The detail information of "Senescence-Associated Secretory Phenotype (SASP)"

BIOMARKER INFORMATION
Biomarker
Senescence-Associated Secretory Phenotype (SASP)
Category
Cellular Alterations
Affected targets
Liver Aging
Hallmarks
Cellular Senescence
Molecular
Protein
Description
The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development.
EXPERIMENT INFORMATION
Region
Germany
Race
/
Samples
/
Age
/
Gender
/
Application
Anti-Aging
Conclusion
Arsenite exposure induces premature senescence in human hepatic stellate cells, followed by sasp induction, and the effects of arsenite exposure persist even after cessation of arsenite exposure (fig. 10). clearance of senescent cells is a new therapeutic strategy for age-related diseases (baker et al., 2011; kirkland and tchkonia, 2020). the removal of senescent cells has been shown to be effective for preventing the development of hcc (wang et al., 2019; wakita et al., 2020). therefore, premature senescence induced by arsenite exposure could be a potential therapeutic target for arsenite exposure-induced carcinogenesis.
Reference
Kazuyuki Okamura, Toxicol Appl Pharmacol., 2022
Details
PMID:36089002 (Click to Pubmed) ； IF: ； Citation:
Confidence

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