Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	p21 (CDKN1A)
Category	Cellular Alterations
Affected targets	Liver Aging
Hallmarks	Cellular Senescence
Molecular	Protein
Description	Irreversible cell cycle arrest that limits the proliferative potential of cells is a feature of cellular senescence and is mediated by p21, a universal cell cycle inhibitor [10]. p21 also contributes to the stability of cell cycle arrest long after the induction of senescence [10].
EXPERIMENT INFORMATION
Region	UK
Race	/
Samples	119
Age	26-80
Gender	73/46
Application	Predictive
Conclusion	The findings are consistent with impaired cell cycle progression beyond the g1/s phase in ald. the striking independent associations between increased hepatocyte p21 expression and both fibrosis stage and an adverse liver-related outcome in both cohorts suggests hepatocyte senescence plays an important role in ald. measuring hepatocyte p21 expression is simple and cheap and in this series was a useful measure of long-term prognosis in ald.
Reference	Graeme J. M. Alexander, PLoS One, 2013
Details	PMID:24086266 (Click to Pubmed) ； IF: ； Citation:
Confidence