Aging-BC_Biomarker_Information

The detail information of "Handgrip Strength (HGS)"

BIOMARKER INFORMATION
Biomarker	Handgrip Strength (HGS)
Category	Physiological Characteristics
Affected targets	Skeletal Muscle Aging
Hallmarks	Loss of Proteostasis
Molecular	Other
Description	Grip strength (GS), in particular, has been used as a surrogate of overall muscle strength as it correlates with strength not only in the upper extremities but also with other muscle groups. Declines in GS have been associated in many studies with functional disabilities, morbidity, or mortality, and GS has been deemed an important biomarker.
EXPERIMENT INFORMATION
Region	Europe
Race	multiple racial
Samples	48070
Age	60(50-80)
Gender	24035/24035
Application	Functional
Conclusion	We observed that the rate of decline in grip strength with age is nonlinear and accelerates at older ages. for females the rate of decline is constant after age 50 possibly due to reaching menopausal status before it accelerates at older ages. we provide reference values of grip strength for males and females engaged in vigorous physical activities in different regions. this may be helpful to health care providers and exercise physiologists as it adds information to existing reference values in general populations irrespective of physical activity. a clear understanding of the rate of decline in grip strength with increasing age and determinants for grip strength as a surrogate for muscle strength can provide insights into strength across the lifespan. a relevant implication is to encourage vigorous physical activities at all ages and possibly increasing the volume with increasing age [18], and to target weight management to slow the decline in grip strength and thus improve quality of life.
Reference	Marianne Huebner, Int J Environ Res Public Health., 2022
Details	PMID:36078725 (Click to Pubmed) ； IF: ； Citation:
Confidence

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