The detail information of "Cyclin-dependent kinase inhibitor 1A (CDKN1A)"

BIOMARKER INFORMATION
Biomarker
Cyclin-dependent kinase inhibitor 1A (CDKN1A)
Category
Molecular Changes
Affected targets
Liver Aging
Hallmarks
Cellular Senescence
Molecular
DNA
Description
The protein p21 is encoded by CDKN1A. Studies in diverse conditions showed that CDKN1A variants are associated with the rate of disease progression.
EXPERIMENT INFORMATION
Region
UK/Finland
Race
multiple racial
Samples
446
Age
52.0(UK)/46.0(Finland)
Gender
250/196
Application
Functional
Conclusion
Cdkn1a variant rs762623( involved in cellular senescence) is associated with the development but not the propagation of progressive liver disease in nafld.
Reference
Graeme Alexander, Cell Cycle., 2014
Details
PMID:24626178 (Click to Pubmed) ； IF: ； Citation:
Confidence

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