Aging-BC_Biomarker

BIOMARKER INFORMATION
Biomarker	Histone H2A.J
Category	Cellular Alterations
Affected targets	Skin Aging
Hallmarks	Cellular Senescence
Molecular	Other
Description	Previous studies have shown that histone variant H2A.J accumulates in human fibroblasts during replicative and radiation-induced senescence and modulates the secretion of inflammatory cytokines. Our previous research shows that H2A.J is a sensitive marker of senescent keratinocytes in the human epidermis in the context of skin aging.
EXPERIMENT INFORMATION
Region	Germany
Race	multiple racial
Samples	12
Age	1–9
Gender	36861
Application	Functional
Conclusion	Cultured foreskin characterized by highly keratinized epithelium and specific immunological features is not an appropriate model for studying h2a.j-associated tissue reactions during radiation-induced dermatitis.
Reference	Claudia E Rübe, Int J Mol Sci., 2022
Details	PMID:36077226 (Click to Pubmed) ； IF: ； Citation:
Confidence