Gender	/
Application	Anti-Aging
Conclusion	Our findings showed that ame has beneficial effects on oxidative stress-induced ageing fibroblasts. ame increased cellular viability and proliferation. it also reduced cellular senescence and demonstrated an an- tioxidative effect. according to the results, this study demonstrates for the first time that ame could be con- sidered as a beneficial candidate for a novel natural- based antiageing cosmeceutical ingredient to use in dermatologic formulations.
Reference	Masoumeh Nouri, Int J Cosmet Sci., 2023
Details	PMID:36129819 (Click to Pubmed) ； IF: ； Citation:
Confidence